Effect of electronic cigarette device properties on the composition of emission
This is a protocol for a systematic review. As part of the collaboration with Joint Action on Tobacco Control 2 (JATC2) we will systematically evaluate the effect of different device properties on the composition of emission.
Electronic cigarettes (e-cigarettes), both with or without nicotine, comes in a wide variety of product types and contents. E-cigarettes consist of a heating element associated with a battery and a cartridge containing a liquid (e-cigarette liquid). E-cigarettes can be disposable, rechargeable with a cartridge, or manually refillable with e-cigarette liquid. When heated, the e-cigarette liquid will form an aerosol (vapour) meant to be inhaled through a mouthpiece. To do an updated risk assessment on the use of e-cigarettes, it is important to map the contributions of the different properties of the e-cigarettes on the formation of different hazardous constituents and their levels in the emission.
As part of the collaboration with Joint Action on Tobacco Control 2 (JATC2) we will systematically evaluate the effect of different device properties on the composition of emission. The evaluation will be based on scientific methods for collection, assessments and summarizing of studies on emissions from e-cigarettes.
We will conduct a systematic search for literature. Titles and abstracts will be considered according to the inclusion and exclusion criteria. References will be screened by two researchers in pairs and independently, first by title and abstract and subsequently in full text, for inclusion and exclusion.
We will assess the risk of bias of the of included studies, conduct meta-analysis if relevant and assess our confidence in the results using the GRADE-approach.