Birgitte Lindeman
Senior Scientist
Contact
Send email {model.translations.sendEmailTo} Birgitte.Lindeman@fhi.no
Department
Responsibilities
Human toxicology
Projects and publications
- Humblenoble Stembridge Ayuk, Arkadiusz Pierzchalski, Tamara Tal, Oddvar Myhre, Birgitte Lindeman, Nicola Margareta Smith, Violeta Stojanovska, Ana Claudia Zenclussen, (2025). Evaluating PFAS-Induced modulation of peripheral blood mononuclear cells (PBMCs) immune response to SARS-CoV-2 spike in COVID-19 Vaccinees. Environment International doi: 10.1016/j.envint.2025.109409
- Elena Salamanca-Fernández, Lydia Espín-Moreno, Alicia Olivas-Martínez, Ainhoa Pérez-Cantero, José L. Martín-Rodríguez, Rafael M. Poyatos, Fabio Barbone, Valentina Rosolen, Marika Mariuz, Luca Ronfani, Ľubica Palkovičová Murínová, Lucia Fábelová, Tamás Szigeti, Réka Kakucs, Amrit Kaur Sakhi, Line Småstuen Haug, Birgitte Lindeman, Janja Snoj Tratnik, Tina Kosjek, Griet Jacobs, Stefan Voorspoels, Helena Jurdáková, Renáta Górová, Ida Petrovičová, Branislav Kolena, Marta Esteban, Susana Pedraza-Díaz, Marike Kolossa-Gehring, Sylvie Remy, Eva Govarts, Greet Schoeters, Mariana F. Fernández, Vicente Mustieles, (2024). Associations between Urinary Phthalate Metabolites with BDNF and Behavioral Function among European Children from Five HBM4EU Aligned Studies. Toxics doi: 10.3390/toxics12090642
- Amanda R. Tursi, Birgitte Lindeman, Anja Bråthen Kristoffersen, Hege Hjertholm, Eugenia Igorjevna Nasonova Leg Bronder, Monica Andreassen, Trine Husøy, Hubert Dirven, Sandra Andorf, Unni Cecilie Nygaard, (2024). Immune cell profiles associated with human exposure to perfluorinated compounds (PFAS) suggest changes in natural killer, T helper, and T cytotoxic cell subpopulations. Environmental Research doi: 10.1016/j.envres.2024.119221
- Anouk Verhoeven, Jonas van Ertvelde, Joost Boeckmans, Alexandra Gatzios, Ramiro Jover, Birgitte Lindeman, Graciela Lopez Soop, Robim M. Rodrigues, Anna Rapisarda, Julen Sanz-Serrano, Marth Stinckens, Sara Sepehri, Marc Teunis, Mathieu Vinken, Jian Jiang, Tamara Vanhaecke, (2024). A quantitative weight-of-evidence method for confidence assessment of adverse outcome pathway networks: A case study on chemical-induced liver steatosis. Toxicology doi: 10.1016/j.tox.2024.153814
- Igor Snapkov, Nicola Margareta Smith, Emma Arnesdotter, Karsten Beekmann, Etienne B. Blanc, Albert Braeuning, Emanuela Corsini, Marija Sollner Dolenc, Loes P.M. Duivenvoorde, Gunnar Sundstøl Eriksen, Nina Franko, Valentina Galbiati, Johanna M. Gostner, Nathalie Grova, Arno C. Gutleb, Rita Hargitai, Aafke Janssen, Solveig Krapf, Birgitte Lindeman, Katalin Lumniczky, Ambra Maddalon, Steen Kristen Mollerup, Lucia Parrakova, Arkadiusz Pierzchalski, Raymond H. H. Pieters, Maria J. Silva, Anita Solhaug, Yvonne Staal, Anne Straumfors, Tünde Szatmári, Jonathan David Turner, Rob J. Vandebriel, Ana Claudia Zenclussen, Robert Barouki, (2024). New approach methodologies to enhance human health risk assessment of immunotoxic properties of chemicals — a PARC (Partnership for the Assessment of Risk from Chemicals) project. Frontiers in Toxicology doi: 10.3389/ftox.2024.1339104
- Thomas Jaylet, Thibaut Coustillet, Nicola Margareta Smith, Barbara Viviani, Birgitte Lindeman, Lucia Vergauwen, Oddvar Myhre, Nurettin Yarar, Johanna Gostner, Pablo Monfort-Lanzas, Florence Jornod, Henrik Holbech, Xavier Coumoul, Dimosthenis A. Sarigiannis, Philipp Antczak, Anna Bal-Price, Ellen Fritsche, Eliska Kuchovska, Antonios Stratidakis, Robert Barouki, Min Ji Kim, Olivier Taboureau, Marcin Wlodzimierz Wojewodzic, Dries Knapen, Karine Audouze, (2024). Comprehensive mapping of the AOP-Wiki database: identifying biological and disease gaps. Frontiers in Toxicology doi: 10.3389/ftox.2024.1285768
- Trine Husøy, Ida Henriette Caspersen, E. Thépaut, Helle Katrine Knutsen, Line Småstuen Haug, Monica Andreassen, Athanasios Gkrillas, Birgitte Lindeman, Cathrine Thomsen, Dorte Herzke, Hubert Dirven, Marcin Wlodzimierz Wojewodzic, (2023). Comparison of aggregated exposure to perfluorooctanoic acid (PFOA) from diet and personal care products with concentrations in blood using a PBPK model – Results from the Norwegian biomonitoring study in EuroMix. Environmental Research s. 1-12. doi: 10.1016/j.envres.2023.117341
- Andrea Rodríguez-Carrillo, Vicente Mustieles, Elena Salamanca-Fernández, Alicia Olivas-Martínez, Beatriz Suárez, Lola Bajard, Kirsten Baken, Ludek Blaha, Eva Cecilie Bonefeld-Jørgensen, Stephan Couderq, Shereen Cynthia D'Cruz, Jean-Baptiste Fini, Eva Govarts, Claudia Gundacker, Antonio F. Hernández, Marina Lacasaña, Federica Laguzzi, Birgitte Lindeman, Manhai Long, Henriqueta Louro, Christiana Neophytou, Axel Oberemn, Sylvie Remy, Anna Kjerstine Rosenmai, Anne Thoustrup Saber, Greet Schoeters, Maria Joao Silva, Fatima Smagulova, Maria Uhl, Anne Marie Vinggaard, Ulla Vogel, Maria Wielsøe, Nicolás Olea, Mariana F. Fernández, (2023). Implementation of effect biomarkers in human biomonitoring studies: A systematic approach synergizing toxicological and epidemiological knowledge. International Journal of Hygiene and Environmental Health s. 1-11. doi: 10.1016/j.ijheh.2023.114140
- Graciela López Soop, Trine Husøy, Marcin Wlodzimierz Wojewodzic, Hege Hjertholm, Anastasia Spyropoulou, Effrosyni S. Katsanou, Petros Batakis, Katerina Kyriakopoulou, Kyriaki Machera, Hubert Dirven, Birgitte Lindeman, Nur Duale, (2023). Transcriptional analysis in peripheral blood cells of individuals with elevated phthalate exposure – Results of the EuroMix study. Environmental Research s. 1-12. doi: 10.1016/j.envres.2023.115377
- Veronika Ehrlich, Wieneke Bil, Rob Vandebriel, Berit Brunstad Granum, Mirjam Luijten, Birgitte Lindeman, Philippe Grandjean, Andreas-Marius Kaiser, Ingrid Hauzenberger, Christina Hartmann, Claudia Gundacker, Maria Uhl, (2023). Consideration of pathways for immunotoxicity of per- and polyfluoroalkyl substances (PFAS). Environmental health s. 1-47. doi: 10.1186/s12940-022-00958-5
- Eleni Zoumpoulia Papadopoulou, Alina Nicolescu, Line Småstuen Haug, Trine Husøy, Calin Delenau, Hubert Dirven, Birgitte Lindeman, (2022). Lipoprotein profiles associated with exposure to poly- and perfluoroalkyl substances (PFASs) in the EuroMix human biomonitoring study. Environmental Pollution s. 1-12. doi: 10.1016/j.envpol.2022.119664
- Steven Ronsmans, Karin Sørig Hougaard, Tim S. Nawrot, Michelle Plusquin, François Huaux, María Jesús Cruz, Horatiu Moldovan, Steven Verpaele, Murali Jayapala, Michael Tunney, Stephanie Humblet-Baron, Hubert Dirven, Unni Cecilie Nygaard, Birgitte Lindeman, Nur Duale, Adrian Liston, Esben Meulengracht Flachs, Kenneth Kastaniegaard, Matthias Ketzel, Julia Goetz, Jeroen Vanoirbeek, Manosij Ghosh, Peter H. M. Hoet, (2022). The EXIMIOUS project-Mapping exposure-induced immune effects: Connecting the exposome and the immunome. Environmental Epidemiology doi: 10.1097/EE9.0000000000000193
- Styliani Fragki, Hubert Dirven, Tony Fletcher, Bettina Grasl‐Kraupp, Kristine Bjerve Gützkow, Ron Hoogenboom, Sander Kersten, Birgitte Lindeman, Jochem Louisse, Ad Peijnenburg, Aldert H. Piersma, Hans M. G. Princen, Maria Uhl, Joost Westerhout, Marco J. Zeilmaker, Mirjam Luijten, (2021). Systemic PFOS and PFOA exposure and disturbed lipid homeostasis in humans: what do we know and what not?. Critical Reviews in Toxicology s. 141-164. doi: 10.1080/10408444.2021.1888073
- Birgitte Lindeman, Ylva Johansson, Mathilda Andreassen, Trine Husøy, Hubert Dirven, Tim Hofer, Helle Katrine Knutsen, Ida Henriette Caspersen, Kristine Vejrup, Ragnhild Elisabeth Paulsen, Jan Alexander, Anna Forsby, Oddvar Myhre, (2021). Does the food processing contaminant acrylamide cause developmental neurotoxicity? A review and identification of knowledge gaps. Reproductive Toxicology s. 93-114. doi: 10.1016/j.reprotox.2021.02.006
- E. Thépaut, Hubert Dirven, Line Småstuen Haug, Birgitte Lindeman, Somrutai Poothong, Monica Andreassen, Hege Hjertholm, Trine Husøy, (2021). Per- and polyfluoroalkyl substances in serum and associations with food consumption and use of personal care products in the Norwegian biomonitoring study from the EU project EuroMix . Environmental Research doi: 10.1016/j.envres.2021.110795
- Birgitte Lindeman, Vera Ritz, (2020). Regulation and Risk Management of Endocrine Disruptors: Current Status and Future Perspectives. s. 495-511. doi: 10.1039/9781839160738-00495
- Jorid B. Sørli, Marit Låg, Leni Johanne Ekeren, Jesus Perez-Gil, Line Småstuen Haug, Emilie Da Silva, Muhammad N. Matrod, Kristine Bjerve Gutzkow, Birgitte Lindeman, (2019). Per- and polyfluoroalkyl substances (PFASs) modify lung surfactant functionand pro-inflammatory responses in human bronchial epithelial cells. Toxicology in Vitro doi: 10.1016/j.tiv.2019.104656
- Nur Duale, Oliwia Witczak, Gunnar Brunborg, Trine B. Haugen, Birgitte Lindeman, (2017). Sperm Epigenome in Obesity. doi: 10.1007/978-3-319-31143-2_53-1
- Abdolrahman Khezri, Birgitte Lindeman, Anette Kristine Krogenæs, Hanne Friis Berntsen, Karin Elisabeth Zimmer, Erik Ropstad, (2017). Maternal exposure to a mixture of persistent organic pollutants (POPs) affects testis histology, epididymal sperm count and induces sperm DNA fragmentation in mice. Toxicology and Applied Pharmacology s. 301-308. doi: 10.1016/j.taap.2017.06.019
- Kristine Bjerve Gutzkow, Nur Duale, Trygve Danielsen, Hans von Stedingk, S Shahzadi, Christine Instanes, Ann-Karin Olsen, Inger-Lise Steffensen, Tim Hofer, M Törnqvist, Gunnar Brunborg, Birgitte Lindeman, (2016). Enhanced susceptibility of obese mice to glycidamide-induced sperm chromatin damage without increased oxidative stress. Andrology s. 1102-1114. doi: 10.1111/andr.12233
- Nana Yaa Ohene Asare, Nur Duale, Hege Holte Slagsvold, Birgitte Lindeman, Ann-Karin Olsen, Joanna Gromadzka-Ostrowska, Sylwia Meczynska-Wielgosz, Marcin Kruszewski, Gunnar Brunborg, Christine Instanes, (2016). Genotoxicity and gene expression modulation of silver and titanium dioxide nanoparticles in mice. Nanotoxicology s. 312-321. doi: 10.3109/17435390.2015.1071443
- Nur Duale, Kristine Bjerve Gutzkow, Tim Hofer, Birgitte Lindeman, (2016). Impact of Environmental Pollutants on Placentation. s. 345-359. doi: 10.1201/b19151-29
- Anne Graupner, Christine Instanes, Stephen D Dertinger, Jill Mari Andersen, Birgitte Lindeman, TD Rongved, Gunnar Brunborg, Ann-Karin Hardie Olsen, (2014). Single cell electrophoresis (SCGE) and Pig-a mutation assay in vivo-tools for genotoxicity testing from a regulatory perspective: a study of benzo[a]pyrene in Ogg1-/- mice. Mutation Research. Genetic Toxicology and Environmental Mutagenesis s. 34-41. doi: 10.1016/j.mrgentox.2014.07.010
- Nur Duale, Inger-Lise Steffensen, Jill Mari Andersen, Asgeir Brevik, Gunnar Brunborg, Birgitte Lindeman, (2014). Impaired sperm chromatin integrity in obese mice. Andrology s. 234-243. doi: 10.1111/j.2047-2927.2013.00178.x
- Asgeir Brevik, Birgitte Lindeman, Vendula Rusnakova, Ann-Karin Hardie Olsen, Gunnar Brunborg, Nur Duale, (2012). Paternal Benzo[a]pyrene Exposure Affects Gene Expression in the Early Developing Mouse Embryo. Toxicological Sciences s. 157-165. doi: 10.1093/toxsci/kfs187
- Asgeir Brevik, Birgitte Lindeman, Gunnar Brunborg, Nur Duale, (2012). Paternal benzo[a]pyrene exposure modulates microRNA expression patterns in the developing mouse embryo. International Journal of Cell Biology doi: 10.1155/2012/407431
- Birgitte Lindeman, Christina Maass, Nur Duale, Kristine Bjerve Gutzkow, Gunnar Brunborg, Åshild Kristine Andreassen, (2012). Effects of per- and polyfluorinated compounds on adult rat testicular cells following in vitro exposure. Reproductive Toxicology s. 531-537. doi: 10.1016/j.reprotox.2011.04.001
- Asgeir Brevik, Vendula Rusnakova, Nur Duale, Hege Holte Slagsvold, Ann-Karin Hardie Olsen, Eleftheria (Ritsa) T. Storeng, Mikael Kubista, Gunnar Brunborg, Birgitte Lindeman, (2011). Preconceptional paternal glycidamide exposure affects embryonic gene expression: Single embryo gene expression study following in vitro fertilization. Reproductive Toxicology s. 463-471. doi: 10.1016/j.reprotox.2011.09.005
- Birgitte Lindeman, (2009). Norway. s. 1051-1060.
- L Wierød, CM Rosseland, Birgitte Lindeman, Morten Pedersen Oksvold, H Grøsvik, E Skarpen, Henrik Huitfeldt, (2008). Activation of the p53-p21(Cip1) pathway is required for CDK2 activation and S-phase entry in primary rat hepatocytes. Oncogene s. 2763-2771. doi: 10.1038/sj.onc.1210937
- Nur Duale, Birgitte Lindeman, Mitsuko Komada, Ann-Karin Hardie Olsen, Åshild Kristine Andreassen, Erik Johan Søderlund, Gunnar Brunborg, (2007). Molecular portrait of cisplatin induced response in human testis cancer cell lines based on gene expression profiles. Molecular Cancer doi: 10.1186/1476-4598-6-53
- L Wierød, CM Rosseland, Birgitte Lindeman, MP Oksvold, H Grøsvik, E Skarpen, HS Huitfeldt, (2007). CDK2 regulation through P13K and CDK4 is necessary for cell cycle progression of primary rat hepatocytes. Cell Proliferation s. 475-487. doi: 10.1111/j.1365-2184.2007.00451.x
- Ann-Karin Olsen, Birgitte Lindeman, Richard Wiger, Nur Duale, Gunnar Brunborg, (2005). How do male germ cells handle DNA damage?. Toxicology and Applied Pharmacology s. S521-S531. doi: 10.1016/j.taap.2005.01.060
- Camilla Svendsen, Marit Låg, Birgitte Lindeman, Monica Andreassen, Berit Brunstad Granum, (2024). New knowledge on health effects of amines and their derivatives associated with CO2 capture.
- Ragna Bogen Hetland, Line Småstuen Haug, Kristine Bjerve Gutzkow, Birgitte Lindeman, Rune Becher, (2017). Innånding av støvpartikler ved bruk av fluorholdige skismøringsprodukter. Eksponeringsnivåer for ikke-profesjonelle skismørere – en pilotstudie .
- Ragna Bogen Hetland, Gunnar Brunborg, Hubert Dirven, Nina Gjølme, Christine Instanes, Birgitte Lindeman, (2014). Inntak av plantevernmidler gjennom drikkevann vurdert i forhold til vedtatte grenseverdier - Rapport til prosjektet "Kartlegging av helseskader fra plantevernmidler - 2014".
- Karina Petersen, Birgitte Lindeman, (2014). Road to regulation of endocrine disruptors and combination effects.
- Marit Låg, Birgitte Lindeman, Christine Instanes, Gunnar Brunborg, Per E Schwarze, (2011). Health effects of amines and derivatives associated with C02 capture.
- Marit Låg, Birgitte Lindeman, Christine Instanes, Gunnar Brunborg, Per Everhard Schwarze, (2011). Health effects of amines and derivatives associated with CO2 capture .
- Marit Låg, Åshild Kristine Andreassen, Christine Instanes, Birgitte Lindeman, (2009). Health effects of different amines and possible degradation products relevant for CO2 capture.
- M Morreno Torres, E Lopez Pascual, AS Rapisarda, M Moreno, G Lopez, T Jr Bozada, J Jiang, J Van Ertvelde, Inger-Lise Steffensen, Birgitte Lindeman, Thomas Luechtefeld, Hubert Dirven, Mathieu Vinken, Ramiro Jover, (2023). Novel clinical phenotypes and chemical classifications in drug-induced cholestasis: analysis of a database of 390 patients developed by collaborative literature review and machine learning support.
- Ann-Karin Hardie Olsen, Hildegunn Dahl, Torstein Tengs, Dag Markus Eide, Nur Duale, Birgitte Lindeman, (2022). Genotoxic and transcriptional responses to combined exposures to arsenic and ionizing radiation in mouse liver.
- Birgitte Lindeman, Edel Marie Lilleaas, Marit Låg, Ann-Karin Hardie Olsen, Kristine Bjerve Gutzkow, (2018). Adaptations of the comet assay for genotoxicity testing using metabolically active human liver spheroids. .
- Kristine Bjerve Gutzkow, Marit Låg, Edel Marie Lilleaas, Birgitte Lindeman, (2017). Bruk av 3D leverkulturer for å måle DNA-skade ved komet-metoden.
- Kristine Bjerve Gutzkow, Edel Marie Lilleaas, Marit Låg, Ann-Karin Olsen, Birgitte Lindeman, (2017). Establishment of genotoxicity testing using the Comet assay of metabolically active 3D liver spheroid cultures.
- Kristine Bjerve Gutzkow, Edel Marie Lilleaas, Marit Låg, Ann-Karin Olsen, Birgitte Lindeman, (2017). Establishment of genotoxicity testing using teh comet assay of metabolically active 3D liver spheroids cultures using X-rays and Arsenic trioxide.
- Mateusz Wilks, Bas J. Blaauboer, Rolf Schulte-Herman, H Wallace, CL Galli, Marie Haag-Grönlund, Vesna Matovic, João Paulo Teixeira, Johanna Zilliacus, Nursen Basaran, Eva Cecilie Bonefeld-Jørgensen, Philippe Bourrinet, Werner Brueller, Nancy Claude, Joana P. Miranda, Ursula Gundert-Remy, Helen Håkansson, Leda Kovatsi, Jyrki Liesivuori, Birgitte Lindeman, Dominique Lison, Isabelle Leconte, Emma Martínez-López, Marek Murias, Cecile Michel, Paul T.J. Scheepers, Lesley Stanley, Aristidis Tsatsakis, (2016). The European Registered Toxicologist (ERT): Current status and prospects for advancement. Toxicology Letters s. 151-155. doi: 10.1016/j.toxlet.2016.06.014
- Ann-Karin Olsen, Anne Graupner, Dag Markus Eide, Christine Instanes, Hildegunn Dahl, Jill Mari Andersen, Richard W. Doughty, Birgitte Lindeman, Tim Hofer, Dag Anders Brede, Brit Salbu, Deborah Oughton, Nur Duale, (2016). Reproductive effects of chronic low dose-rate gamma radiation in male mice; role of transcriptional and epigenetic regulation in male germ cells.
- Nur Duale, Ana Maria Mihaela Stoian, Inger-Lise Steffensen, Birgitte Lindeman, (2016). Developmental exposure to high-fat diet has a long term impact on adipose tissue microRNA expression in mice.
- Ann-Karin Olsen, Anne Graupner, Jill Mari Andersen, Richard W. Doughty, Birgitte Lindeman, Tim Hofer, Dag Markus Eide, Dag Anders Brede, Deborah Helen Oughton, Brit Salbu, Gunnar Brunborg, Christine Instanes, (2015). Low dose rate gamma irradioation in combination With low Selenium diet - effects on reproduction in male mice.
- Ann-Karin Olsen, N.M. Duale, Dag Markus Eide, Sergey Shaposhikov, Anne Graupner, Birgitte Lindeman, Christine Instanes, Gunnar Brunborg, (2015). DNA methylation in spermatozoa of mice after chronic exposure to continuous low dose rate gamma irradiation and Selenium deficiency.
- Ann-Karin Olsen, Anne Graupner, Jill Mari Andersen, Richard W. Doughty, Birgitte Lindeman, Tim Hofer, Dag Markus Eide, (2015). Low dose rate gamma irradiation in combination with Selenium deficiency - effects on reproduction in male mice.
- Ann-Karin Olsen, Dag Markus Eide, Anne Graupner, Birgitte Lindeman, Christine Instanes, Deborah Helen Oughton, Brit Salbu, Gunnar Brunborg, Nur Duale, (2015). DNA methylation in spermatozoa of mice after chronic exposure to continuous low dose rate gamma irradiation and Selenium deficiency .
- Ann-Karin Olsen, Anne Graupner, Dag Markus Eide, Hildegunn Dahl, Jill Mari Andersen, Richard W. Doughty, Birgitte Lindeman, Tim Hofer, Dag Anders Brede, Deborah Helen Oughton, Brit Salbu, Gunnar Brunborg, Christine Instanes, (2015). Low dose rate gamma irradiation in combination with Selenium deficiency – effects on reproduction in male mice .
- Trygve Danielsen, Birgitte Lindeman, Tim Hofer, (2015). Analyse av proteinskader forårsaket av oksidativt stress. Toksikologen s. 14-19.
- Julie Håland, A Olsen, B Lindeman, Å Andreassen, R Wiger, N Duale, E Søderlund, Jørgen Stenersen, E Brunborg, (2005). Repair of oxidative DNA lesions in mOGG1 knock-out mice.