Methods and tools for assessing chemical exposure in humans: protocol for a systematic scoping review
The vision of ONTOX is to provide a functional and sustainable solution for advancing human risk assessment of chemicals without the use of animals in line with the principles of 21st century toxicity testing and next generation risk assessment.
About the project
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Project period: 01.10.2021 - 30.06.2023 (Concluded)
- Coordinating Institution: Norwegian Institute of Public Health
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Project Manager:
- Trine Husøy, Avdeling for mattrygghet, Norwegian Institute of Public Health
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Project Participants:
- Michael Guy Diemar, 3RsMC ApS
- Erwin Roggen, 3RsMC ApS
- Maria Kalyva, Avdeling for kjemikalietoksikologi, Norwegian Institute of Public Health
- Hubert Dirven, Avdeling for kjemikalietoksikologi, Norwegian Institute of Public Health
- Gunn Elisabeth Vist, Reviews and Health Technology Assessments, Norwegian Institute of Public Health
- Project plan: Prosjektplan_Systematiske oversikter_ONTOX_Exposure methods.pdf
Summary
The project ‘Ontology-driven and artificial intelligence-based repeated dose toxicity testing of chemicals for next generation risk assessment’ (ONTOX) under the EU programme Horizon 2020 is running from 01.05.21 to 30.04.26 and is coordinated by Vrije Universiteit, Brussel, Belgium (project website, URL: https://ontox-project.eu/project/).
The vision of ONTOX is to provide a functional and sustainable solution for advancing human risk assessment of chemicals without the use of animals in line with the principles of 21st century toxicity testing and next generation risk assessment. ONTOX will perform exposure assessment on selected chemicals. Preferably existing dietary, dermal and inhalation exposure methods and/or tools will be used. In order to have the best selection of tools available, we will conduct this scoping review to get an overview over publicly available exposure methods/tools.
We will assess the advantages and disadvantages of the different methods that we identify.