Birgit Øvstebø Engesæter
seniorrådgiver, PhD

Kontakt
Mob: 229 28 704
Send e-post {model.translations.sendEmailTo} Birgit.Ovstebo.Engesaeter@fhi.no
Avdeling
Fagområder
Birgit Engesæter sine pågående prosjekter inkluderer monitorering av primær HPV-screening i Norge. Primær HPV-screening ble initiert som et pilotprosjekt i tre prøvefylker i 2015. Fra perioden januar 2019 til mars 2022 var det en nasjonal implementering av HPV-screening til kvinner i alderen 34-69 år, og fra 2023 ble kvinner i alderen 25-33 år også tilbudt HPV-screening.
Innføring av HPV-screening gir et kontinuerlig behov for å optimalisere flytskjemaet som beskriver oppfølging av kvinner som deltar i Livmorhalsprogrammet. Dette inkluderer vurdering av anbefalinger basert på diagnosekombinasjoner, aldersgrupper og tidligere screeninghistorikk, samt eventuelle inkluderinger av nye biomarkører for bedre risikostratifisering av kvinnene. Engesæter har en sentral rolle i dette arbeidet.
Hvert år sammenstilles de viktigste resultatene fra Livmorhalsprogrammet i en årsrapport. I tillegg initieres det fortløpende spesifikke kvalitetssikrings- og forskningsprosjekt. Engesæter har ansvar for uttrekk av data til årsrapport og de spesifikke prosjekter, og bidrar til å sikre og opprettholde høy kvalitet i Livmorhalsprogrammet.
Engesæter har også en viktig rolle i et forskningsprosjekt som har som mål å identifisere nye biomarkører for bedre stratifisering av kvinner med persisterende HPV-infeksjon. Dette prosjektet er finansiert blant annet av Kreftforeningen, Helse SørØst og HelseMidt.
Prosjekter og publikasjoner
- Ingrid Baasland, Tone Bjørge, Birgit Øvstebø Engesæter, Ameli Ellen Claesdotter Tropé, Signe Opdahl, (2025). Cervical intraepithelial neoplasia grade 1 and long-term risk of progression and treatment. PLOS ONE doi: 10.1371/journal.pone.0320739
- Tone Bjørge, Nathalie Charlotte Støer, Sara Kristine Kildal Hverven, Mari Kiens Nygård, Ameli Ellen Claesdotter Tropé, Birgit Øvstebø Engesæter, (2025). Risk of high-grade cervical lesions in the second round of primary human papillomavirus testing in CervicalScreen Norway: A population-based cohort study. International Journal of Cancer doi: 10.1002/ijc.35359
- Allison Portnoy, Kine Pedersen, Stephen Sy, Ameli Ellen Claesdotter Tropé, Birgit Øvstebø Engesæter, Jane J. Kim, Emily Annika Burger, (2023). Cost-effectiveness of primary human papillomavirus triage approaches among vaccinated women in Norway: A model-based analysis. International Journal of Cancer doi: 10.1002/ijc.34804
- Tone Bjørge, Birgit Øvstebø Engesæter, Gry Baadstrand Skare, Ameli Trope, (2022). CervicalScreen Norway – A screening programme in transition. Norsk Epidemiologi s. 55-60. doi: 10.5324/nje.v30i1-2.4978
- Mari Nygård, Birgit Øvstebø Engesæter, Philip E. Castle, Jannicke Berland, Maj Liv Eide, Ole-Erik Iversen, Christine M Jonassen, Irene Kraus Christiansen, Olav Karsten Vintermyr, Ameli Trope, (2022). Randomized implementation of a primary human papillomavirus testing-based cervical cancer screening protocol for women 34 to 69 years in Norway. Cancer Epidemiology, Biomarkers and Prevention s. 1812-1822. doi: 10.1158/1055-9965.EPI-22-0340
- Irene Tveiterås Øvestad, Birgit Øvstebø Engesæter, Mari Kyllesø Halle, Saleha Akbari, Beatrix Bicskei, Morten Lapin, Marie Austdal, Emiel Janssen, Camilla Krakstad, Melinda Lillesand, Marit Nordhus, Ane Cecilie Dæhli Munk, Einar Gudlaugsson, (2021). High-Grade Cervical Intraepithelial Neoplasia (CIN) Associates with Increased Proliferation and Attenuated Immune Signaling. International Journal of Molecular Sciences doi: 10.3390/ijms23010373
- Mari Kyllesø Halle, Ane Cecilie Dæhli Munk, Birgit Øvstebø Engesæter, Saleha Akbari, Astri Frafjord, Erling Andre Høivik, David Erik Forsse, Kristine Eldevik Fasmer, Kathrine Woie, Ingfrid S. Haldorsen, Bjørn Bertelsen, Emiel Janssen, Einar Gudlaugsson, Camilla Krakstad, Irene Tveiterås Øvestad, (2021). A gene signature identifying CIN3 regression and cervical cancer survival. Cancers s. 1-18. doi: 10.3390/cancers13225737
- Dana Kristjansson, Birgit Øvstebø Engesæter, Gry Baadstrand Skare, Philip E. Castle, Tone Bjørge, Ameli Trope, Mari Nygård, (2020). Real-world data on cervical cancer risk stratification by cytology and HPV genotype to inform the management of HPV-positive women in routine cervical screening. British Journal of Cancer s. 1715-1723. doi: 10.1038/s41416-020-0790-1
- Ondřej Májek, Ahti Anttila, Marc Arbyn, Evert-Ben van Veen, Birgit Øvstebø Engesæter, Stefan Lönnberg, (2019). The legal framework for European cervical cancer screening programmes. European Journal of Public Health s. 345-350. doi: 10.1093/eurpub/cky200
- Trude Andreassen, Bo Terning Hansen, Birgit Øvstebø Engesæter, Dana Hashim, Nathalie Charlotte Støer, Ameli Trope, Kåre Moen, Giske Ursin, Elisabete Weiderpass, (2019). Psychological effect of cervical cancer screening when changing primary screening method from cytology to high-risk human papilloma virus testing. International Journal of Cancer s. 29-39. doi: 10.1002/ijc.32067
- Marius Strømbo Eng, Jagdip Kaur, Lina Prasmickaite, Birgit Øvstebø Engesæter, Anette Weyergang, Ellen Skarpen, Kristian Berg, Michael G. Rosenblum, Gunhild Mari Mælandsmo, Anders Høgset, Soldano Ferrone, Pål Kristian Selbo, (2018). Enhanced targeting of triple-negative breast carcinoma and malignant melanoma by photochemical internalization of CSPG4-targeting immunotoxins. Photochemical and Photobiological Sciences s. 539-551. doi: 10.1039/c7pp00358g
- Karianne Giller Fleten, Vivi Ann Flørenes, Lina Prasmickaite, Oliver Hill, Jaromir Sykora, Gunhild Mælandsmo, Birgit Øvstebø Engesæter, (2016). hvTRA, a novel TRAIL receptor agonist, induces apoptosis and sustained growth retardation in melanoma. Cell death discovery doi: 10.1038/cddiscovery.2016.81
- Stefan Lönnberg, Trude Andreassen, Birgit Øvstebø Engesæter, Rune Lilleng, Cecilia Kleven, Annelie Skare, Karin Johansson, Christina Stangeland Fredheim, Ameli Trope, (2016). Impact of scheduled appointments on cervical screening participation in Norway: a randomised intervention. BMJ Open s. 1-7. doi: 10.1136/bmjopen-2016-013728
- Birgit Øvstebø Engesæter, Bianca Van Diermen, Mona Lindsethmo Hansen, Pia Moltu, Kjersti Mangseth, Siri Borchgrevink-Persen, Olav Karsten Vintermyr, Stefan Lönnberg, Mari Nygård, Emiel Janssen, Philip E. Castle, Hanne Irene Kraus, (2016). Quality assurance of human papillomavirus (HPV) testing in the implementation of HPV primary screening in Norway: An inter-laboratory reproducibility study. BMC Infectious Diseases doi: 10.1186/s12879-016-2028-7
- Kotryna Vasiliauskaite, Karianne Giller Fleten, Anna Barkovskaya, Vigdis Nygaard, Mads Haugland Haugen, Birgit Øvstebø Engesæter, Gunhild Mælandsmo, Lina Prasmickaite, (2016). Fibroblast-induced switching to the mesenchymal-like phenotype and PI3K/mTOR signaling protects melanoma cells from BRAF inhibitors. OncoTarget s. 19997-20015. doi: 10.18632/oncotarget.7671
- Gry Irene Magnussen, Elisabeth Emilsen, Karianne Giller Fleten, Birgit Øvstebø Engesæter, Viola Nahse-Kumpf, Roar Fjær, Ana Slipicevic, Vivi Ann Flørenes, (2015). Combined inhibition of the cell cycle related proteins Wee1 and Chk1/2 induces synergistic anti-cancer effect in melanoma. BMC Cancer doi: 10.1186/s12885-015-1474-8
- Ana Slipicevic, Geir Frode Øy, Anne Katrine Ree Rosnes, Øystein Stakkestad, Elisabeth Emilsen, Birgit Øvstebø Engesæter, Gunhild Mælandsmo, Vivi Ann Flørenes, (2013). Low-dose anisomycin sensitizes melanoma cells to TRAIL induced apoptosis. Cancer Biology & Therapy s. 146-154. doi: 10.4161/cbt.22953
- Birgit Øvstebø Engesæter, Olav Engebråten, Vivi Ann Flørenes, Gunhild Mælandsmo, (2012). Dacarbazine and the Agonistic TRAIL Receptor-2 Antibody Lexatumumab Induce Synergistic Anticancer Effects in Melanoma. PLOS ONE doi: 10.1371/journal.pone.0045492
- Gry Irene Magnussen, Anne Katrine Ree Rosnes, Susan Shahzidi, Phuc Hiep Dong, Elisabeth Emilsen, Birgit Øvstebø Engesæter, Vivi Ann Flørenes, (2012). Synthetic retinoid CD437 induces apoptosis and acts synergistically with TRAIL receptor-2 agonist in malignant melanoma. Biochemical and Biophysical Research Communications - BBRC s. 516-522. doi: 10.1016/j.bbrc.2012.03.023
- Sigurd Bøe, Lina Prasmickaite, Birgit Øvstebø Engesæter, Eivind Hovig, (2011). Light-directed delivery of nucleic acids. Methods in molecular biology s. 107-121. doi: 10.1007/978-1-61779-188-8_7
- Birgit Øvstebø Engesæter, Menaka Sathermugathevan, Tina Hellesnes, Olav Engebråten, Ruth Holm, Vivi Ann Flørenes, Gunhild Mælandsmo, (2011). Targeting inhibitor of apoptosis proteins in combination with dacarbazine or TRAIL in melanoma cells. Cancer Biology & Therapy s. 47-58. doi: 10.4161/cbt.12.1.15714
- Lina Prasmickaite, Birgit Øvstebø Engesæter, Nirma Skrbo-Larssen, Tina Hellenes, Alexandr Kristian, Nina Kristine Oliver, Zhenhe Suo, Gunhild Mælandsmo, (2010). Aldehyde Dehydrogenase (ALDH) Activity Does Not Select for Cells with Enhanced Aggressive Properties in Malignant Melanoma. PLOS ONE doi: 10.1371/journal.pone.0010731
- Birgit Øvstebø Engesæter, Anette Bonsted, Trine Lillehammer, Olav Engebråten, Kristian Berg, Gunhild M Mælandsmo, (2006). Photochemically mediated delivery of AdhCMV-TRAIL augments the TRAIL-induced apoptosis in colorectal cancer cell lines. Cancer Biology & Therapy s. 1511-1520.
- Andreas Dietze, Pål Kristian Selbo, Lina Prasmickaite, Anette Weyergang, Anette Bonsted, Birgit Engesæter, Anders Høgset, Kristian Berg, (2006). Photochemical Internalization (PCI): A New Modality for Light Activation of Endocytosed Therapeuticals. Journal of Environmental Pathology And Toxicology s. 521-536. doi: 10.1615/JEnvironPatholToxicolOncol.v25.i1-2.330
- Kristian Berg, Pål Kristian Selbo, Anette Weyergang, Andreas Dietze, Lina Prasmickaite, Anette Bonsted, Birgit Øvstebø Engesæter, Even Angell-Petersen, Trond Warloe, N. Frandsen, Anders Høgset, (2005). Porphyrin-related photosensitizers for cancer imaging and therapeutic applications. Journal of Microscopy s. 133-147. doi: 10.1111/j.1365-2818.2005.01471.x
- Anders Høgset, Lina Prasmickaite, Pål Kristian Selbo, Marit Hellum, Birgit Øvstebø Engesæter, Anette Bonsted, Kristian Berg, (2004). Photochemical internalisation in drug and gene delivery. Advanced Drug Delivery Reviews s. 95-115. doi: 10.1016/j.addr.2003.08.016
- Kristian Berg, Lina Prasmickaite, Pål Kristian Selbo, Marit Hellum, Anette Bonsted, Birgit Øvstebø Engesæter, Anette Weyergang, Anders Høgset, (2003). Photochemical Internalisation - A novel technology for light-directed delivery of macromolecule therapy. s. 168-172.
- Lina Prasmickaite, Anders Høgset, Pål Kristian Selbo, Birgit Øvstebø Engesæter, Marit Hellum, Kristian Berg, (2002). Photochemical disruption of endocytic vesicles before delivery of drugs: a new strategy for cancer therapy. British Journal of Cancer s. 652-657. doi: 10.1038/sj.bjc.6600138
- Ingrid Baasland, Signe Opdahl, Tone Bjørge, Ameli Trope, Birgit Øvstebø Engesæter, Gry Baadstrand Skare, (2021). Long-term risk of progression following CIN1.
- Ameli Trope, Mari Nygård, Birgit Øvstebø Engesæter, Trude Andreassen, Stefan Lönnberg, Giske Ursin, (2017). Trygg implementering av HPV-testing i Livmorhalsprogrammet :. Tidsskrift for Den norske legeforening (Tidsskriftet) s. 1274-1275. doi: 10.4045/tidsskr.17.0306
- Birgit Øvstebø Engesæter, Bianca Van Diermen, Mona Hansen, Pia Moltu, Siri Borchgrevink-Persen, Olav Karsten Vintermyr, Stefan Lönnberg, Mari Nygård, Emiel Janssen, (2016). Inter-laboratory reproducibility of the cobas 4800 HPV test in cervical cancer screening in Norway.
- Ana Slipicevic, Geir Frode Øy, Birgit Øvstebø Engesæter, Gunhild Mælandsmo, Vivi Ann Flørenes, (2010). Sensitization of melanoma cells to TRAIL-R2 agonist antibody by low-dose anisomycin. European Journal of Cancer s. 69-69.