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  1. Consolidation of the HERA-WGS-infrastructure and capacity building at NIPH to enhance microbial surveillance and preparedness

    The general objective of this project is to further strengthen and expand our microbial WGS analysis. We will do this by automation of our laboratory workflow, including digitalisation of instrument data, expanding the current WGS activity to other pathogens, and develop downstream visualisation and reporting platforms. This will allow us to more rapidly and efficiently respond to the Covid-19 pandemic, as well as enhance our preparedness for future pathogens and other cross-border threats.

    Prosjekt

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  2. Protein glycans as vaccine antigens against pathogenic Neisseria gonorrhoeae

    Neisseria gonorrhoeae, the causative agent of the sexually transmitted infection gonorrhea, represents an emerging global health problem with an estimated 87 million new cases annually. Gonococcal infection has especially severe effects on women's reproductive health. There is an urgent need for the development of a gonorrhea vaccine as currently no vaccines are available and antimicrobial resistance has raised to the specter of untreatable infections.

    Prosjekt

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  3. Protein glykosylering, glykan diversitet og immun respons i Neisseria meningitidis

    Bacterial meningitis is a serious global health problem and one of the major causative organisms is Neisseria meningitidis, which is also a common commensal in the upper respiratory tract of healthy humans and the only agent able to cause epidemics of meningitis. In bacteria, numerous loci involved in biosynthesis of surface exposed antigenic structures, such as outer lipopolysaccharides, lipoproteins, pili, flagella and other secreted proteins that are involved in the interaction between bacteria and host, are frequently subjected to homologous recombination and phase variation. These mechanisms are well described in Neisseria, and phase variation provides the ability to change these structures reversibly in response to the environment.

    Prosjekt

    Publisert Oppdatert