EXPOSIM
The EU Horizon Europe project EXPOSIM studies environmental stressors as causal determinants for immune-mediated diseases to map and prioritise evidence for knowledge-based policy-making. EXPOSIM is coordinated by KU Leuven.
Om prosjektet
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Prosjektperiode: 01.01.2025 - 31.12.2029 (Aktivt)
- Koordinerende institutt: KU Leuven
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Prosjektmedarbeider:
- Hubert Dirven, Berit Brunstad Granum, Johanna Eva Bodin, Unni Cecilie Nygaard
Sammendrag
Child cohorts such as PreventADALL (Norway), ENVIRONAGE (Belgium), and FEPOS (Denmark) are being used to investigate environmental influences during early life and their impact on immune health. Occupational cohorts are also studied in the EXPOSIM project.
NIPH will study the effects of environmental factors on immune health such as allergy and asthma development in children, using blood samples from the Norwegian PreventADALL cohort. External exposome components like air pollution, green spaces and noise exposure during pregnancy will be modelled, and associations with immune health until 3 years of age will be explored. We will integrate a novel set of outcomes of respiratory and immune development, including foetal thoracic circumference, lung function, biomarkers of asthma, allergic diseases such as atopic dermatitis and food allergy, as well as immunosuppression assessed through vaccination responses to childhood vaccines.
To strengthen causality between observed exposure-health associations, high-dimensional immune cell profiling will be performed by in-depth single-cell (mass cytometry/CyTOF) and multiplex cytokine analyses.
More information and resources can be found on the EXPOSIM website.