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  • Genetic understanding of the relationship between height and preeclampsia

Project

Genetic understanding of the relationship between height and preeclampsia - project description

Published Updated

The purpose is to understand the causes of preeclampsia


Summary

The purpose is to understand the causes of preeclampsia

Abstract:

The purpose is to understand the causes of preeclampsia. It has long been known that maternal height is associated with the risk of developing preeclampsia during pregnancy. To understand this further, we will see if paternal height is also associated with the mother's risk. If this is not the case, we can conclude that the effect does not go via fetal genes. To understand the effect of maternal height, we will also use results from another project where we have the genotype of 11,000 mother-father-child trios from the Norwegian Mother and Child Study (MoBa). We will calculate the so-called polygene risk score for height based on the genotypes. If this turns out to be associated with maternal risk of preeclampsia, we will have stronger evidence to say that there is a causal relationship between height and preeclampsia. This can lead us on the trail of the causes of this serious disease.

See the full project description at Cristin for more information about results, researchers, contact information etc.

Project participants

Project leader

Per Magnus, Norwegian Institute of Public Health

Project participants

Per Magnus, Senter for fruktbarhet og helse, Norwegian Institute of Public Health
Astanand Jugessur, Avdeling for genetikk og bioinformatikk, Norwegian Institute of Public Health
Øyvind Helgeland, Avdeling for genetikk og bioinformatikk, Norwegian Institute of Public Health

Start

15.06.2017

End

14.06.2021

Status

Active

Approvals

Regional committees for medical and health research ethics

Project owner/ Project manager

Norwegian Institute of Public Health

Responsible department

Centre for Fertility and Health

Project manager

Per Minor Magnus