Intrauterine environmental exposures and pregnancy outcomes
Project
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This project will investigate whether various intrauterine environmental factors have a causal effect on pregnancy complications by using genetic markers as instrumental variables.
Summary
This project will investigate whether various intrauterine environmental factors have a causal effect on pregnancy complications by using genetic markers as instrumental variables.
Abstract
Research has shown that lifestyle and environmental factors, such as maternal smoking and BMI during pregnancy, are associated with pregnancy complications. However, it is unclear whether these associations are due to a causal effect of the intrauterine exposures, or whether the associations are due to other background factors that affect both lifestyle and environmental exposures in addition to pregnancy complications. In this project, we will investigate whether various intrauterine environmental factors have a causal effect on pregnancy complications by using genetic markers as instrumental variables. The project will include all participants in the Norwegian Mother and Child Study who have quality-assured GWAS data. GWAS means genome-wide association study, i.e. the use of marker genes throughout the genome. The research will help to increase our understanding of risk factors for common pregnancy complications, which is essential for further preventive forearm health work.
Project leader
Maria Christine Magnus, Norwegian Institute of Public Health
Project participants
Debbie Lawlor, University of Bristol
Per Magnus, Centre for Fertility and Health, Norwegian Institute of Public Health
Ronny Myhre, Genetics and Bioinformatics, Norwegian Institute of Public Health
Jack Bowden, University of Bristol
Qian Yang, University of Bristol
Maria-Carolina Borges, University of Bristol
Fanny Kilpi, University of Bristol
Siri Eldevik Håberg, Centre for Fertility and Health, Norwegian Institute of Public Health
About the project
Start
01.08.2018
End
31.12.2026
Status
Active
Approvals
Regional committees for medical and health research ethics
Project owner/ Project manager
Norwegian Institute of Public Health