Exposure of the father and implications for the child: Analysis of genetic and epigenetic changes in triads-a case-control study
Our ambition is to identify paternal factors of major importance for the health of the child, thereby preventing health risk of new generations.
About the project
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Project period: 10.10.2013 - 01.01.2025 (Active)
- Coordinating Institution: Norwegian Institute of Public Health
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Project Manager:
- Kristine Bjerve Gützkow, Norwegian Institute of Public Health
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Project Participants:
- Kristine Bjerve Gützkow, Infection Control, Norwegian Institute of Public Health
- Roger W.L. Godschalk, Maastricht University
- Andrew Schoenrock, Health Canada
- Andrea Rowan-Carroll, Health Canada
- Francesco Marchetti, Health Canada
- Carole Yauk, Health Canada
- Gunnar Brunborg, Norwegian Institute of Public Health
- Nur Duale, Infection Control, Norwegian Institute of Public Health
- Ann-Karin Hardie Olsen, Infection Control, Norwegian Institute of Public Health
Summary
To test whether paternal tobacco smoking results in an increased incidence of de novo mutations or epigenetic changes in the offspring and to protect the new-born child from disease caused by father's lifestyle. Genetic and epigenetic consequences of paternal environmental exposure will be studied by advanced genetic (next generation sequencing) and epigenetic methods (miRNA and DNA-methylation). We will extend our recent and ground-breaking results from analysis of minisatellite mutations in a small cohort BraMiljø (J. O. Linschooten et al., FASEB J. (2013)), to whole genome sequencing of triads of 20 mothers, fathers (10 smokers + 10 non-smokers) and their children, selected from the MoBa study. Further, the objective is to confirm that mutations from the father due to his smoking are transmitted to the child. From our recent animal in vitro fertilization findings, we will also explore whether epigenetic modifications in the child are associated with father's exposures. Our ambition is to identify paternal factors of major importance for the health of the child, thereby preventing health risk of new generations.