Access to biological material from MoBa
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Here is information on how to apply for access to biological material from MoBa and what requirements are set, as well as information on the extraction process.
Application
To gain access to biological material from MoBa, the MoBa biological material form must be completed and attached to the application.
Requirements for applications for biological material
1. Applicants must become well acquainted with the biological material included in MoBa before submitting the application. Information on which biological materials are available in MoBa can be found on our website, as well as in the protocol and in the reference articles.
- Sample overview of the MoBa biobank (website)
- Protocols
- Publication guidelines where the reference articles are listed
2. The amount of biological material in the biobank is limited, thus high requirements for scientific quality are set for projects planning to use material from MoBa.
- The research question(s) must be possible to be studied using biological material. New materials will not be provided if there already is data (including analysis results) that can be used to study the research question(s).
- The MoBa material must be suitable for the chosen method of analysis.
- For some analyses MoBa will set requirements, for example for the type of chip used in methylation analyses. This is so that results from different projects can be used together/compiled.
- The method of analysis applied must use the lowest possible sample volume, and should measure several components per sample to maximise the utilisation of the biological material.
- Only the needed amount of material will be provided.
- A calculation of statistical power in the analysis must be performed by the project. This must be made available for MoBa upon request.
- Control groups are chosen randomly unless there is good reason why random controls are not sufficient for the planned analysis. MoBa can assist in the selection of random control groups.
3. The results from the analyses of the biological material must be returned to MoBa and can then be used by other research projects.
Requirements for the laboratory
Currently, MoBa does not allow biological materials to be sent to countries outside the EU/EEA. Laboratories that are subject to European legislation (GRPR) must therefore be used. The applicant / PI must enter into necessary agreements with the laboratory where the samples are to be analysed.
The laboratory must undertake to and perform the work in accordance with the terms set out in the MTA entered into between MoBa and the project. The laboratory must guarantee to comply with and perform any and all analyses in accordance with the following conditions and terms.
Analysis report
The laboratory and the project shall provide MoBa (biobank-bioretrieval@fhi.no) with a completed analysis report when analysis has been completed. Templates (se below) for this will be sent to laboratory and project when samples are shipped.
- All sections of the analysis report relating to sample processing and handling, as well as analytical methods and hardware, should be completed with as much detail as possible.
- The laboratory is required to list all samples (using the RetrivelDetail-ID received with the samples) which failed to produce analytical data, along with an explanation that describes the origin or cause of this failure.
- The laboratory will inform MoBa of any known batch effects or variations in the dataset (intra and inter variation), if applicable.
Templates of the analysis report
- DNA/RNA - analysis report to be completed by researcher/principal investigator (download Word document)
- DNA/RNA - analysis report to be completed by the laboratory (download Word dokument)
- Plasma/urine/blood - analysis report to be completed by researcher/principal investigator (download Word document)
- Plasma/urine/blood - analysis report to be completed by laboratory (download Word document)
Delivery of biological material and price for access
The process for extracting biological material consists of several parts:
- MoBa biological material form must be completed and attached to the application. The form includes information on criteria for the study population.
- A list of individuals(study population) that will be included in the project is made. This will either be done by the project, or by the data unit, MorBarnData@fhi.no, after criteria made by the project.
- A sampling manager in the biobank will prepare a list of samples based on the list of individuals. An estimate for the delivery of the materials will be given when the sample list has been determined.
- The biobank collects the sample materials, prepares it for delivery, and sends it to the laboratory for analysis, in accordance with the agreement with the project.
During periods of high demand for biological material, increased processing time and delivery time will have to be expected. The project will in this case be notified.
Significant changes after the application has been approved and an agreement has been signed by the applicant will result in a renewed processing of the application. Delivery will then be delayed.
More information about the delivery of biological material and prices for the material can be found here: Retrieval of biological material
After analysis of biological samples
Once the samples have been analysed, the results and the completed analysis report must be returned to MoBa. Thereafter, the questionnaire data and linkage keys will be handed out in dialogue with the data manager. More information about returning and deleting data can be found here: The return of results, data and generated variables from research projects to MoBa
Contact information
Case manager in MoBa (MoBaadm@fhi.no):
- General questions about the use of MoBa for research
- Wants to discuss the possibility of a research project
- Commercial actors
Data manager in MoBa (MorBarnData@fhi.no):
- Questions related to what data and variables are available in MoBa
- Questions about linkage to other data sources
Biobank (Biobank-BioRetrieval@fhi.no):
- Questions about biological materials