2022

Characterization of the genetic architecture of infant and early childhood BMI

Here we present the summary data of the discovery phase for our genome-wide analyses of body mass index (BMI) in the Norwegian Mother, Father and Child Cohort Study. 

The results are published in the article: <link to paper will be available when published>

Results are from the genome-wide association analyses at each of the twelve distinct time points; birth, 6 weeks, 3 months, 6 months, 8 months, 1 year, 1.5 years, 2 years, 3 years, 5 years, 7 years and 8 years can be downloaded below (see paper for full details). 

All BMI measures were z-score transformed prior to analysis. The association between each genetic variant and BMI was tested using linear mixed model regression analyses with adjustment for sex, gestational age, genotyping batch and ten principal components as covariates. Summary files contain information on rsID of marker, chromosome, genomic position (NCBI build 37), effect allele, other allele, effect allele frequency, imputation quality (info-score), beta, standard error, p-value, and samples size on approximately 9.2 million markers at each time point

Summary data from the study: 

childhood_bmi_nature_metab_2022_birth.gz

childhood_bmi_nature_metab_2022_6weeks.gz

childhood_bmi_nature_metab_2022_3months.gz

childhood_bmi_nature_metab_2022_6months.gz

childhood_bmi_nature_metab_2022_8months.gz

childhood_bmi_nature_metab_2022_1year.gz

childhood_bmi_nature_metab_2022_1.5years.gz

childhood_bmi_nature_metab_2022_2years.gz

childhood_bmi_nature_metab_2022_3years.gz

childhood_bmi_nature_metab_2022_5years.gz

childhood_bmi_nature_metab_2022_7years.gz

childhood_bmi_nature_metab_2022_8years.gz

2019

Novel Tools for Early Childhood Predisposition to Obesity and Diabetes (ERC AdG - HARVEST)

Here we present the summary data of the discovery phase for our genome-wide analyses of body mass index (BMI) in the Norwegian Mother, Father and Child Cohort Study. 

The results are published in the article: Helgeland, Ø. et al. Genome-wide association study reveals dynamic role of genetic variation in infant and early childhood growth. Nat. Commun. 10, 4448 (2019).

Results are from the genome-wide association analyses at each of the twelve distinct time points; birth, 6 weeks, 3 months,  6 months, 8 months, 1 year,  1.5 years, 2 years, 3 years, 5 years, 7 years and 8 years can be downloaded below (see paper for full details). 

All BMI measures were z-score transformed prior to analysis. The association between each genetic variant and BMI was tested using linear regression with adjustment for sex, batch and ten principal components as covariates. Summary files contain information on rsID of marker, chromosome, genomic position (NCBI build 37), effect allele, other allele, effect allele frequency,  beta, standard error, p-value, and samples size on approximately 8.5 million markers at each time point.

Data files

• childhood_bmi_nat_comm_2019_birth.gz
• childhood_bmi_nat_comm_2019_6weeks.gz
• childhood_bmi_nat_comm_2019_3months.gz
• childhood_bmi_nat_comm_2019_6months.gz
• childhood_bmi_nat_comm_2019_8months.gz
• childhood_bmi_nat_comm_2019_1year.gz
• childhood_bmi_nat_comm_2019_1.5years.gz
• childhood_bmi_nat_comm_2019_2years.gz
• childhood_bmi_nat_comm_2019_3years.gz
• childhood_bmi_nat_comm_2019_5years.gz
• childhood_bmi_nat_comm_2019_7years.gz
• childhood_bmi_nat_comm_2019_8years.gz

Acknowledging the data

When using data from the downloadable meta-analyses results please acknowledge the source of the data as follows:

Results on BMI from birth to childhood have been contributed by the Centre For Diabetes Research, University of Bergen, Norway, and the Norwegian Mother, Father and Child study, and has been downloaded from: https://www.fhi.no/en/studies/moba/for-forskere-artikler/gwas-data-from-moba/

Please cite the article as follows:

Helgeland, Ø. et al. Genome-wide association study reveals dynamic role of genetic variation in infant and early childhood growth. Nat. Commun. 10, 4448 (2019).