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- MoBa Psychiatric Genetics. Identifying the missing heritability of psychiatric disorders combining hospital and population samples and leveraging novel analytical tools
Project
MoBa Psychiatric Genetics. Identifying the missing heritability of psychiatric disorders combining hospital and population samples and leveraging novel analytical tools - project description
Published
The project will study large cohorts and clinical materials to identify genetic risk factors and environmental factors across different psychiatric disorders.
Summary
The main goal in this study is to identify the genetic risk factors of psychiatric disorders (ADHD, autism spectrum disorder (ASD); major depressive disorders, schizophrenia, bipolar disorder, eating disorders, obsessive compulsive disorder (OCD), anxiety disorders and dementia) and interplay with environmental factors.
In addition, this study will attempt to identify more of the genetic architecture of mental disorders; apply novel statistical tools to improve the outcome of GWAS by applying polygenic and novel Bayesian statistical tools; apply long range phasing to identify rare gene variants in psychiatric disorders; determine shared genetic factors across psychiatric disorders and co-morbid diseases, including brain MRI variation; determine interaction between genetic and environment factors, in particular early environmental factors (pregnancy, neonatal and childhood/adolescence), and identify resilience factors.
Collaborating institutions:
- Norwegian Institute of Public Health
- University of Oslo