Prenatal exposure to toxicants and childhood neurodevelopmental disorders and cognitive functions (NEUROTOX)
Project
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To investigate if prenatal exposure to environmental toxicants disrupts normal fetal brain development, acting through thyroid and epigenetic mechanisms.
Summary
AIM: To investigate if prenatal exposure to environmental toxicants disrupts normal fetal brain development, acting through thyroid and epigenetic mechanisms.
Secondary aims
1. Investigate the general and differential effects of maternal toxicant levels during pregnancy on neurodevelopmental outcomes in the child: cognitive functions and diagnoses of ADHD, ASD, CP and epilepsy, including sub-phenotypes of these disorders (WP1)
2. Assess complex mixture effects of maternal levels of organic and inorganic neurotoxicants (perfluoroalkyl substances (PFAS) and metals) on neurodevelopmental outcome variables in children (WP2)
3. Investigate the relations between maternal neurotoxicant levels, neonatal thyroid hormone status, neonatal DNA methylationpatterns, and neurodevelopmental outcomes later in childhood (WP3)
Project leader
Gro Dehli Andersen, Norwegian Institute of Public Health
Project participants
Heidi Aase, Child Health and Development, Norwegian Institute of Public Health
Rachel Nethery, University of North Carolina at Chapel Hill
Amrit Kaur Sakhi, Infection Control, Norwegian Institute of Public Health
Kjell Vegard Fjeldheim Weyde, Child Health and Development, Norwegian Institute of Public Health
Deborah Gordon Hirtz, University of Vermont
Esra Susser, Columbia University in the City of New York
Mady Hornig, Columbia University in the City of New York
R. Thomas Zoeller, University of Massachusetts at Amherst
Kristin Romvig Øvergaard, Oslo University Hospital
Ragnihild Brandlistuen, Norwegian Institute of Public Health
Per Minor Magnus, Centre for Fertility and Health, Norwegian Institute of Public Health
Tiril Cecilie Borge, Child Health and Development, Norwegian Institute of Public Health
Ida Henriette Caspersen, Infection Control, Norwegian Institute of Public Health
Line Småstuen Haug, Infection Control, Norwegian Institute of Public Health
Cathrine Thomsen, Infection Control, Norwegian Institute of Public Health
Yankai Xia, Nanjing Medical University
Ian Lipkin, Columbia University in the City of New York
Guro Lillemoen Andersen, Norwegian University of Science and Technology
About the project
Start
01.07.2012
End
31.12.2025
Status
Active
Approvals
Regional committees for medical and health research ethics
Project owner/ Project manager
Norwegian Institute of Public Health