Robert Lyle
Senior Scientist
Contact
Send email {model.translations.sendEmailTo} robert.lyle@medisin.uio.no
https://www.sequencing.uio.no/about/people/robert-lyle.html
Department
Background
Robert Lyle is Core Facility Leader and Senior Scientist at the Norwegian Sequencing Centre at the University of Oslo. He is an Affiliated Researcher at the Centre for Fertility and Health. He has a BSc in Genetics and a PhD in Human Genetics.
Projects and publications
- Siri Nærland Skodvin, Håkon K. Gjessing, Astanand Jugessur, Julia Romanowska, Alexandra Havdahl, Siri Eldevik Håberg, Hans Ivar Hanevik, Robert Lyle, Rolv T. Lie, Miriam Gjerdevik, (2025). Genome-Wide Association Analyses in Family Triads and Dyads Following Assisted Reproductive Technology. Genetic Epidemiology doi: 10.1002/gepi.70011
- Laura L. Oakley, Dana Kristjansson, Monica Cheng Munthe-Kaas, Huong Thu Nguyen, Yunsung Lee, Hans Ivar Hanevik, Liv Bente Bergem Romundstad, Robert Lyle, Siri Eldevik Håberg, (2024). Sex differences in childhood cancer risk following ART conception: a registry-based study. Human Reproduction s. 382-390. doi: 10.1093/humrep/deae285
- Dana Kristjansson, Yunsung Lee, Christian Magnus Page, Håkon K. Gjessing, Maria Christine Magnus, Astanand Jugessur, Robert Lyle, Siri Eldevik Håberg, (2024). Sex differences in DNA methylation variations according to ART conception-evidence from the Norwegian mother, father, and child cohort study. Scientific Reports doi: 10.1038/s41598-024-73845-3
- Mari Roberts Spildrejorde, Magnus Leithaug, Athina Samara, Hans Christian Aass, Ankush Sharma, Ganesh Acharya, Hedvig Marie Egeland Nordeng, Kristina Gervin, Robert Lyle, (2024). Citalopram exposure of hESCs during neuronal differentiation identifies dysregulated genes involved in neurodevelopment and depression. Frontiers in Cell and Developmental Biology doi: 10.3389/fcell.2024.1428538
- Sina Rostami, Trine B. Rounge, Luca Pestarino, Robert Lyle, Reneé Turzanski Fortner, Øystein Ariansen Haaland, Rolv T. Lie, Fredrik Wiklund, Tone Bjørge, Hilde Langseth, (2024). Differential levels of circulating RNAs prior to endometrial cancer diagnosis. International Journal of Cancer s. 946-956. doi: 10.1002/ijc.34951
- Mari Spildrejorde, Athina Samara, Ankush Sharma, Magnus Leithaug, Martin Bengt Alfred Falck, Stefania Modafferi, Arvind Y.M. Sundaram, Ganesh Acharya, Hedvig Marie Egeland Nordeng, Ragnhild Eskeland, Kristina Gervin, Robert Lyle, (2023). Multi-omics approach reveals dysregulated genes during hESCs neuronal differentiation exposure to paracetamol. iScience s. 1-29. doi: 10.1016/j.isci.2023.107755
- Emilie Willoch Olstad, Hedvig Marie Egeland Nordeng, Robert Lyle, Kristina Gervin, (2023). No impact of prenatal paracetamol and folic acid exposure on cord blood DNA methylation in children with attention-deficit/hyperactivity disorder. Frontiers in Genetics s. 1-6. doi: 10.3389/fgene.2023.1204879
- Emilie Willoch Olstad, Hedvig Marie Egeland Nordeng, Geir Kjetil Ferkingstad Sandve, Robert Lyle, Kristina Gervin, (2023). Effects of prenatal exposure to (es)citalopram and maternal depression during pregnancy on DNA methylation and child neurodevelopment. Translational Psychiatry doi: 10.1038/s41398-023-02441-2
- Julia Romanowska, Haakon Egdetveit Nustad, Christian Magnus Page, William Robert Paul Denault, Yunsung Lee, Maria Christine Magnus, Kristine Løkås Haftorn, Miriam Gjerdevik, Boris Novakovic, Richard Saffery, Håkon K. Gjessing, Robert Lyle, Per Minor Magnus, Siri Eldevik Håberg, Astanand Jugessur, (2023). The X-factor in ART: does the use of assisted reproductive technologies influence DNA methylation on the X chromosome?. Human Genomics doi: 10.1186/s40246-023-00484-6
- Kristine Løkås Haftorn, William Robert Paul Denault, Yunsung Lee, Christian Magnus Page, Julia Romanowska, Robert Lyle, Øyvind Erik Næss, Dana Kristjansson, Per Minor Magnus, Siri Eldevik Håberg, Jon Bohlin, Astanand Jugessur, (2023). Nucleated red blood cells explain most of the association between DNA methylation and gestational age. Communications Biology doi: 10.1038/s42003-023-04584-w
- Julia Romanowska, Haakon Nustad, Christian Magnus Page, William Robert Paul Denault, Jon Bohlin, Yunsung Lee, maria magnus, Kristine Løkås Haftorn, Miriam Gjerdevik, Boris Novakovic, Richard Saffrey, Håkon Gjessing, Robert Lyle, Per Magnus, Siri Eldevik Håberg, Astanand Jugessur, (2022). The X-factor in ART: does the use of Assisted Reproductive Technologies influence DNA methylation on the X chromosome?. bioRxiv doi: 10.1101/2022.10.06.510603
- Theodora Kunovac Kallak, Emma Fransson, Emma Bränn, Hanna Berglund, Susanne Lager, Erika Comasco, Robert Lyle, Alkistis Skalkidou, (2022). Maternal prenatal depressive symptoms and toddler behavior: an umbilical cord blood epigenome-wide association study. Translational Psychiatry doi: 10.1038/s41398-022-01954-6
- Athina Samara, Mari Spildrejorde, Ankush Sharma, Martin Falck, Magnus Leithaug, Stefania Modafferi, Pål Marius Bjørnstad, Acharya Ganesh, Kristina Gervin, Robert Lyle, Ragnhild Eskeland, (2022). A multi-omics approach to visualize early neuronal differentiation from hESCs in 4D. iScience doi: 10.1016/j.isci.2022.105279
- Haakon Egdetveit Nustad, Ingelin Steinsland, Miina Ollikainen, Emma Cazaly, Jaakko Kaprio, Yuval Benjamini, Kristina Gervin, Robert Lyle, (2022). Modeling dependency structures in 450k DNA methylation data. Bioinformatics s. 885-891. doi: 10.1093/bioinformatics/btab774
- Emilie Willoch Olstad, Hedvig Marie Egeland Nordeng, Geir Kjetil Ferkingstad Sandve, Robert Lyle, Kristina Gervin, (2022). Low reliability of DNA methylation across Illumina Infinium platforms in cord blood: implications for replication studies and meta-analyses of prenatal exposures. Clinical Epigenetics doi: 10.1186/s13148-022-01299-3
- Ajay Yadav, Steven Verhaegen, Panagiotis Filis, Diana Domanska, Robert Lyle, Arvind Sundaram, Magnus Leithaug, Gunn Charlotte Østby, Mona Aleksandersen, Hanne Friis Berntsen, Karin Elisabeth Zimmer, Paul A. Fowler, Ragnhild Elisabeth Heimtun Paulsen, Erik Ropstad, (2022). Exposure to a human relevant mixture of persistent organic pollutants or to perfluorooctane sulfonic acid alone dysregulates the developing cerebellum of chicken embryo. Environment International s. 1-13. doi: 10.1016/j.envint.2022.107379
- Sinan Ugur Umu, Hilde Langseth, Verena Zuber, Åslaug Helland, Robert Lyle, Trine Ballestad Rounge, (2022). Serum RNAs can predict lung cancer up to 10 years prior to diagnosis. eLIFE doi: 10.7554/ELIFE.71035
- Siri Eldevik Håberg, Christian Magnus Page, Yunsung Lee, Haakon Egdetveit Nustad, Maria Christine Magnus, Kristine Løkås Haftorn, Ellen Øen Carlsen, William Robert Paul Denault, Jon Bohlin, Astanand Jugessur, Per Minor Magnus, Håkon Kristian Gjessing, Robert Lyle, (2022). DNA methylation in newborns conceived by assisted reproductive technology. Nature Communications s. 1-12. doi: 10.1038/s41467-022-29540-w
- Marcin Wojewodzic, Magnus Leithaug, Marianne Lauritzen, Robert Lyle, Sofia Haglund, Carl-Johan Rubin, Philip A. Ewels, Tom Grotmol, Trine Ballestad Rounge, (2021). Ultralow amounts of DNA from long-term archived serum samples produce high-quality methylomes. Clinical Epigenetics doi: 10.1186/s13148-021-01097-3
- William Robert Paul Denault, Julia Romanowska, Øystein Ariansen Haaland, Robert Lyle, Jack A. Taylor, Zongli Xu, Rolv T. Lie, Håkon K. Gjessing, Astanand Jugessur, (2021). Wavelet Screening identifies regions highly enriched for differentially methylated loci for orofacial clefts. NAR Genomics and Bioinformatics s. 1-16. doi: 10.1093/nargab/lqab035
- Kristine Løkås Haftorn, Yunsung Lee, William Robert Paul Denault, Christian Magnus Page, Haakon Egdetveit Nustad, Robert Lyle, Håkon Kristian Gjessing, Anni Malmberg, Maria Christine Magnus, Øyvind Erik Næss, Darina Czamara, Katri Räikkönen, Jari Lahti, Per Minor Magnus, Siri Eldevik Håberg, Astanand Jugessur, Jon Bohlin, (2021). An EPIC predictor of gestational age and its application to newborns conceived by assisted reproductive technologies. Clinical Epigenetics doi: 10.1186/s13148-021-01055-z
- Ane Sørlie Kværner, Einar Elvbakken Birkeland, Cecilie Bucher-Johannessen, Elina Vinberg, Jan Inge Nordby, Harri Kangas, Vahid Bemanian, Pekka Ellonen, Edoardo Botteri, Erik Natvig, Torbjørn Rognes, Eivind Hovig, Robert Lyle, Ole Herman Ambur, Willem M. de Vos, Scott J Bultman, Anette Hjartåker, Rikard Landberg, Mingyang Song, Hege Salvesen Blix, Giske Ursin, Kristin Ranheim Randel, Thomas de Lange, Geir Hoff, Øyvind Holme, Paula Berstad, Trine Ballestad Rounge, (2021). The CRCbiome study: a large prospective cohort study examining the role of lifestyle and the gut microbiome in colorectal cancer screening participants. BMC Cancer doi: 10.1186/s12885-021-08640-8
- Theodora Kunovac Kallak, Emma Bränn, Emma Fransson, Åsa Johansson, Susanne Lager, Erika Comasco, Robert Lyle, Alkistis Skalkidou, (2021). DNA methylation in cord blood in association with prenatal depressive symptoms. Clinical Epigenetics doi: 10.1186/s13148-021-01054-0
- Yunsung Lee, Kristine Løkås Jacobsen, William Robert Paul Denault, Haakon Egdetveit Nustad, Christian Page, Robert Lyle, Sindre Lee-Ødegård, Gunn-Helen Moen, Rashmi B. Prasad, Leif C. Groop, Line Sletner, Christine Sommer, Maria Christine Magnus, Håkon K. Gjessing, Jennifer Ruth Harris, Per Magnus, Siri Eldevik Håberg, Astanand Jugessur, Jon Bohlin, (2020). Blood-based epigenetic estimators of chronological age in human adults using DNA methylation data from the Illumina MethylationEPIC array. BMC Genomics doi: 10.1186/s12864-020-07168-8
- Sinan Uğur Umu, Hilde Langseth, Andreas Keller, Eckart Meese, Åslaug Helland, Robert Lyle, Trine Ballestad Rounge, (2019). A 10-year prediagnostic follow-up study shows that serum RNA signals are highly dynamic in lung carcinogenesis. Molecular Oncology s. 235-247. doi: 10.1002/1878-0261.12620
- Abdolrahman Khezri, Birgitte Narud, Else-Berit Stenseth, Anders Johannisson, Frøydis Deinboll Myromslien, Ann Helen Gaustad, Robert Charles Wilson, Robert Lyle, Jane Morrell, Elisabeth Kommisrud, Rafi Ahmad, (2019). DNA methylation patterns vary in boar sperm cells with different levels of DNA fragmentation. BMC Genomics s. 1-15. doi: 10.1186/s12864-019-6307-8
- Kristina Gervin, Lucas A. Salas, Kelly M. Bakulski, Menno C. van Zelm, Devin C. Koestler, John K Wiencke, Liesbeth Duijts, Henriette A Moll, Karl T Kelsey, Michael S. Kobor, Robert Lyle, Brock C. Christensen, Janine F Felix, Meaghan J. Jones, (2019). Systematic evaluation and validation of reference and library selection methods for deconvolution of cord blood DNA methylation data. Clinical Epigenetics doi: 10.1186/s13148-019-0717-y
- Trine Ballestad Rounge, Sinan Uğur Umu, Andreas Keller, Eckart Meese, Giske Ursin, Steinar Tretli, Robert Lyle, Hilde Langseth, (2018). Circulating small non-coding RNAs associated with age, sex, smoking, body mass and physical activity. Scientific Reports doi: 10.1038/s41598-018-35974-4
- Sinan Ugur Umu, Hilde Langseth, Cecilie Bucher-Johannessen, Bastian Fromm, Andreas Keller, Eckart Meese, Marianne Lauritzen, Magnus Leithaug, Robert Lyle, Trine Ballestad Rounge, (2018). A comprehensive profile of circulating RNAs in human serum. RNA Biology s. 242-250. doi: 10.1080/15476286.2017.1403003
- Kristina Gervin, Hedvig Marie Egeland Nordeng, Ragnhild Eskeland, Ragnhild Elisabeth Paulsen, Robert Lyle, (2017). Farmakoepigenetikk: Samspillet mellom legemidler og epigenetikk. Norsk Farmaceutisk Tidsskrift (NFT) s. 30-34.
- Kristina Gervin, Hedvig Marie Egeland Nordeng, Eivind Ystrøm, Ted Reichborn-Kjennerud, Robert Lyle, (2017). Long-term prenatal exposure to paracetamol is associated with DNA methylation differences in children diagnosed with ADHD. Clinical Epigenetics doi: 10.1186/s13148-017-0376-9
- Sjur Reppe, Tonje Gulbrandsen Lien, Yi-Hsiang Hsu, Vigdis Teig Gautvik, Ole Kristoffer Olstad, Rona Yu, Hege Gilbø Bakke, Robert Lyle, Marianne K. Kringen, Ingrid Kristine Glad, Kaare M Gautvik, (2017). Distinct DNA methylation profiles in bone and blood of osteoporotic and healthy postmenopausal women. Epigenetics s. 674-687. doi: 10.1080/15592294.2017.1345832
- Eirik Natås Hanssen, Robert Lyle, Thore Egeland, Peter Gill, (2017). Degradation in forensic trace DNA samples explored by massively parallel sequencing. Forensic Science International: Genetics s. 160-166. doi: 10.1016/j.fsigen.2017.01.002
- Xavier Tekpli, Alfonso Urbanucci, Adnan Hashim, Cathrine Broberg Vågbø, Robert Lyle, Marianne K. Kringen, Anne Cathrine Staff, Ingunn Dybedal, Ian Geoffrey Mills, Arne Klungland, Judith Staerk, (2016). Changes of 5-hydroxymethylcytosine distribution during myeloid and lymphoid differentiation of CD34+ cells. Epigenetics & Chromatin doi: 10.1186/s13072-016-0070-8
- Anders J Svendsen, Kristina Gervin, Robert Lyle, Lene Christiansen, Kirsten Kyvik, Peter Junker, Christian Nielsen, Gunnar Houen, Qihua Tan, (2016). Differentially methylated DNA regions in monozygotic twin pairs discordant for rheumatoid arthritis: An epigenome-wide study. Frontiers in Immunology doi: 10.3389/fimmu.2016.00510
- Hanne Sørmo Sorte, Liv T. N. Osnes, Børre Fevang, Pål Aukrust, Hans Christian Erichsen, Paul Hoff Backe, Tore G Abrahamsen, Ole Bjørn Kittang, Torstein Øverland, Shalini N. Jhangiani, Donna M. Muzny, Magnus Dehli Vigeland, Pubudu Saneth Samarakoon, Tomasz Gambin, Zeynep H.C. Akdemir, Richard A. Gibbs, Olaug Kristin Rødningen, Robert Lyle, James R. Lupski, Asbjørg Stray-Pedersen, (2016). A potential founder variant in CARMIL2/RLTPR in three Norwegian families with warts, molluscum contagiosum, and T-cell dysfunction. Molecular Genetics & Genomic Medicine s. 604-616. doi: 10.1002/mgg3.237
- Ellen Wikenius, Vibeke Moe, Marian Kjellevold Malde, Lars Smith, Robert Lyle, Rune Waagbø, Christian Page, Anne Margrethe Myhre, (2016). The association between hair cortisol and self-reported symptoms of depression in pregnant women. PLOS ONE doi: 10.1371/journal.pone.0161804
- Kristina Gervin, Bettina Kulle, Hanne Sagsveen Hjorthaug, Karin C. Lødrup Carlsen, Kai-Håkon Carlsen, Dag Erik Undlien, Robert Lyle, Monica Cheng Munthe-Kaas, (2016). Intra-individual changes in DNA methylation not mediated by cell-type composition are correlated with aging during childhood. Clinical Epigenetics s. 1-12. doi: 10.1186/s13148-016-0277-3
- Arvind Sundaram, Timothy Hughes, Shea Biondi, Nathalie Bolduc, Sarah K Bowman, Andrew Camilli, Yap C Chew, Catherine Couture, Andrew Farmer, John P Jerome, David W Lazinski, Andrew McUsic, Xu Peng, Kamran Shazand, Feng Xu, Robert Lyle, Gregor Duncan Gilfillan, (2016). A comparative study of ChIP-seq sequencing library preparation methods. BMC Genomics doi: 10.1186/s12864-016-3135-y
- Kristina Gervin, Christian Page, Hans Christian Aass, Michelle A Jansen, Heidi Fjeldstad, Bettina Kulle Andreassen, Liesbeth Duijts, Joyce B van Meurs, Menno C van Zelm, Vincent W Jaddoe, Hedvig Marie Egeland Nordeng, Gun Peggy Knudsen, Per Magnus, Wenche Nystad, Anne Cathrine Staff, Janine F Felix, Robert Lyle, (2016). Cell type specific DNA methylation in cord blood: a 450K-reference data set and cell count-based validation of estimated cell type composition. Epigenetics s. 690-698. doi: 10.1080/15592294.2016.1214782
- Tove Lekva, Robert Lyle, Marie Cecilie Paasche, Camilla Margrethe Friis, Diana W. Bianchi, Iris Z. Jaffe, Errol R. Norwitz, Jens Bollerslev, Tore Henriksen, Thor Ueland, (2016). Gene expression in term placentas is regulated more by spinal or epidural anesthesia than by late-onset preeclampsia or gestational diabetes mellitus. Scientific Reports doi: 10.1038/srep29715
- KH Pietilainen, K Ismail, E Järvinen, Seppo Heinonen, Marcia Tummers, S Bollepalli, Robert Lyle, M Muniandy, E Moilanen, A Hakkarainen, J Lundbom, Nina Lundbom, A Rissanen, J Kaprio, Markku Ollikainen, (2016). DNA methylation and gene expression patterns in adipose tissue differ significantly within young adult monozygotic BMI-discordant twin pairs. International Journal of Obesity s. 654-661. doi: 10.1038/ijo.2015.221
- Pubudu Saneth Samarakoon, Hanne Sørmo Sorte, Asbjørg Stray-Pedersen, Olaug Kristin Rødningen, Torbjørn Rognes, Robert Lyle, (2016). cnvScan: A CNV screening and annotation tool to improve the clinical utility of computational CNV prediction from exome sequencing data. BMC Genomics doi: 10.1186/s12864-016-2374-2
- Gonneke Willemsen, Kirsten J. Ward, Christopher G. Bell, Kaare Christensen, Jocelyn Bowden, Christine Dalgård, Jennifer Harris, Jaakko Kaprio, Robert Lyle, Patrik K.E. Magnusson, Karen A. Mather, Juan R. Ordoňana, Francisco Perez-Riquelme, Nancy L. Pedersen, Kirsi H. Pietiläinen, Perminder S. Sachdev, Dorret I. Boomsma, Tim Spector, (2015). The Concordance and Heritability of Type 2 Diabetes in 34,166 twin pairs from international twin registers: The Discordant Twin (DISCOTWIN) Consortium. Twin Research and Human Genetics s. 762-771. doi: 10.1017/thg.2015.83
- Trine Ballestad Rounge, Marianne Lauritzen, Hilde Langseth, Espen Enerly, Robert Lyle, Randi Elin Gislefoss, (2015). MicroRNA biomarker discovery and high-throughput DNA sequencing are possible using long-term archived serum samples. Cancer Epidemiology, Biomarkers and Prevention s. 1381-1387. doi: 10.1158/1055-9965.EPI-15-0289
- Tove Lekva, Jens Petter Berg, Robert Lyle, Ansgar Heck, Jens Bollerslev, Thor Ueland, (2015). Alternative splicing of placental lactogen (CSH2) in somatotroph pituitary adenomas. Neuro - endocrinology letters s. 136-142.
- M Ollikainen, K Ismail, Kristina Gervin, Jennifer Harris, Robert Lyle, Anjuska Kyllönen, A Hakkarainen, J Lundbom, A Jarvinen, Nina Lundbom, Aila Rissanen, Kirsi H. Pietiläinen, Jaakko Kaprio, (2015). Genome-wide blood DNA methylation alterations at regulatory elements and heterochromatic regions in monozygotic twins discordant for obesity and liver fat. Clinical Epigenetics s. 1-13. doi: 10.1186/s13148-015-0073-5
- Sjur Reppe, Agate Noer, Runa Marie Grimholt, Bjarni V Halldorsson, Carolina Medina-Gomez, Vigdis Teig Gautvik, Ole Kristoffer Olstad, Harish K Datta, Jens Petter Berg, Karol Estrada, Albert Hofman, André G. Uitterlinden, Fernando Rivadeneira, Robert Lyle, Philippe Collas, Kaare M Gautvik, (2015). Methylation of bone SOST, its mRNA, and serum sclerostin levels correlate strongly with fracture risk in postmenopausal women. Journal of Bone and Mineral Research s. 249-256. doi: 10.1002/jbmr.2342
- Mario Leonardo Squadrito, Caroline Baer, Frédéric Burdet, Claudio Maderna, Gregor Duncan Gilfillan, Robert Lyle, Mark Ibberson, Michele De Palma, (2014). Endogenous RNAs Modulate MicroRNA Sorting to Exosomes and Transfer to Acceptor Cells. Cell reports s. 1432-1446. doi: 10.1016/j.celrep.2014.07.035
- Camilla Stormo, Marianne Kristiansen, Robert Lyle, Ole Kristoffer Olstad, Daniel Sachse, Jens Petter Berg, Armin Piehler, (2014). RNA-sequencing analysis of HepG2 cells treated with atorvastatin. PLOS ONE doi: 10.1371/journal.pone.0105836
- Mina Susanne Weedon-Fekjær, Ying Sheng, Meryam Sugulle, Guro Mørk Johnsen, F Herse, Christopher W.G. Redman, Robert Lyle, Ralf Dechend, Anne Cathrine Staff, (2014). Placental miR-1301 is dysregulated in early-onset preeclampsia and inversely correlated with maternal circulating leptin. Placenta s. 709-717. doi: 10.1016/j.placenta.2014.07.002
- Pubudu Saneth Samarakoon, Hanne Sørmo Sorte, Bjørn Evert Kristiansen, Tove Skodje, Ying Sheng, Geir Erland Tjønnfjord, Barbro Stadheim, Asbjørg Stray-Pedersen, Olaug Kristin Rødningen, Robert Lyle, (2014). Identification of copy number variants from exome sequence data. BMC Genomics doi: 10.1186/1471-2164-15-661
- Doriana Misceo, Asbjørn Holmgren, William Edward Louch, Pål Andre Holme, Masahiro Mizobuchi, Raul J. Morales, André Maues De Paula, Asbjørg Stray-Pedersen, Robert Lyle, Bjørn Dalhus, Geir Arve Christensen, Helge Stormorken, Geir Erland Tjønnfjord, Eirik Frengen, (2014). A Dominant STIM1 Mutation Causes Stormorken Syndrome. Human Mutation s. 556-564. doi: 10.1002/humu.22544
- Javier Pena Diaz, Siv Anita Hegre, Endre Anderssen, Per Arne Aas, Robin Mjelle, Gregor Duncan Gilfillan, Robert Lyle, Finn Drabløs, Hans Einar Krokan, Pål Sætrom, (2013). Transcription profiling during the cell cycle shows that a subset of Polycomb-targeted genes is upregulated during DNA replication. Nucleic Acids Research (NAR) s. 2846-2856. doi: 10.1093/nar/gks1336
- Thomas Sevenius Nilsen, Gun Peggy Knudsen, Kristina Gervin, Ingunn Brandt, Espen Røysamb, Kristian Tambs, Ragnhild Ørstavik, Robert Lyle, Ted Reichborn-Kjennerud, Per Magnus, Jennifer Harris, (2013). The Norwegian twin registry from a public health perspective: a research update. Twin Research and Human Genetics s. 285-295. doi: 10.1017/thg.2012.117
- Tove Lekva, Jens Petter Berg, Robert Lyle, Ansgar Heck, Geir Andre Ringstad, Ole Kristoffer Olstad, Annika Michelsen, Olivera Casar-Borota, Jens Bollerslev, Thor Ueland, (2013). Epithelial Splicing Regulator Protein 1 and Alternative Splicing in Somatotroph Adenomas. Endocrinology s. 3331-3343. doi: 10.1210/en.2013-1051
- Mario Leonardo Squadrito, Ferdinando Pucci, Laura Magri, Davide Moi, Gregor Duncan Gilfillan, Anna Ranghetti, Andrea Casazza, Massimiliano Mazzone, Robert Lyle, Luigi Naldini, Michele De Palma, (2012). miR-511-3p Modulates Genetic Programs of Tumor-Associated Macrophages. Cell reports s. 141-154. doi: 10.1016/j.celrep.2011.12.005
- Andreas Leidenroth, Hanne Sørmo Sorte, Gregor Duncan Gilfillan, Melanie Ehrlich, Robert Lyle, Jane E. Hewitt, (2012). Diagnosis by sequencing: correction of misdiagnosis from FSHD2 to LGMD2A by whole-exome analysis. European Journal of Human Genetics s. 999-1003. doi: 10.1038/ejhg.2012.42
- Gregor Duncan Gilfillan, Timothy Hughes, Ying Sheng, Hanne Sagsveen Hjorthaug, Tobias Straub, Kristina Gervin, Jennifer Harris, Dag Erik Undlien, Robert Lyle, (2012). Limitations and possibilities of low cell number ChIP-seq. BMC Genomics doi: 10.1186/1471-2164-13-645
- Monica Cheng Munthe-Kaas, Randi Jacobsen Bertelsen, Tale Mæhre Torjussen, Hanne Sagsveen Hjorthaug, Dag Erik Undlien, Robert Lyle, Kristina Gervin, Berit Granum, Petter Mowinckel, Kai-Håkon Carlsen, Karin C. Lødrup Carlsen, (2012). Pet keeping and tobacco exposure influence CD14 methylation in childhood. Pediatric Allergy and Immunology s. 746-753. doi: 10.1111/pai.12021
- Hanne Sørmo Sorte, Lars Mørkrid, Olaug Kristin Rødningen, Mari Ann Kulseth, Asbjørg Stray-Pedersen, Gert Matthijs, Valerie Race, Gunnar Houge, Torunn Fiskerstrand, Bjørn Bjurulf, Robert Lyle, Trine Prescon, (2012). Severe ALG8-CDG (CDG-Ih) associated with homozygosity for two novel missense mutations detected by exome sequencing of candidate genes. European Journal of Medical Genetics s. 196-202. doi: 10.1016/j.ejmg.2012.01.003
- LA Forsberg, C Rasi, HR Razzaghian, G Pakalapati, L Waite, KS Thilbeault, A Ronowicz, NE Wineinger, HK Tiwari, D Boomsma, MP Westerman, Jennifer Harris, Robert Lyle, M Essand, F Eriksson, TL Assimes, C Iribarren, E Strachan, TP O'Hanlon, LG Rider, FW Miller, V Giedraitis, L Lannfelt, A Piotrowski, M Ingelsson, NL Pedersen, D Absher, JP Dumanski, (2012). Age-Related Somatic Structural Changes in the Nuclear Genome of Human Blood Cells. American Journal of Human Genetics s. 217-228. doi: 10.1016/j.ajhg.2011.12.009
- Kristina Gervin, Magnus Dehli Vigeland, Morten Mattingsdal, Martin Hammerø, Heidi Nygård, Anne Olaug Olsen, Ingunn Brandt, Jennifer Harris, Dag Erik Undlien, Robert Lyle, (2012). DNA Methylation and Gene Expression Changes in Monozygotic Twins Discordant for Psoriasis: Identification of Epigenetically Dysregulated Genes. PLoS Genetics doi: 10.1371/journal.pgen.1002454
- Jitka Stilund Hansen, Unni Cecilie Nygaard, Robert Lyle, Martinus Løvik, (2012). Early life interventions to prevent allergy in the offspring: the role of maternal immunization and postnatal mucosal allergen exposure. International Archives of Allergy and Immunology s. 261-275. doi: 10.1159/000332963
- Kaja Kristine Selmer, Gregor Duncan Gilfillan, Petter Strømme, Robert Lyle, Timothy Hughes, Hanne Sagsveen Hjorthaug, Kristin Brandal, Sigve Nakken, Doriana Misceo, Thore Egeland, Ludvig Andre Munthe, Sigrun Kierulf Brækken, Dag Erik Undlien, (2012). A mild form of Mucopolysaccharidosis IIIB diagnosed with targeted next-generation sequencing of linked genomic regions. European Journal of Human Genetics s. 58-63. doi: 10.1038/ejhg.2011.126
- Mari Ann Kulseth, Robert Lyle, Olaug Kristin Rødningen, Hanne Sørmo Sorte, Trine Prescon, (2011). Exon trapping analysis of c.301-19G > A in intron 1 of the SHH gene in a patient with a microform of holoprosencephaly. European Journal of Medical Genetics s. 130-135. doi: 10.1016/j.ejmg.2010.10.011
- Kristina Gervin, Martin Hammerø, Hanne Elisabeth Akselsen, Rune Moe, Heidi Nygård, Ingunn Brandt, Håkon Gjessing, Jennifer Harris, Dag Erik Undlien, Robert Lyle, (2011). Extensive variation and low heritability of DNA methylation identified in a twin study. Genome Research s. 1813-1821. doi: 10.1101/gr.119685.110
- Uppala Ratnamala, Robert Lyle, Rakesh Rawal, Raminder Singh, Satti Vishnupriya, Pamini Himabindu, Vittal Rao, Somesh Aggarwal, Prasuna Paluru, Lucia Bartoloni, Terri L. Young, Ariane Paoloni-Giacobino, Michael A. Morris, Swapan K. Nath, Stylianos E. Antonarakis, Uppala Radhakrishna, (2011). Refinement of the X-linked Nonsyndromic High-Grade Myopia Locus MYP1 on Xq28 and Exclusion of 13 Known Positional Candidate Genes by Direct Sequencing. Investigative Ophthalmology and Visual Science s. 6814-6819. doi: 10.1167/iovs.10-6815
- Martijn Stax, Marloes A Naarding, Michael WT Tank, Susanne Lindquist, Olle Hernell, Robert Lyle, Per Brandtzæg, Merete Åse Eggesbø, Georgios Pollakis, William A Paxton, (2011). Binding of Human Milk to Pathogen Receptor DC-SIGN Varies with Bile Salt-Stimulated Lipase (BSSL) Gene Polymorphism. PLOS ONE doi: 10.1371/journal.pone.0017316
- Monica Cheng Munthe-Kaas, Tale Mæhre Torjussen, Kristina Gervin, Karin C. Lødrup Carlsen, Kai-Håkon Carlsen, Berit Granum, Hanne Sagsveen Hjorthaug, Dag Undlien, Robert Lyle, (2010). CD14 polymorphisms and serum CD14 levels through childhood: A role for gene methylation?. Journal of Allergy and Clinical Immunology s. 1361-1368. doi: 10.1016/j.jaci.2010.02.010
- Robert Lyle, Frédérique Béna, Sarantis Gagos, Corinne Gehrig, G Lopez, Albert Schinzel, James Lespinasse, Armand Bottani, Sophie Dahoun, L. Taine, Martine Doco-Fenzy, Pascale Cornillet-Lefebvre, A Pelet, Stanislas Lyonnet, Annick Toutain, Laurence Colleaux, Jürgen Horst, Ingo Kennerknecht, Nobuaki Wakamatsu, Maria Descartes, Judy C Franklin, Lina Florentin-Arar, Sophia Kitsiou, Emilie Aït Yahya-Graison, Maher Costantine, Pierre-Marie Sinet, Jean M Delabar, Stylianos E. Antonarakis, (2009). Genotype-phenotype correlations in Down syndrome identified by array CGH in 30 cases of partial trisomy and partial monosomy chromosome 21. European Journal of Human Genetics s. 454-466. doi: 10.1038/ejhg.2008.214
- Sina Rostami, Hilde Langseth, robert lyle, Tone Bjørge, Luca Pestarino, Trine Ballestad Rounge, (2022). Pre-diagnostic circulating RNAs in endometrial cancer – impact of body mass index.
- Athina Samara, Martin Falck, Mari Spildrejorde, Magnus Leithaug, Ganesh Acharya, Robert Lyle, Ragnhild Eskeland, (2022). Robust neuronal differentiation of human embryonic stem cells for neurotoxicology. STAR Protocols doi: 10.1016/j.xpro.2022.101533
- Robert Lyle, Hedvig Marie Egeland Nordeng, (2016). Navlestreng-analyser hjelper gravide til tryggere medisinbruk.
- Hedvig Marie Egeland Nordeng, Robert Lyle, Kristina Gervin, (2015). Use of paracetamol during pregnancy: adverse epigenetic side-effects and development of ADHD..
- Hedvig Marie Egeland Nordeng, Robert Lyle, Kristina Gervin, (2015). Medications during pregnancy: effects on neurodevelopmental disorders in childhood and epigenetic outcomes..
- Javier Pena-Diaz, Siv Anita Hegre, Endre Anderssen, Per Arne Aas, Robin Mjelle, Gregor Duncan Gilfillan, Robert Lyle, Finn Drabløs, Hans Einar Krokan, Pål Sætrom, (2013). Transcription profiling during the cell cycle shows that a subset of Polycomb-targeted genes is upregulated during DNA replication.
- Helene Johannessen, David Revesz, Yosuke Kodama, Nikki Cassie, Karolina P. Skibicka, Robert Lyle, Girao Paulo Jorge Bettencourt, Miroljub Popovic, Menno Witter, Perry Barrett, Suzanne L. Dickson, Jens J. Holst, Jens F. Rehfeld, Koji Takeuchi, Bård Kulseng, Thorleif Thorlin, Elinor Ben-Menachem, Chun-Mei Zhao, Duan Chen, (2013). Role of the vagus nerve in the gut-brain axis revealed by stimulation and blockade of the gastric vagus nerve.
- Helene Johannessen, David Revesz, Yosuke Kodama, Nikki Cassie, Karolina P. Skibicka, Robert Lyle, Paulo Bettencourt, Popovic Miroljub, Menno Witter, Perry Barrett, Suzanne L. Dickson, Takeuchi Koji, Bård Kulseng, Thorleif Thorlin, Elinor Ben-Menachem, Chun-Mei Zhao, Duan Chen, (2013). Role of the vagus nerve in the gut-brain axis revealed by stimulation and blockade of the gastric vagus nerve. Gastroenterology
- Helene Johannessen, David Revesz, Yosuke Kodama, Nikki Cassie, Karolina P. Skibicka, Robert Lyle, Paulo Bettencourt, Popovic Miroljub, Menno Witter, Perry Barrett, Suzanne L. Dickson, Takeuchi Koji, Bård Kulseng, Thorleif Thorlin, Elinor Ben-Menachem, Chun-Mei Zhao, Duan Chen, (2013). Role of the vagus nerve in the gut-brain axis revealed by stimulation and blockade of the gastric vagus nerve.
- Asbjørg Stray-Pedersen, Hanne Sørmo Sorte, Olaug Kristin Rødningen, Robert Lyle, C G Gonzaga-Jauregui, C I Hanson, L M Noroski, S. Nicholas, Hans Christian Erichsen, Tore G Abrahamsen, Berit Flatø, Liv T. N. Osnes, Ketil Riddervold Heimdal, Dag Erik Undlien, J.R Lupski, W T Shearer, (2012). THE UTILITY OF EXOME SEQUENCING IN PRIMARY IMMUNODEFICIENCY DISEASES AND IMMUNODYSREGULATIVE DISORDERS. Journal of Clinical Immunology s. 184-185.
- Mina Susanne Weedon-Fekjær, Ying Sheng, Florian Herse, Robert Lyle, Meryam Sugulle, Ralf Dechend, Anne Cathrine Staff, (2012). DIFFERENTIAL EXPRESSION OF MIRNAS IN PLACENTA FROM EARLY AND LATE ONSET PREECLAMPSIA VERSES CONTROLS. Placenta s. A78-A78.
- A. Leidenroth, Hanne Sørmo Sorte, Gregor Duncan Gilfillan, M. Ehrlich, Robert Lyle, J. E. Hewitt, (2012). Diagnosis by sequencing: correction of misdiagnosis from FSHD2 to LGMD2A by whole exome analysis. Neuromuscular Disorders s. S29-S29.
- Jan P Dumanski, LA Forsberg, C Rasi, HR Razzaghian, G Pakalapati, L Waite, KS Thilbeault, A Ronowicz, NE Wineinger, HK Tiwari, D Boomsma, MP Westerman, Jennifer Harris, Robert Lyle, M Essand, F Eriksson, TL Assimes, C Iribarren, E Strachan, TP O'Hanlon, LG Rider, FW Miller, V Giedraitis, L Lannfelt, M Ingelsson, A Piotrowski, NL Pedersen, D Absher, (2012). Age-related accumulation of somatic structural changes in the nuclear genome of human blood cells in vivo. Journal of Medical Genetics s. S42-S42.