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About the Respiratory Infections Study
How is the study conducted?
The study is a collaboration between the Norwegian Institute of Public Health and five Norwegian hospitals under the direction of the NorEPIS-network (Norwegian Enhanced Paediatric Immunisation Surveillance network).
All children aged 0-18 years who are referred to one of the study hospitals with fever and respiratory or other symptoms are invited to participate. Study participation requires written parental consent. A questionnaire is used to collect relevant health information about the study participants, such as symptoms, severity, and other parameters. Some participants are also followed up with a telephone interview after being discharged from the hospital. A nasopharyngeal sample is taken from each participant, which is tested for various viruses and bacteria at the hospital laboratory. The doctor who examines the child will usually request a nasopharyngeal sample to make a correct diagnosis and the same sample can be used in the study. Samples are sent to the laboratory at the Norwegian Institute of Public Health, where they will also be tested for several infectious agents.
Links to other registries
The study compiles data from questionnaires and test results with data from several other sources (Norwegian Patient Registry, Norwegian Immunisation Registry (SYSVAK), Medical Birth Registry, Norwegian Surveillance System for Communicable Diseases (MSIS), Control and Payment of Health Reimbursement (KUHR), Norwegian Prescription Database and Statistics Norway) to examine patients' use of health services, medicines and vaccines, vaccine efficacy, risk factors and possible complications from these infections.
The samples collected in the study are stored in a biobank at the Norwegian Institute of Public Health. The collected data are stored in an access-controlled and password-protected database, and only de-identified data are used in the analyses. At the end of the project, all data and samples are anonymised so study participants cannot be identified when the results are published. The estimated project end date is 31.12.2024.
The study is collaborating with a major European study (Pertinent- Pertussis in Infants European Network) to measure the disease burden and incidence of pertussis in Europe.
Funding and approval
The study is funded by the Research Council of Norway, the Norwegian Institute of Public Health and the European Centre for Disease Control and Prevention. The project leader is Dr. Elmira Flem at the Norwegian Institute of Public Health. The project is approved by the Regional Committee for Medical and Health Research Ethics.
Publication of results
Results from the study will be published in scientific journals and on the Norwegian Institute of Public Health’s website.
- Bøås H, Vázquez Fernández L, Bekkevold T, Rojahn AE, Bakken Kran AM, Størdal K, Molvig Debes S, Døllner D, Nordbø SA, Barstad B, Haarr E, Nakstad B, Leegaard TM, Flem E. Acute Respiratory Illness In Children: A New Hospital Surveillance System in Norway. 35th annual meeting of the European Society of Paediatric Infectious Diseases, Madrid, Spain May 23-27, 2017 (poster).
- Merdrignac L, Tozzi AE, Belchior E, Jané M, Krizova P, García Cenoz M, Cotter S, Flem E, Pandolfi E, Guillot S, Acosta L, Fabianova K, Díaz González J, O’Sullivan N, Bøås H, AïtBelghiti F, Valero-Rello A, Zavadilova J, Navascués A, Murphy J, Bekkevold T, Muñoz-Almagro C, Bacci S, Pastore Celentano L, Moren A and PERTINENT group. Pilot Season of Pertinent, A Novel Sentinal System to Measure the Burden of Pertussis in Hospitalised Infants in Eu/Eea. 35th annual meeting of the European Society of Paediatric Infectious Diseases, Madrid, Spain May 23-27, 2017 (poster).