Genetic understanding of the relationship between height and preeclampsia
Project
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The purpose is to understand the causes of preeclampsia
Summary
The purpose is to understand the causes of preeclampsia
Abstract:
The purpose is to understand the causes of preeclampsia. It has long been known that maternal height is associated with the risk of developing preeclampsia during pregnancy. To understand this further, we will see if paternal height is also associated with the mother's risk. If this is not the case, we can conclude that the effect does not go via fetal genes. To understand the effect of maternal height, we will also use results from another project where we have the genotype of 11,000 mother-father-child trios from the Norwegian Mother and Child Study (MoBa). We will calculate the so-called polygene risk score for height based on the genotypes. If this turns out to be associated with maternal risk of preeclampsia, we will have stronger evidence to say that there is a causal relationship between height and preeclampsia. This can lead us on the trail of the causes of this serious disease.
Project leader
Per Minor Magnus, Norwegian Institute of Public Health
Project participants
Per Minor Magnus, Centre for Fertility and Health, Norwegian Institute of Public Health
Astanand Jugessur, Genetics and Bioinformatics, Norwegian Institute of Public Health
Øyvind Helgeland, Genetics and Bioinformatics, Norwegian Institute of Public Health
About the project
Start
15.06.2017
End
31.12.2024
Status
Active
Approvals
Regional committees for medical and health research ethics
Project owner/ Project manager
Norwegian Institute of Public Health