Fagområder
Genetic epidemiology, population genetics, quantitative genetics, statistical genetics, psychiatric genetics
Faglig bakgrunn
My research focuses on investigating the causes, development, and consequences of sleep problems and fatigue, using a variety of statistical genetic approaches in genome-wide data sets. This research builds on the knowledge and techniques I learnt throughout my postdoctoral research investigating the genetics of ADHD and OCD traits with cognitive deficits and PhD research characterising the relationship between fatigue and depression. The statistical techniques I have used include, twin modelling, SNP-based heritability and genetic correlation analyses, genome-wide association (GWA) analyses, gene-based association analyses, multivariate GWA analyses, and pleiotrophy analyses. While both these projects involved the use of microarray genotyping data, my Honours project enabled me to learn how to analyse next-generation sequencing data, through the investigation of microevolution between two serial clinical isolates of an opportunistic human fungal pathogen.
Additionally, I have led the effort to develop and implement a pre-imputation quality control (QC), phasing, imputation, and post-imputation QC pipeline of the Norwegian Mother, Father, and Child cohort study (MoBa). The effort was undertaken to align with current QC protocols in human genetics, account for the complex family structure in MoBa (following the Picopili family-based pipeline), and meet the standards of international consortia.
Prosjekter og publikasjoner
- Jean-Baptiste Pingault, Wikus Barkhuizen, Biyao Wang, Laurie John Hannigan, Espen Moen Eilertsen, Elizabeth Claire Corfield, Ole Andreassen, Helga Ask, Martin Steen Tesli, Ragna Bugge Askeland, George Davey Smith, Camilla Stoltenberg, Neil Martin Davies, Ted Reichborn-Kjennerud, Eivind Ystrøm, Alexandra Havdahl, (2022). Genetic nurture versus genetic transmission of risk for ADHD traits in the Norwegian Mother, Father and Child Cohort Study. Molecular Psychiatry doi: 10.1038/s41380-022-01863-6
- Alexandra Havdahl, Robyn E Wootton, Beate Leppert, Lucy Riglin, Helga Ask, Martin Steen Tesli, Ragna Bugge Askeland, Laurie John Hannigan, Elizabeth Claire Corfield, Anne-Siri Øyen, Ole Andreassen, Kate Tilling, George Davey Smith, Anita Thapar, Ted Reichborn-Kjennerud, Evie Stergiakouli, (2022). Associations between Pregnancy-Related Predisposing Factors for Offspring Neurodevelopmental Conditions and Parental Genetic Liability to Attention-Deficit/Hyperactivity Disorder, Autism, and Schizophrenia: The Norwegian Mother, Father and Child Cohort Study (MoBa). JAMA psychiatry s. 799-810. doi: 10.1001/jamapsychiatry.2022.1728
- Christie L. Burton, Mathieu Lemire, Bowei Xiao, Elizabeth Claire Corfield, Lauren Erdman, Janita Bralten, Geert Poelmans, Dongmei Yu, S-M Shaheen, Tara Goodale, Vanessa M. Sinopoli, Noam Soreni, Gregory L. Hanna, Kate D. Fitzgerald, David Rosenberg, Gerald Nestadt, Andrew D. Paterson, Lisa J. Strug, Russell J. Schachar, Jennifer Crosbie, Paul D. Arnold, (2021). Genome-wide association study of pediatric obsessive-compulsive traits: Shared genetic risk between traits and disorder. Translational Psychiatry doi: 10.1038/s41398-020-01121-9
- Ditte Demontis, Raymond K Walters, Veera M. Rajagopal, Irwin D. Waldman, Jakob Grove, Tomas D. Als, Søren Dalsgaard, Marta Ribasés, Johnas Bybjerg-Grauholm, Maria Bækvad-Hansen, Tomas Werge, Merete Nordentoft, Ole Andreassen, Elizabeth Claire Corfield, Alexandra Havdahl, Bru Cormand, David M. Hougaard, Benjamin M. Neale, Barbara Franke, Stephen V. Faraone, Anders D. Børglum, (2021). Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder. Nature Communications doi: 10.1038/s41467-020-20443-2
- Ragna Bugge Askeland, Laurie J. Hannigan, Helga Ask, Ziada Ayorech, Martin Steen Tesli, Elizabeth Corfield, Per Minor Magnus, Pål Rasmus Njølstad, Ole A. Andreassen, George Davey Smith, Ted Reichborn-Kjennerud, Alexandra Havdahl, (2021). Early manifestations of genetic risk for neurodevelopmental disorders. Journal of Child Psychology and Psychiatry s. 1-10. doi: 10.1111/jcpp.13528
- Laurie John Hannigan, Ragna Bugge Askeland, Helga Ask, Martin Tesli, Elizabeth Corfield, Ziada Ayorech, Øyvind Helgeland, Per Magnus, Pål Rasmus Njølstad, Anne-Siri Øyen, Camilla Stoltenberg, Ole A. Andreassen, George Davey Smith, Ted Reichborn-Kjennerud, Alexandra Havdahl, (2021). Genetic Liability for Schizophrenia and Childhood Psychopathology in the General Population. Schizophrenia Bulletin s. 1179-1189. doi: 10.1093/schbul/sbaa193
- Christie L. Burton, Leah Wright, Janet Shan, Bowei Xiao, Annie Dupuis, Tara Goodale, S-M Shaheen, Elizabeth Claire Corfield, Paul D. Arnold, Russell J. Schachar, Jennifer Crosbie, (2019). SWAN scale for ADHD trait-based genetic research: A validity and polygenic risk study. Journal of Child Psychology and Psychiatry doi: 10.1111/jcpp.13032
- Christie L. Burton, Laura S. Park, Elizabeth Claire Corfield, Nadine Forget-Dubois, Annie Dupuis, Vanessa M. Sinopoli, Janet Shan, Tara Goodale, S-M Shaheen, Jennifer Crosbie, Russell J. Schachar, Paul D. Arnold, (2018). Heritability of obsessive–compulsive trait dimensions in youth from the general population . Translational Psychiatry doi: 10.1038/s41398-018-0249-9
- Robyn E Wootton, Rebecca B. Lawn, Maria Christine Magnus, Jorien L Treur, Elizabeth Claire Corfield, Pål Rasmus Njølstad, Ole Andreassen, Deborah A. Lawlor, Marcus R. Munafò, Siri Eldevik Håberg, George Davey Smith, Ted Reichborn-Kjennerud, Per Minor Magnus, Alexandra Havdahl, (2022). Health behaviours prior to pregnancy and fertility outcomes: Triangulation of evidence in the Norwegian Mother, Father and Child Cohort Study (MoBa)
- Elizabeth Claire Corfield, Oleksandr Frei, Alexey Shadrin, Zillur Rahman, Aihua Lin, Lavinia Athanasiu, Bayram Cevdet Akdeniz, Laurie Hannigan, Robyn Wootton, Chloe Austerberry, Amanda Hughes, Martin Steen Tesli, Lars Tjelta Westlye, Hreinn Stefansson, Kari Stefansson, Pål Rasmus Njølstad, Per Minor Magnus, Davies Neil Martin, Vivek Appadurai, Gibran Hemani, Eivind Hovig, Tetyana Zayats, Helga Ask, Ted Reichborn-Kjennerud, Ole Andreassen, Alexandra Havdahl, (2022). The Norwegian Mother, Father, and Child cohort study (MoBa) genotyping data resource: MoBaPsychGen pipeline v.1
- Amanda Hughes, Elizabeth Claire Corfield, Gibran Hemani, Neil M. Davies, Alexandra Havdahl, (2021). NIPH PsychGen and MRC IEU post-imputation QC of MoBaGenetics release 1.0, version 1
- Ragna Bugge Askeland, Laurie John Hannigan, Helga Ask, Ziada Ayorech, Martin Steen Tesli, Elizabeth Corfield, Per Magnus, Pål Rasmus Njølstad, Ole Andreas Andreassen, George Davey smith, Ted Reichborn-Kjennerud, Alexandra Havdahl, (2020). Early manifestations of genetic risk for neurodevelopmental disorders
- Laurie John Hannigan, Ragna Bugge Askeland, Helga Ask, Martin Steen Tesli, Elizabeth Corfield, Ziada Ayorech, Per Magnus, Pål Rasmus Njølstad, Anne-Siri Øyen, Camilla Stoltenberg, Ole Andreas Andreassen, George Davey smith, Ted Reichborn-Kjennerud, Alexandra Havdahl, (2020). Developmental milestones in early childhood and genetic liability to neurodevelopmental disorders
- Elizabeth Claire Corfield, Dale R. Nyholt, (2017). Characterising the relationship between fatigue and depression
- Dinka Smajlagic, Stella Tsotsi, Miriam Gjerdevik, Christian Magnus Page, Tetyana Zayats, Chloe Austerberry, Nikolai Olavi Czajkowski, Robert Lyle, Per Minor Magnus, Håkon K. Gjessing, Elizabeth Claire Corfield, Alexandra Havdahl, Ole Andreassen, Mona Bekkhus, (2022). Parent-of-origin effects in childhood aggression.
- Laurie John Hannigan, Laura Hegemann, Helga Ask, Elizabeth Claire Corfield, Alexandra Havdahl, (2022). Latent polygenic profile analysis (LPPA) as a tool for dimension reduction and exploring the phenotypic correlates of overlapping genetic liabilities .
- Elizabeth Claire Corfield, (2022). MoBa genotyping: The MoBaPsychGen pipeline_v1 .
- Laurie John Hannigan, Ingunn Olea Lund, Adrian Dahl Askelund, Eivind Ystrøm, Elizabeth Claire Corfield, Helga Ask, Alexandra Karoline Saasen Havdahl, (2022). Gene-environment interplay in associations between maternal at-risk drinking and early childhood emotional and behavioural development in the Norwegian Mother, Father, and Child Cohort.
- Elizabeth Claire Corfield, Alexey Shadrin, Oleksandr Frei, Zillur Rahman, Aihua Lin, Lavinia Athanasiu, Bayram Cevdet Akdeniz, Laurie John Hannigan, Robyn E Wootton, Chloe Austerberry, Tetyana Zayats, Helga Ask, Ted Reichborn-Kjennerud, Ole Andreassen, Alexandra Havdahl, (2022). Genetic profile of the Norwegian Mother, Father, and Child Cohort Study (MoBa): Results from the MoBaPsychGen pipeline.
- Elizabeth Claire Corfield, Oleksandr Frei, Alexey Shadrin, Zillur Rahman, Aihua Lin, Lavinia Athanasiu, Bayram Cevdet Akdeniz, Laurie John Hannigan, Robyn E Wootton, Chloe Austerberry, Amanda Hughes, Martin Steen Tesli, Lars Tjelta Westlye, Hreinn Stefánsson, Kári Stefánsson, Pål Rasmus Njølstad, Per Minor Magnus, Neil M. Davies, Vivek Appadurai, Gibran Hemani, Eivind Hovig, Tetyana Zayats, Helga Ask, Ted Reichborn-Kjennerud, Ole Andreassen, Alexandra Havdahl, (2022). The Norwegian Mother, Father, and Child cohort study (MoBa) genotyping data resource: the MoBaPsychGen_v1 pipeline.
- Elizabeth Claire Corfield, (2022). Pre-imputation QC, imputation, and post-imputation QC.
- Adrian Dahl Askelund, Laura Hegemann, Elizabeth Claire Corfield, Helga Ask, Eivind Ystrøm, Alexandra Havdahl, Laurie John Hannigan, (2022). The genomics of psychiatric symptom differentiation in early life.
- Ragna Bugge Askeland, Laurie John Hannigan, Kevin Sean O'Connell, Elizabeth Claire Corfield, Oleksandr Frei, Anita Thapar, George Davey-Smith, Ted Reichborn-Kjennerud, Ole Andreassen, Helga Ask, Alexandra Havdahl, (2022). Developmental manifestations of polygenic risk for bipolar disorder from infancy to middle childhood.
- Laura Hegemann, Ragna Bugge Askeland, Elizabeth Claire Corfield, Adrian Dahl Askelund, Laurie John Hannigan, Alexandra Havdahl, (2022). Exploring shared genetic liability across early neurodevelopmental delays and atypicalities in the general population.
- Elizabeth Claire Corfield, (2021). Pre-imputation QC, imputation, and post-imputation QC.
- Laurie John Hannigan, Elizabeth Corfield, Guido Biele, Kate Tilling, Tom A. McAdams, Isabella Badini, George Davey Smith, Tom G. Richardson, Rosie Cornish, Martin Steen Tesli, Ragna Bugge Askeland, Per Minor Magnus, Ole Andreassen, Pål Rasmus Njølstad, Eivind Ystrom, Camilla Stoltenberg, Ted Reichborn-Kjennerud, Helga Ask, Alexandra Havdahl, (2021). The genomic basis of participation in the Norwegian Mother, Father and Child Cohort Study.
- Ziada Ayorech, Neil Davies, Robyn Wootton, Hunna J Watson, Laurie John Hannigan, Ragna Bugge Askeland, Elizabeth Corfield, Martin Steen Tesli, Anne-Siri Øyen, Pål R. Njølstad, Per Minor Magnus, Ole Andreassen, Ted Reichborn-Kjennerud, George Davey Smith, Cynthia M Bulik, Helga Ask, Alexandra Havdahl, (2021). Differential causal risk patterns in childhood eating behaviours compared to adulthood anorexia nervosa. A Mendelian randomization study.
- Elizabeth Corfield, (2020). Update: QC and Imputation of the MoBa genetic data .
- Elizabeth Corfield, (2020). Overview of MoBa Genetics Release 1.
- Ragna Bugge Askeland, Laurie John Hannigan, Helga Ask, Ziada Ayorech Lennox, Martin Steen Tesli, Elizabeth Corfield, George Davey-Smith, Ted Reichborn-Kjennerud, Alexandra Havdahl, (2020). Genetic risk factors for neurodevelopmental disorders.
- Zhiyu Yang, Hanrui Wu, Phil Lee, Fotis Tsetsos, Lea Davies, Dongmei Yu, Sang Hong Lee, Soren Dalsgaard, Jan Haavik, Csaba Barta, Tetyana Zayats, Elizabeth Claire Corfield, Valsamma Eapen, Naomi R. Wray, Bernie Devlin, (2019). Cross-disorder meta-analysis of genomewide association studies sheds light into potentially shared neurobiology across ADHD, ASD, OCD, and TS.
- Martin Steen Tesli, Elizabeth Corfield, Tetyana Zayats, Helga Ask, Ragna Bugge Askeland, Laurie Hannigan, Elise Robinson, Ole Andreas Andreassen, Alexandra Havdahl, Ted Reichborn-Kjennerud, (2019). Investigation of shared genetic risk between cardiometabolic morbidity and ADHD in a Norwegian family cohort using polygenic transmission disequilibrium test.
- Elizabeth Claire Corfield, Christie L. Burton, Lisa J. Strug, Bowei Xiao, Paul D. Arnold, Jennifer Crosbie, Russell J. Schachar, (2018). Characterizing the Genetics of ADHD Traits with Cognitive Deficits Using a Multivariate Approach.
- Christie L. Burton, Bowei Xiao, Elizabeth Claire Corfield, Paul D. Arnold, Russell J. Schachar, Jennifer Crosbie, (2018). Polygenic risk for childhood-onset psychiatric disorders predicts childhood psychiatric traits in the community.
- Elizabeth Claire Corfield, Christie L. Burton, Lisa J. Strug, Bowei Xiao, Paul D. Arnold, Jennifer Crosbie, Russell J. Schachar, (2018). Characterizing the genetics of ADHD traits with cognitive deficits using a multivariate approach.