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  • Prenatal exposure to toxicants and childhood neurodevelopmental disorders and cognitive functions (NEUROTOX)

Project

Prenatal exposure to toxicants and childhood neurodevelopmental disorders and cognitive functions (NEUROTOX) - project description

Published Updated

To investigate if prenatal exposure to environmental toxicants disrupts normal fetal brain development, acting through thyroid and epigenetic mechanisms.


Summary

AIM: To investigate if prenatal exposure to environmental toxicants disrupts normal fetal brain development, acting through thyroid and epigenetic mechanisms.

Secondary aims
1. Investigate the general and differential effects of maternal toxicant levels during pregnancy on neurodevelopmental outcomes in the child: cognitive functions and diagnoses of ADHD, ASD, CP and epilepsy, including sub-phenotypes of these disorders (WP1)
2. Assess complex mixture effects of maternal levels of organic and inorganic neurotoxicants (perfluoroalkyl substances (PFAS) and metals) on neurodevelopmental outcome variables in children (WP2)
3. Investigate the relations between maternal neurotoxicant levels, neonatal thyroid hormone status, neonatal DNA methylationpatterns, and neurodevelopmental outcomes later in childhood (WP3)

See the full project description at Cristin for more information about results, researchers, contact information etc.

Project participants

Project leader

Heidi Aase, Norwegian Institute of Public Health

Project participants

Heidi Aase, Avdeling for barns helse og utvikling, Norwegian Institute of Public Health
Rachel Nethery, University of North Carolina at Chapel Hill
Amrit Kaur Sakhi, Avdeling for miljø og helse, Norwegian Institute of Public Health
Kjell Vegard Fjeldheim Weyde, Avdeling for barns helse og utvikling, Norwegian Institute of Public Health
Deborah Gordon Hirtz, University of Vermont
Esra Susser, Columbia University in the City of New York
Mady Hornig, Columbia University in the City of New York
R. Thomas Zoeller, University of Massachusetts at Amherst
Kristin Romvig Øvergaard, Oslo University Hospital
Camilla Stoltenberg, Norwegian Institute of Public Health
Ragnihild Brandlistuen, Norwegian Institute of Public Health
Per Minor Magnus, Senter for fruktbarhet og helse, Norwegian Institute of Public Health
Tiril Cecilie Borge, Avdeling for barns helse og utvikling, Norwegian Institute of Public Health
Ida Henriette Caspersen, Avdeling for miljø og helse, Norwegian Institute of Public Health
Line Småstuen Haug, Avdeling for miljø og helse, Norwegian Institute of Public Health
Cathrine Thomsen, Avdeling for miljø og helse, Norwegian Institute of Public Health
Yankai Xia, Nanjing Medical University
Ian Lipkin, Columbia University in the City of New York
Guro Lillemoen Andersen, Norwegian University of Science and Technology

Start

01.07.2012

End

31.12.2024

Status

Active

Approvals

Regional committees for medical and health research ethics

Project owner/ Project manager

Norwegian Institute of Public Health

Project manager

Heidi Aase