Tim Hofer
Researcher ＆ Regulatory advisor
Contact
Send email {model.translations.sendEmailTo} Tim.Hofer@fhi.no
Department
Responsibilities
Human toxicology.
Projects and publications
- Hildegunn Dahl, Ann-Karin Hardie Olsen, Einar Sverre Berg, Nur Duale, Tim Hofer, Anne Graupner, Dag Anders Brede, Dag Markus Eide, (2025). Dose rate-driven responses to ionizing radiation in CBA/Ca and C57BL/6N evaluated using benchmark dose (BMD) modeling. Science of the Total Environment doi: 10.1016/j.scitotenv.2025.179589
- Helle Katrine Knutsen, Agneta Åkesson, Vasileios Bampidis, Laurent Bodin, James Kevin Chipman, Gisela Degen, Antonio Hernández- Jerez, Tim Hofer, Christer Hogstrand, Stefano Landi, Jean-Charles LeBlanc, Kyriaki Machera, Evangelia Ntzani, Guido Rychen, Salomon Sand, Tanja Schwerdtle, Katharina Vejdovszky, Barbara Viviani, Emanuela Corsini, Ludovic Le Hégarat, Hans Steinkellner, Margherita Bignami, (2024). Genotoxicity of beauvericin. EFSA Journal s. 1-23. doi: 10.2903/j.efsa.2024.9031
- Helle Katrine Knutsen, Agneta Åkesson, Vasileios Bampidis, Margherita Bignami, Laurent Bodin, James Kevin Chipman, Gisela Degen, Antonio Hernández- Jerez, Tim Hofer, Stefano Landi, Jean-Charles LeBlanc, Kyriaki Machera, Evangelia Ntzani, Guido Rychen, Salomon Sand, Tanja Schwerdtle, Katharina Vejdovszky, Barbara Viviani, Diane Benford, Andy Hart, Martin Rose, Henri Schroeder, Christiane Vleminckx, Martine Vrijheid, Eleni Gkimprixi, Eirini Kouloura, Francesca Riolo, Luisa Ramos Bordajandi, Christer Hogstrand, (2024). Update of the risk assessment of brominated phenols and their derivatives in food. EFSA Journal s. 1-83. doi: 10.2903/j.efsa.2024.9034
- Helle Katrine Knutsen, Agneta Åkesson, Vasileios Bampidis, Margherita Bignami, Laurent Bodin, James Kevin Chipman, Gisela Degen, Antonio Hernández- Jerez, Tim Hofer, Christer Hogstrand, Stefano Landi, Jean-Charles LeBlanc, Kyriaki Machera, Evangelia Ntzani, Guido Rychen, Salomon Sand, Katharina Vejdovszky, Barbara Viviani, Lars Barregård, Diane Benford, Eugenia Dogliotti, Kevin Francesconi, Jose Ángel Gómez Ruiz, Hans Steinkellner, Tanja Schwerdtle, (2024). Risk assessment of complex organoarsenic species in food. EFSA Journal s. 1-78. doi: 10.2903/j.efsa.2024.9112
- Johanna Eva Bodin, Tim Hofer, Mette Helen Bjørge Müller, Christine Louise Parr, Nana Yaa Boahene, (2024). Risk assessment of hesperidin – “other substances”. VKM Bulletin s. 1-78.
- Petr Dusek, Tim Hofer, Jan Alexander, Per M. Roos, Jan Olav Aaseth, (2022). Cerebral Iron Deposition in Neurodegeneration. Biomolecules doi: 10.3390/biom12050714
- Andrea Capucciati, Fabio A. Zucca, Enrico Monzani, Luigi Zecca, Luigi Casella, Tim Hofer, (2021). Interaction of Neuromelanin with Xenobiotics and Consequences for Neurodegeneration; Promising Experimental Models. Antioxidants doi: 10.3390/antiox10060824
- Tim Hofer, Oddvar Myhre, Johanna Peltola-Thies, Doris Hirmann, (2021). Analysis of elimination half-lives in MamTKDB 1.0 related to bioaccumulation: Requirement of repeated administration and blood plasma values underrepresent tissues. Environment International doi: 10.1016/j.envint.2021.106592
- Birgitte Lindeman, Ylva Johansson, Mathilda Andreassen, Trine Husøy, Hubert Dirven, Tim Hofer, Helle Katrine Knutsen, Ida Henriette Caspersen, Kristine Vejrup, Ragnhild Elisabeth Paulsen, Jan Alexander, Anna Forsby, Oddvar Myhre, (2021). Does the food processing contaminant acrylamide cause developmental neurotoxicity? A review and identification of knowledge gaps. Reproductive Toxicology s. 93-114. doi: 10.1016/j.reprotox.2021.02.006
- Hanne Friis Berntsen, Nur Duale, Cesilie Granum Bjørklund, Oscar Daniel Rangel-Huerta, Kine Dyrberg, Tim Hofer, Kirsten Eline Rakkestad, Gunn Charlotte Østby, Ruth Halsne, Gudrun Seeberg Boge, Ragnhild Elisabeth Paulsen, Oddvar Myhre, Erik Ropstad, (2020). Effects of a human-based mixture of persistent organic pollutants on the in vivo exposed cerebellum and cerebellar neuronal cultures exposed in vitro. Environment International doi: 10.1016/j.envint.2020.106240
- Vicente Mustieles, Shereen Cynthia D'Cruz, Stephan Couderq, Andrea Rodríguez-Carrillo, Jean-Baptiste Fini, Tim Hofer, Inger-Lise Steffensen, Hubert Dirven, Robert Barouki, Nicolás Olea, Mariana F. Fernández, Arthur David, (2020). Bisphenol A and its analogues: A comprehensive review to identify and prioritize effect biomarkers for human biomonitoring. Environment International s. 1-22. doi: 10.1016/j.envint.2020.105811
- Inger-Lise Steffensen, Hubert Dirven, Stephan Couderq, Arthur David, Shereen Cynthia D'Cruz, Mariana F. Fernández, Vicente Mustieles, Andrea Rodríguez-Carrillo, Tim Hofer, (2020). Bisphenols and oxidative stress biomarkers – Associations found in human studies, evaluation of methods used, and strengths and weaknesses of the biomarkers. International Journal of Environmental Research and Public Health (IJERPH) doi: 10.3390/ijerph17103609
- Geir Bjørklund, Tim Hofer, Valeria Marina Nurchi, Jan Aaseth, (2019). Iron and other metals in the pathogenesis of Parkinson's disease: Toxic effects and possible detoxification. Journal of Inorganic Biochemistry doi: 10.1016/j.jinorgbio.2019.110717
- Tim Hofer, Lennart Möller, (2018). Protection of female c3h mice against whole-body -irradiation with 2,3-dimethyl-6-((2-dimeth-ylamino)ETHYL)-6H-indolo[2,3-b]quinoxaline (B220). European Chemical Bulletin (ECB) s. 84-88. doi: 10.17628/ecb.2018.7.84-88
- Yuqing Zhang, Tianyu Dong, Weiyue Hu, Xu Wang, Bo Xu, Zhongning Lin, Tim Hofer, Pawel Stefanoff, Ying Chen, Xinru Wang, Yankai Xia, (2018). Association between exposure to a mixture of phenols, pesticides, and phthalates and obesity: Comparison of three statistical models. Environment International s. 325-336. doi: 10.1016/j.envint.2018.11.076
- Oddvar Myhre, Dag Markus Eide, Synne Kleiven, Hans Christian Utkilen, Tim Hofer, (2018). Repeated five-day administration of L-BMAA, microcystin-LR, or as mixture, in adult C57BL/6 mice - lack of adverse cognitive effects. Scientific Reports doi: 10.1038/s41598-018-20327-y
- Tim Hofer, Nur Duale, Martine Muusse, Dag Markus Eide, Hildegunn Dahl, Fernando Boix, Jannike Mørch Andersen, Ann-Karin Olsen, Oddvar Myhre, (2017). Restoration of Cognitive Performance in Mice Carrying a Deficient Allele of 8-Oxoguanine DNA Glycosylase by X-ray Irradiation. Neurotoxicity research doi: 10.1007/s12640-017-9833-7
- Hanne Friis Berntsen, Cesilie Granum Bjørklund, Jean-Nicolas Audinot, Tim Hofer, Steven Verhaegen, Esther Lentzen, Arno Gutleb, Erik Ropstad, (2017). Time-dependent effects of perfluorinated compounds on viability in cerebellar granule neurons: Dependence on carbon chain length and functional group attached. Neurotoxicology s. 70-83. doi: 10.1016/j.neuro.2017.09.005
- Kristine Bjerve Gutzkow, Nur Duale, Trygve Danielsen, Hans von Stedingk, S Shahzadi, Christine Instanes, Ann-Karin Olsen, Inger-Lise Steffensen, Tim Hofer, M Törnqvist, Gunnar Brunborg, Birgitte Lindeman, (2016). Enhanced susceptibility of obese mice to glycidamide-induced sperm chromatin damage without increased oxidative stress. Andrology s. 1102-1114. doi: 10.1111/andr.12233
- Tim Hofer, George Perry, (2016). Nucleic acid oxidative damage in Alzheimer's disease—explained by the hepcidin-ferroportin neuronal iron overload hypothesis?. Journal of Trace Elements in Medicine and Biology s. 1-9. doi: 10.1016/j.jtemb.2016.06.005
- Nur Duale, Kristine Bjerve Gutzkow, Tim Hofer, Birgitte Lindeman, (2016). Impact of Environmental Pollutants on Placentation. s. 345-359. doi: 10.1201/b19151-29
- Tim Hofer, Trond Ø. Jørgensen, Ragnar Ludvig Olsen, (2014). Comparison of Food antioxidants and Iron Chelators in Two Cellular Free Radical Assays: Strong Protection by Luteolin. Journal of Agricultural and Food Chemistry s. 8402-8410. doi: 10.1021/jf5022779
- Yasser Mahmoud Ali Mohamed, Anders Vik, Tim Hofer, Jeanette hammer Andersen, Trond Vidar Hansen, (2013). Polyunsaturated fatty acid-derived chromones exhibiting potent antioxidant activity. Chemistry and Physics of Lipids s. 41-45. doi: 10.1016/j.chemphyslip.2013.03.003
- Oddvar Myhre, Hans Chr. Utkilen, Nur Duale, Gunnar Brunborg, Tim Hofer, (2013). Metal Dyshomeostasis and Inflammation in Alzheimer's and Parkinson's Diseases: Possible Impact of Environmental Exposures. Oxidative Medicine and Cellular Longevity doi: 10.1155/2013/726954
- Tim Hofer, Tonje Engevik Eriksen, Espen Hansen, Ingrid Varmedal, Ida-Johanne Jensen, Jeanette Hammer-Andersen, Ragnar Ludvig Olsen, (2011). Cellular and chemical assays for discovery of novel antioxidants in marine organisms. doi: 10.1007/978-1-60761-956-7_32
- Tim Hofer, Ragnar Ludvig Olsen, (2010). Cellebasert metode for måling av lipidperoksidasjon og antioksidantaktivitet. Bioingeniøren s. 6-12.
- Dorte Herzke, Tim Hofer, Amrit Kaur Sakhi, (2023). Identification of POP candidates for the Stockholm Convention .
- Tim Hofer, (2023). Oxidative Stress in Human Toxicology.
- Jon Arnot, Barbara Birk, Pippa Curtis-Jackson, Frank A.P.C. Gobas, Kai-Uwe Goss, Maike Habekost, Doris Hirmann, Vincent Bonnomet, Tim Hofer, Sylvia Jacobi, Sophia Krause, Heike Laue, Michel Laurentie, Alberto Martin Aparicio, Morné van der Mescht, Caren Rauert, Gabriele Treu, Aaron Redman, Leslie Saunders, Eric Verbruggen, Frank Wania, Paul Whalley, (2022). Bioaccumulation assessment of air-breathing mammals: a discussion paper.
- Marianne Stenrød, Esther Bloem, Nana Yaa Boahene, Tor Fredrik Holth, Tim Hofer, Mette Helen Bjørge Müller, Elise Rundén-Pran, Christian Vogelsang, (2024). VKM’s methodology document for health and environmental risk assessments for use in the Panel on Plant Protection Products. VKM Bulletin s. 1-106.
- Eliska Kuchovska, Antonio Gamba, Luiz Carlos Maia Ladeira, Bernard Staumont, Raphaëlle Lesage, Inger-Lise Steffensen, Graciela Loopez Soop, Tim Hofer, Oddvar Myhre, Hubert Dirven, Liesbet Geris, Ellen Fritsche, (2022). First steps for creating an ontology for cognitive function defects for regulatory application.
- Tim Hofer, (2022). Xenobiotic-neuromelanin interactions and models to study toxicity.
- Tim Hofer, (2021). Oxidative stress in human toxicology. Antioxidants doi: 10.3390/antiox10081159
- Tim Hofer, (2019). Chemical exposure induced neurodegenerative diseases – two recent hypotheses involving metals.
- Hildegunn Dahl, Ann-Karin Hardie Olsen, Dag Markus Eide, Richard Aubrey White, Anne Graupner, Oddvar Myhre, Tim Hofer, Nur Duale, Gunnar Brunborg, Christine Instanes, (2018). A transgenerational study in mice: Chronic low grade pre-conceptional oxidative stress in grandfathers and the susceptibility of grandsons. .
- Tim Hofer, Oddvar Myhre, Doris Hirmann, Sjur Andersen, Tiina A Lantto, Johanna Peltola-Thies, (2018). Bioaccumulation potential in air breathing terrestrial animals – xenobiotic elimination half-life correlations among rat tissues.
- Tim Hofer, Inger-Lise Steffensen, Hubert Dirven, (2018). Bisphenols and oxidative stress effect biomarkers.
- Tim Hofer, (2017). X-ray irradiation (0.5 Gy) leading to restoration of cognitive performance in Ogg1 deficient mice.
- Tim Hofer, Oddvar Myhre, (2017). Use of mammalian toxicokinetic data in bioaccumulation assessment of air-breathing organisms.
- Tim Hofer, (2017). Effects of a mixture of two cyanobacterial toxins (microcystin-LR and L-BMAA) on spatial learning and memory in adult C57BL/6 mice.
- Tim Hofer, (2017). Restoration of cognitive performance in mice carrying a deficient allele of 8-oxoGuanine DNA glycosylase by X-ray irradiation.
- Ann-Karin Olsen, Anne Graupner, Dag Markus Eide, Christine Instanes, Hildegunn Dahl, Jill Mari Andersen, Richard W. Doughty, Birgitte Lindeman, Tim Hofer, Dag Anders Brede, Brit Salbu, Deborah Oughton, Nur Duale, (2016). Reproductive effects of chronic low dose-rate gamma radiation in male mice; role of transcriptional and epigenetic regulation in male germ cells.
- Johanna Peltola Thies, Tiina A Lantto, Silvia Lapenna, Gesine Muller, Zuzana Kloslova, Jane Caley, Sjur Andersen, Marius Gudbrandsen, Tim Hofer, Oddvar Myhre, Eric Verbruggen, Peter Lepper, (2016). Use of toxicokinetic data in bioaccumulation assessment. Toxicology Letters doi: 10.1016/j.toxlet.2016.06.1813
- Oddvar Myhre, Dag Markus Eide, Hans Chr. Utkilen, Tim Hofer, (2016). Effects of a mixture of two cyanobacterials toxins (microcystin-LR and L-BMAA) on spatial learning and memory in adult C57BL/6 mice. Toxicology Letters doi: 10.1016/j.toxlet.2016.06.2087
- Ann-Karin Olsen, Anne Graupner, Jill Mari Andersen, Richard W. Doughty, Birgitte Lindeman, Tim Hofer, Dag Markus Eide, Dag Anders Brede, Deborah Helen Oughton, Brit Salbu, Gunnar Brunborg, Christine Instanes, (2015). Low dose rate gamma irradioation in combination With low Selenium diet - effects on reproduction in male mice.
- Ann-Karin Olsen, Anne Graupner, Jill Mari Andersen, Richard W. Doughty, Birgitte Lindeman, Tim Hofer, Dag Markus Eide, (2015). Low dose rate gamma irradiation in combination with Selenium deficiency - effects on reproduction in male mice.
- Ann-Karin Olsen, Anne Graupner, Dag Markus Eide, Hildegunn Dahl, Jill Mari Andersen, Richard W. Doughty, Birgitte Lindeman, Tim Hofer, Dag Anders Brede, Deborah Helen Oughton, Brit Salbu, Gunnar Brunborg, Christine Instanes, (2015). Low dose rate gamma irradiation in combination with Selenium deficiency – effects on reproduction in male mice .
- Tim Hofer, (2015). Metal dysregulation and oxidative damage in neurodegeneration.
- Trygve Danielsen, Birgitte Lindeman, Tim Hofer, (2015). Analyse av proteinskader forårsaket av oksidativt stress. Toksikologen s. 14-19.
- Tim Hofer, Trond Ø. Jørgensen, Ragnar Ludvig Olsen, (2014). Antioxidant protection from intracellular free radicals and lipid peroxidation in two microplate format cellular assays.
- Tien-Sheng Huang, Hans Christian Eilertsen, Ragnar Ludvig Olsen, Tim Hofer, Trond Ø. Jørgensen, (2013). Antioxidant property of the Arctic microalgae Attheya longicornis and Pyramimoras sp. upon abiotic stress from metal and UV radiation.
- Tim Hofer, Ragnar Ludvig Olsen, (2010). A cellular lipidperoxidation antioxidant activity assay.
- Tim Hofer, TE Eriksen, Ida-Johanne Jensen, Edel Oddny Elvevoll, Trond Ø. Jørgensen, Jeanette hammer Andersen, Ragnar Ludvig Olsen, (2009). Screening for antioxidants in Arctic marine organisms. Free radical research s. 75-75.
- Tim Hofer, (2009). Testing and screening for antioxidants using cell-based ree radical assays.
- Tim Hofer, TE Eriksen, Ida-Johanne Jensen, Edel Oddny Elvevoll, Trond Ø. Jørgensen, Jeanette hammer Andersen, Ragnar Ludvig Olsen, (2009). Screening for antioxidants in Arctic marine organisms.
- Tim Hofer, TE Eriksen, Ida-Johanne Jensen, Edel Oddny Elvevoll, Jeanette hammer Andersen, Ragnar Ludvig Olsen, (2009). Screening for Compounds with Antioxidant Activities from Arctic and sub-Arctic Marine Organisms.
- Tim Hofer, (2009). Effects of antioxidants and metal chelators in cell-based free radical assays.
- Tim Hofer, Tonje Engevik Eriksen, Jeanette hammer Andersen, Ragnar Ludvig Olsen, (2008). Screening for compounds from Arctic and sub-Arctic marine invertebrates with antioxidant activities.