MoBa-PlastChem: Prenatal exposure to plastic chemicals and reproductive health in children and adolescents from the Norwegian Mother, Father and Child Cohort Study
Project
|Updated
The purpose of this study is to investigate whether prenatal exposure to environmental toxicants, originating from plastic production or products, is associated with reproductive health problems in children and adolescents.
Summary
Pregnant women are daily exposed (via food, drink, consumer products and air) to many plastic chemicals that can interfere with sex hormones and reproductive development in the fetus and contribute to poorer reproductive health in children, adolescents and later life phases (e.g. malformations of the genitals, altered puberty development, poorer sperm quality, lower fertility, etc.). Although such associations have been demonstrated in animal studies, there is little epidemiological data from longitudinal studies. The purpose of this study is to investigate whether prenatal exposure to environmental toxicants, originating from plastic production or products (phenols, organophosphate flame retardants, phthalates and per- and polyfluoroalkyl substances), is associated with reproductive health problems in children and adolescents. More specifically, we investigate whether the pollutants are related to 1) Risk of hypospadias and cryptorchidism in male children or 2) changes in pubertal development in boys and girls.
Project leader
Gro Dehli Villanger, Norwegian Institute of Public Health
Project participants
Christos Symeonides, Minderoo Foundation
Sarah Dunlop, Minderoo Foundation
Stephanie Engel, University of North Carolina at Chapel Hill
Anne Lise Brantsæter, Food Safety, Norwegian Institute of Public Health
Cathrine Thomsen, Food Safety, Norwegian Institute of Public Health
Line Småstuen Haug, Food Safety, Norwegian Institute of Public Health
Amrit Kaur Sakhi, Food Safety, Norwegian Institute of Public Health
Ragnhild Eek Brandlistuen, Child Health and Development, Norwegian Institute of Public Health
Guido Biele, Child Health and Development, Norwegian Institute of Public Health
Mari Landås Warp, Centre for Fertility and Health, Norwegian Institute of Public Health
Hans Ivar Hanevik, Centre for Fertility and Health, Norwegian Institute of Public Health
Thea Karoline Walstad Grindstad, Centre for Fertility and Health, Norwegian Institute of Public Health
Ida Henriette Caspersen, Centre for Fertility and Health, Norwegian Institute of Public Health
Adriano Winterton, Child Health and Development, Norwegian Institute of Public Health
Siri Eldevik Håberg, Centre for Fertility and Health, Norwegian Institute of Public Health
Maria Christine Magnus, Centre for Fertility and Health, Norwegian Institute of Public Health
Per Minor Magnus, Centre for Fertility and Health, Norwegian Institute of Public Health
Thea Steen Skogheim, Health Services Research, Norwegian Institute of Public Health
Heidi Aase, Child Health and Development, Norwegian Institute of Public Health
Start
01.01.2023
End
31.12.2025
Status
Active
Approvals
Regional committees for medical and health research ethics
Project owner/ Project manager
Norwegian Institute of Public Health
