Evaluering av sikkerhet og effekt for Ebola vaksine i et distrikt i Guinea

Summary

The current outbreak of Ebola Virus Disease (EVD) in West Africa is by far the largest outbreak ever recorded. The WHO meeting in sept-14 has proposed to fast-track clinical Ebola vaccine trials. This study has the potential to contribute to control the Ebola epidemic in West Africa and possibly prevent new, future outbreaks. The study aims to evaluate Ebola vaccine efficacy and the use of ring vaccination as a vaccine delivery strategy in a population in West Africa. In addition, it will offer vaccination to frontline workers. The study will also give more information on safety and immunogenicity of the vaccine, and possibly contribute to the establishment of a correlate of protection. The planned research will strengthen the capacity of conducting high quality research in Guinea through an international collaboration and engagement of the local community and authorities of Guinea. Furthermore, the study may help to design implementation strategy of Ebola vaccines in West Africa.