Jørn Andreas Holme

Forskningssjef, PhD og DSc i Toxikologi

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Telefon: 21 07 76 22

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Besøksadresse

Lovisenberggata 8, 0456 Oslo

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Prosjekter

Effekten av miljøforurensning på primære humane blod monocytter og makrofager

Publikasjoner

Vitenskapelige artikler og bokkapitler Rapporter og bøker Andre

Jørn Andreas Holme, Bendik Christian Brinchmann, Magne Arnold Refsnes, Marit Låg, Johan Øvrevik, (2019). Potential role of polycyclic aromatic hydrocarbons as mediators of cardiovascular effects from combustion particles. Environmental health. ISSN 1476-069X. 18:74 s 1-18. doi: 10.1186/s12940-019-0514-2.
Elisabeth Øya, Anita Solhaug, Anette Kocbach Bølling, Reidun Øvstebø, Tonje Berg Steensen, Komlavi Anani Afanou, Jørn Andreas Holme, (2019). Pro-inflammatory responses induced by A. fumigatus and A. versicolor in various human macrophage models. Journal of Toxicology and Environmental Health, Part A. ISSN 1528-7394. 82 (8), s 483-501. doi: 10.1080/15287394.2019.1619114.
Jørn Andreas Holme, Bendik Christian Brinchmann, Eric Le Ferrec, Dominique Lagadic-Gossmann, Johan Øvrevik, (2019). Combustion particle-induced changes in calcium homeostasis: A contributing factor to vascular disease?. Cardiovascular Toxicology. ISSN 1530-7905. 19 (3), s 198-209. doi: 10.1007/s12012-019-09518-9.
Bendik Christian Brinchmann, Eric Le Ferrec, Normand Podechard, Dominique Lagadic-Gossmann, Jørn Andreas Holme, Johan Øvrevik, (2019). Organic chemicals from diesel exhaust particles affects intracellular calcium, inflammation and β-adrenoceptors in endothelial cells. Toxicology Letters. ISSN 0378-4274. 302 s 18-27. doi: 10.1016/j.toxlet.2018.11.009.
Elisabeth Øya, Rune Becher, Leni Johanne Ekeren, Komlavi Anani Afanou, Johan Øvrevik, Jørn Andreas Holme, (2019). Pro-Inflammatory Responses in Human Bronchial Epithelial Cells Induced by Spores and Hyphal Fragments of Common Damp Indoor Molds. International Journal of Environmental Research and Public Health. ISSN 1660-4601. 16 (6), doi: 10.3390/ijerph16061085.
Vegard Sæter Grytting, Bergitte Olderbø, Jørn Andreas Holme, Jan Tore Samuelsen, Anita Solhaug, Rune Becher, Anette Kocbach Bølling, (2019). Di-n-butyl phthalate modifies PMA-induced macrophage differentiation of THP-1 monocytes via PPARγ. Toxicology in Vitro. ISSN 0887-2333. 54 s 168-177. doi: 10.1016/j.tiv.2018.09.004.
Elisabeth Øya, Fikirte Debebe Zegeye, Anette Kocbach Bølling, Reidun Øvstebø, Komlavi Anani Afanou, Johan Øvrevik, Magne Arnold Refsnes, Jørn Andreas Holme, (2019). Hyphae fragments from A. fumigatus sensitize lung cells to silica particles (Min-U-Sil): Increased release of IL-1?. Toxicology in Vitro. ISSN 0887-2333. 55 s 1-10. doi: 10.1016/j.tiv.2018.11.002.
Bendik Christian Brinchmann, Eric Le Ferrec, William H Bisson, Normand Podechard, Henrik Huitfeldt, Isabelle Gallais, Odile Sergent, Jørn Andreas Holme, Dominique Lagadic-Gossmann, Johan Øvrevik, (2018). Evidence of Selective Activation of Aryl Hydrocarbon Receptor Nongenomic Calcium Signaling by Pyrene. Biochemical Pharmacology. ISSN 0006-2952. 158 s 1-12. doi: 10.1016/j.bcp.2018.09.023.
Eleonora Longhin, Jørn Andreas Holme, Maurizio Gualtieri, Marina Camatini, Johan Øvrevik, (2018). Milan winter fine particulate matter (wPM2.5) induces IL-6 and IL-8 synthesis in human bronchial BEAS-2B cells, but specifically impairs IL-8 release. Toxicology in Vitro. ISSN 0887-2333. 52 s 365-373. doi: 10.1016/j.tiv.2018.07.016.
Iselin Rynning, Jiri Neca, Kristyna Vrbova, Helena Libalova, Pavel Rossner, Jørn Andreas Holme, Kristine Bjerve Gutzkow, Komlavi Anani Afanou, Yke Jildouw Arnoldussen, Eva Hruba, Øivind Skare, Aage Haugen, Jan Topinka, Miroslav Machala, Steen Kristen Mollerup, (2018). In vitro transformation of human bronchial epithelial cells by diesel exhaust particles. Gene expression profiling and early toxic responses. Toxicological Sciences. ISSN 1096-6080. 166 (1), s 51-64. doi: 10.1093/toxsci/kfy183.
Bendik Christian Brinchmann, Eric Le Ferrec, Normand Podechard, Dominique Lagadic-Gossmann, Kenji F. Shoji, Aubin Penna, Klara Kukowski, Alena Kubátová, Jørn Andreas Holme, Johan Øvrevik, (2018). Lipophilic chemicals from diesel exhaust particles trigger calcium response in human endothelial cells via aryl hydrocarbon receptor non-genomic signalling. International Journal of Molecular Sciences. ISSN 1422-0067. 19 (5), doi: 10.3390/ijms19051429.
Bendik Christian Brinchmann, Tonje Schwach Skuland, Mia Marie-Elisabeth Rambøl, Krisztina Szöke, Jan E. Brinchmann, Arno C. Gutleb, Elisa Moschini, Alena Kubátová, Klara Kukowski, Eric Le Ferrec, Dominique Lagadic-Gossmann, Per Everhard Schwarze, Marit Låg, Magne Arnold Refsnes, Johan Øvrevik, Jørn Andreas Holme, (2018). Lipophilic components of diesel exhaust particles induce pro-inflammatory responses in human endothelial cells through AhR dependent pathway(s). Particle and Fibre Toxicology. ISSN 1743-8977. 15 doi: 10.1186/s12989-018-0257-1.
Oddvar Myhre, Marit Låg, Gro Dehli Villanger, Bente Margaret Oftedal, Johan Øvrevik, Jørn Andreas Holme, Heidi Aase, Ragnhild Elisabeth Paulsen, Anna Bal-Price, Hubert Dirven, (2018). Early life exposure to air pollution particulate matter (PM) as risk factor for attention deficit/hyperactivity disorder (ADHD): Need for novel strategies for mechanisms and causalities. Toxicology and Applied Pharmacology. ISSN 0041-008X. 354 s 196-214. doi: 10.1016/j.taap.2018.03.015.
Hanne Friis Berntsen, Anette Kocbach Bølling, Cesilie Granum Bjørklund, Karin Elisabeth Zimmer, Erik Ropstad, Shanbeh Zienolddiny, Rune Becher, Jørn Andreas Holme, Hubert Dirven, Unni Cecilie Nygaard, Johanna Eva Bodin, (2018). Decreased macrophage phagocytic function due to xenobiotic exposures in vitro, difference in sensitivity between various macrophage models. Food and Chemical Toxicology. ISSN 0278-6915. 112 s 86-96. doi: 10.1016/j.fct.2017.12.024.
Elisabeth Øya, Komlavi Anani Afanou, Nabin Malla, Silvio Uhlig, Elin Rolen, Ida Skaar, Anne Straumfors, Jan-Olof Winberg, Berit Bang, Per E Schwarze, Wijnand Eduard, Jørn Andreas Holme, (2018). Characterization and pro-inflammatory responses of spore and hyphae samples from various mold species. Indoor Air: International Journal of Indoor Environment and Health. ISSN 0905-6947. 28 (1), s 28-39. doi: 10.1111/ina.12426.
Johan Øvrevik, Magne Refsnes, Marit Låg, Bendik Christian Brinchmann, Per E Schwarze, Jørn Andreas Holme, (2017). Triggering mechanisms and Inflammatory effects of combustion exhaust particles with implication for carcinogenesis. Basic & Clinical Pharmacology & Toxicology. ISSN 1742-7835. 121 s 55-62. doi: 10.1111/bcpt.12746.
Nina Mickelson Weldingh, Lena Jørgensen-Kaur, Rune Becher, Jørn Andreas Holme, Johanna Bodin, Unni Cecilie Nygaard, Anette Kocbach Bølling, (2017). Bisphenol A Is More Potent than Phthalate Metabolites in Reducing Pancreatic -Cell Function. BioMed Research International. ISSN 2314-6133. 2017 doi: 10.1155/2017/4614379.
Anette Kocbach Bølling, Anita Solhaug, Else Morisbak, Jørn Andreas Holme, Jan Tore Samuelsen, (2017). The dental monomer hydroxyethyl methacrylate (HEMA) counteracts lipopolysaccharide-induced IL-1β release – Possible role of glutathione. Toxicology Letters. ISSN 0378-4274. 270 s 25-33. doi: 10.1016/j.toxlet.2017.02.007.
Kévin Hardonnière, Laurence Huc, Odile Sergent, Jørn Andreas Holme, Dominique Lagadic-Gossmann, (2017). Environmental carcinogenesis and pH homeostasis: Not only a matter of dysregulated metabolism. Seminars in Cancer Biology. ISSN 1044-579X. 43 s 49-65. doi: 10.1016/j.semcancer.2017.01.001.
Anita Solhaug, Gunnar Sundstøl Eriksen, Jørn Andreas Holme, (2016). Mechanisms of Action and Toxicity of the Mycotoxin Alternariol: A Review. Basic & Clinical Pharmacology & Toxicology. ISSN 1742-7835. 119 (6), s 533-539. doi: 10.1111/bcpt.12635.
Anita Solhaug, Line Merete Karlsøen, Jørn Andreas Holme, Anja Bråthen Kristoffersen, Gunnar Sundstøl Eriksen, (2016). Immunomodulatory effects of individual and combined mycotoxins in the THP-1 cell line. Toxicology in Vitro. ISSN 0887-2333. 36 s 120-132. doi: 10.1016/j.tiv.2016.07.012.
Marit Låg, Johan Øvrevik, Annike Irene Totlandsdal, Edel Lilleaas, Anders Thormodsæter, Jørn Andreas Holme, Per E Schwarze, Magne Refsnes, (2016). Air pollution-related metals induce differential cytokine responses in bronchial epithelial cells. Toxicology in Vitro. ISSN 0887-2333. 36 s 53-65. doi: 10.1016/j.tiv.2016.07.004.
Eleonora Longhin, Maurizio Gualtieri, Lauro Capasso, Rossella Bengalli, Steen Kristen Mollerup, Jørn Andreas Holme, Johan Øvrevik, Simone Casadei, Christiano Di Benedetto, Paolo Parenti, Marina Camatini, (2016). Physico-chemical properties and biological effects of diesel and biomass particles. Environmental Pollution (1987). ISSN 0269-7491. 215 s 366-375. doi: 10.1016/j.envpol.2016.05.015.
Johan Øvrevik, Magne Refsnes, Marit Låg, Jørn Andreas Holme, Per E Schwarze, (2015). Activation of proinflammatory responses in cells of the airway mucosa by particulate matter: Oxidant- and non-oxidant-mediated triggering mechanisms. Biomolecules. ISSN 2218-273X. 5 (3), s 1399-1440. doi: 10.3390/biom5031399.
Nicolai S Bach, Anette Kocbach Bølling, Bendik Christian Brinchmann, Annike Irene Totlandsdal, Tonje Schwach Skuland, Jørn Andreas Holme, Marit Låg, Per E Schwarze, Johan Øvrevik, (2015). Cytokine responses induced by diesel exhaust particles are suppressed by PAR-2 silencing and antioxidant treatment, and driven by polar and non-polar soluble constituents. Toxicology Letters. ISSN 0378-4274. 238 (2), s 72-82. doi: 10.1016/j.toxlet.2015.07.002.
Anita Solhaug, Cathrine Wisbech, Trine Eker Christoffersen, Lene Therese Olsen Hult, Tor Erling Lea, Gunnar Sundstøl Eriksen, Jørn Andreas Holme, (2015). The mycotoxin alternariol induces DNA damage and modify macrophage phenotype and inflammatory responses. Toxicology Letters. ISSN 0378-4274. 239 (1), s 9-21. doi: 10.1016/j.toxlet.2015.08.1107.
Anita Solhaug, Maria Lyngaas Torgersen, Jørn Andreas Holme, Dominique Lagadic-Gossmann, Gunnar Sundstøl Eriksen, (2014). Autophagy and senescence, stress responses induced by the DNA-damaging mycotoxin alternariol. Toxicology. ISSN 0300-483X. 326 s 119-129. doi: 10.1016/j.tox.2014.10.009.
Johan Øvrevik, Marit Låg, Valerie Lecureur, David Gilot, Dominique Lagadic-Gossmann, Magne Refsnes, Per E Schwarze, Tonje Schwach Skuland, Rune Becher, Jørn Andreas Holme, (2014). AhR and Arnt differentially regulate NF-κB signaling and chemokine responses in human bronchial epithelial cells. Cell Communication and Signaling. ISSN 1478-811X. 12 (1), doi: 10.1186/s12964-014-0048-8.
Jørn Andreas Holme, Hannah Elise Nyvold, V Tat, V M Arlt, A Bhargava, Kristine Bjerve Gutzkow, Anita Solhaug, Marit Låg, Rune Becher, Per E Schwarze, K Ask, Leni Johanne Ekeren, Johan Øvrevik, (2014). Mechanisms linked to differences in the mutagenic potential of 1,3-dinitropyrene and 1,8-dinitropyrene. Toxicology reports. ISSN 2214-7500. 1 s 459-473. doi: 10.1016/j.toxrep.2014.07.009.
Béatrice Dendele, Xavier Tekpli, Kevin Hardonniere, Jørn Andreas Holme, Laure Debure, Daniel Catheline, Volker M Arlt, Eszter Nagy, David H Phillips, Steinar Øvrebø, Steen Kristen Mollerup, Mallory Poët, Martine Chevanne, Vincent Rioux, Marie-Thérèse Dimanche-Boitrel, Odile Sergent, Dominique Lagadic-Gossmann, (2014). Protective action of n-3 fatty acids on benzo[a]pyrene-induced apoptosis through the plasma membrane remodeling-dependent NHE1 pathway. Chemico-Biological Interactions. ISSN 0009-2797. 207 (1), s 41-51. doi: 10.1016/j.cbi.2013.11.002.
Annike Irene Totlandsdal, Johan Øvrevik, Richard Cocheran, Jan Inge Herseth, Anette Kocbach Bølling, Marit Låg, Per E Schwarze, Edel Lilleaas, Jørn Andreas Holme, Alena Kubatova, (2014). The occurrence of polycyclic aromatic hydrocarbons and their derivatives and the proinflammatory potential of fractionated extracts of diesel exhaust and wood smoke particles. Journal of Environmental Science and Health. Part A: Toxic/Hazardous Substances and Environmental Engineering. ISSN 1093-4529. 49 (4), s 383-396. doi: 10.1080/10934529.2014.854586.
Eleonora Longhin, Jørn Andreas Holme, Kristine Bjerve Gutzkow, Volker Arlt, Jill E. Kucab, Marina Camatini, Maurizio Gualtieri, (2013). Cell cycle alterations induced by urban PM2.5 in bronchial epithelial cells: characterization of the process and possible mechanisms involved. Particle and Fibre Toxicology. ISSN 1743-8977. 10 doi: 10.1186/1743-8977-10-63.
Anette Kocbach Bølling, Jørn Andreas Holme, Carl Gustaf Bornehag, Unni Cecilie Nygaard, Randi Jacobsen Bertelsen, Eewa Nånberg, Johanna Bodin, Amrit Kaur Sakhi, Cathrine Thomsen, Rune Becher, (2013). Pulmonary phthalate exposure and asthma - is PPAR a plausible mechanistic link?. EXCLI Journal. ISSN 1611-2156. 12 s 733-759.
Abderrahim Nemmar, Jørn Andreas Holme, Irma Rosas, Per E Schwarze, Ernesto Alfaro-Moreno, (2013). Recent advances in particulate matter and nanoparticle toxicology: a review of the in vivo and in vitro studies. BioMed Research International. ISSN 2314-6133. 2013 doi: 10.1155/2013/279371.
Johan Øvrevik, Magne Refsnes, Jørn Andreas Holme, Per E Schwarze, Marit Låg, (2013). Mechanisms of chemokine responses by polycyclic aromatic hydrocarbons in bronchial epithelial cells: sensitization through toll-like receptor-3 priming. Toxicology Letters. ISSN 0378-4274. 219 (2), s 125-132. doi: 10.1016/j.toxlet.2013.02.014.
Johan Øvrevik, Jørn Andreas Holme, Marit Låg, Per E Schwarze, Magne Refsnes, (2013). Differential chemokine induction by 1-nitropyrene and 1-aminopyrene in bronchial epithelial cells: Importance of the TACE/TGF-alpha/EGFR-pathway. Environmental Toxicology and Pharmacology. ISSN 1382-6689. 35 (2), s 235-239. doi: 10.1016/j.etap.2012.12.011.
Xavier Tekpli, Jørn Andreas Holme, Odile Sergent, Dominique Lagadic-Gossmann, (2013). Role for membrane remodeling in cell death: Implication for health and disease. Toxicology. ISSN 0300-483X. 304 s 141-157. doi: 10.1016/j.tox.2012.12.014.
Per E Schwarze, Annike Irene Totlandsdal, Marit Låg, Magne Refsnes, Jørn Andreas Holme, Johan Øvrevik, (2013). Inflammation-Related Effects of Diesel Engine Exhaust Particles: Studies on Lung Cells In Vitro. Biomedical research. ISSN 0388-6107. doi: 10.1155/2013/685142.
Anita Solhaug, Jørn Andreas Holme, Kaisa Haglund, B Dendele, O Sergent, J Pestka, Dominique Lagadic-Gossmann, Gunnar Sundstøl Eriksen, (2013). Alternariol induces abnormal nuclear morphology and cell cycle arrest in murine RAW 264.7 macrophages. Toxicology Letters. ISSN 0378-4274. 219 (1), s 8-17. doi: 10.1016/j.toxlet.2013.02.012.
E. Longhin, E. Pezzolato, P. Mantecca, Jørn Andreas Holme, A. Franzetti, M. Camatini, M. Gualtieri, (2013). Season linked responses to fine and quasi-ultrafine Milan PM in cultured cells. Toxicology in Vitro. ISSN 0887-2333. 27 (2), s 551-559. doi: 10.1016/j.tiv.2012.10.018.
Wiggo Johan Sandberg, Marit Låg, Jørn Andreas Holme, Bernd Friede, Maurizio Gualtieri, Marcin Kruszewski, Per E Schwarze, Tonje Schwach Skuland, Magne Refsnes, (2012). Comparison of non-crystalline silica nanoparticles in IL-1 beta release from macrophages. Particle and Fibre Toxicology. ISSN 1743-8977. 9 doi: 10.1186/1743-8977-9-32.
Anita Solhaug, Laura Vines, Lada Ivanova, Bjørn Spilsberg, Jørn Andreas Holme, James J. Pestka, Andrew Richard Collins, Gunnar Sundstøl Eriksen, (2012). Mechanisms involved in alternariol-induced cell cycle arrest. Mutation research. ISSN 0027-5107. 738-739 s 1-11. doi: 10.1016/j.mrfmmm.2012.09.001.
Xavier Tekpli, Laurence Huc, Odile Sergent, Beatrice Dendele, Marie-Thérèse Dimanche-Boitrel, Jørn Andreas Holme, Dominique Lagadic-Gossmann, (2012). NHE-1 Relocation Outside Cholesterol-rich Membrane Microdomains is Associated with its Benzo[a]pyrene-related Apoptotic Function. Cellular Physiology and Biochemistry. ISSN 1015-8987. 29 (5-6), s 657-666. doi: 10.1159/000171027.
Jan Tore Samuelsen, Jørn Andreas Holme, Marit Låg, Per E Schwarze, Jon Einar Dahl, Rune Becher, (2012). Biotransformation enzymes and lung cell response to 2-hydroxyethyl-methacrylate. Journal of Biomedical Materials Research. Part A. ISSN 1549-3296. 100A (2), s 462-469. doi: 10.1002/jbm.a.33287.
Béatrice Dendele, Xavier Tekpli, Odile Sergent, Marie-Thérèse Dimanche-Boitrel, Jørn Andreas Holme, Laurence Huc, Dominique Lagadic-Gossmann, (2012). Identification of the couple GSK3 alpha/c-Myc as a new regulator of hexokinase II in benzo[a]pyrene-induced apoptosis. Toxicology in Vitro. ISSN 0887-2333. 26 (1), s 94-101. doi: 10.1016/j.tiv.2011.11.001.
Anders Ø. Gammelsrud, Anita Solhaug, B Dendele, Wiggo Johan Sandberg, Lada Ivanova, Anette Kocbach Bølling, D Lagadic-Gossmann, Magne Refsnes, Rune Becher, Gunnar Sundstøl Eriksen, Jørn Andreas Holme, (2012). Enniatin B-induced cell death and inflammatory responses in RAW 267.4 murine macrophages. Toxicology and Applied Pharmacology. ISSN 0041-008X. 261 (1), s 74-87. doi: 10.1016/j.taap.2012.03.014.
Anette Kocbach Bølling, Johan Øvrevik, Jan Tore Samuelsen, Jørn Andreas Holme, Kirsten Eline Rakkestad, Gro Haarklou Mathisen, Ragnhild Elisabeth Paulsen, Monica Suarez Korsnes, Rune Becher, (2012). Mono-2-ethylhexylphthalate (MEHP) induces TNF-alpha release and macrophage differentiation through different signalling pathways in RAW264.7 cells. Toxicology Letters. ISSN 0378-4274. 209 (1), s 43-50. doi: 10.1016/j.toxlet.2011.11.016.
Johan Øvrevik, Magne Refsnes, Annike Irene Totlandsdal, Jørn Andreas Holme, Per E Schwarze, Marit Låg, (2011). TACE/TGF-a/EGFR regulates CXCL8 in bronchial epithelial cells exposed to particulate matter components. European Respiratory Journal. ISSN 0903-1936. 38 (5), s 1189-1199. doi: 10.1183/09031936.00171110.
N Podechard, X Tekpli, D Catheline, Jørn Andreas Holme, V Rioux, P Legrand, M Rialland, O Fardel, D Lagadic-Gossmann, V Lecureur, (2011). Mechanisms involved in lipid accumulation and apoptosis induced by 1-nitropyrene in Hepa1c1c7 cells. Toxicology Letters. ISSN 0378-4274. 206 (3), s 289-299. doi: 10.1016/j.toxlet.2011.07.024.
X Tekpli, Jørn Andreas Holme, O Sergent, D Lagadic-Gossmann, (2011). Importance of Plasma Membrane Dynamics in Chemical-Induced Carcinogenesis. Recent Patents on Anti-Cancer Drug Discovery. ISSN 1574-8928. 6 (3), s 347-353.
Vibeke Ansteinsson, Anita Solhaug, Jan Tore Samuelsen, Jørn Andreas Holme, Jon Einar Dahl, (2011). DNA-damage, cell-cycle arrest and apoptosis induced in BEAS-2B cells by 2-hydroxyethyl methacrylate (HEMA). Mutation Research. Genetic Toxicology and Environmental Mutagenesis. ISSN 1383-5718. 723 (2), s 158-164. doi: 10.1016/j.mrgentox.2011.04.011.
Elisabeth Øya, Johan Øvrevik, Volker M Arlt, Eszter Nagy, David H Phillips, Jørn Andreas Holme, (2011). DNA damage and DNA damage response in human bronchial epithelial BEAS-2B cells following exposure to 2-nitrobenzanthrone and 3-nitrobenzanthrone: role in apoptosis. Mutagenesis. ISSN 0267-8357. 26 (6), s 697-708. doi: 10.1093/mutage/ger035.
Maurizio Gualtieri, Johan Øvrevik, Steen Kristen Mollerup, Nana Asare, Eleonora Longhin, Hans-Jørgen Dahlman, Marina Camatini, Jørn Andreas Holme, (2011). Airborne urban particles (Milan winter-PM2.5) cause mitotic arrest and cell death: Effects on DNA, mitochondria, AhR binding and spindle organization. Mutation research. ISSN 0027-5107. 713 (1-2), s 18-31. doi: 10.1016/j.mrfmmm.2011.05.011.
Jan Tore Samuelsen, Hilde Beate M. Kopperud, Jørn Andreas Holme, Inger Sofie Dragland, Terje Christensen, Jon Einar Dahl, (2011). Role of thiol-complex formation in 2-hydroxyethyl-methacrylate-induced toxicity in vitro. Journal of Biomedical Materials Research. Part A. ISSN 1549-3296. 96A (2), s 395-401. doi: 10.1002/jbm.a.32993.
Johan Øvrevik, VM Arlt, E Øya, E Nagy, Steen Kristen Mollerup, DH Phillips, Marit Låg, Jørn Andreas Holme, (2010). Differential effects of nitro-PAHs and amino-PAHs on cytokine and chemokine responses in human bronchial epithelial BEAS-2B cells. Toxicology and Applied Pharmacology. ISSN 0041-008X. 242 (3), s 270-280. doi: 10.1016/j.taap.2009.10.017.
Maurizio Gualtieri, Johan Øvrevik, Jørn Andreas Holme, M Grazia Perrone, Ezio Bolzacchini, Per E Schwarze, Marina Camatini, (2010). Differences in cytotoxicity versus pro-inflammatory potency of different PM fractions in human epithelial lung cells. Toxicology in Vitro. ISSN 0887-2333. 24 (1), s 29-39. doi: 10.1016/j.tiv.2009.09.013.
Kirsten Eline Rakkestad, Jørn Andreas Holme, Ragnhild E Paulsen, Per E Schwarze, Rune Becher, (2010). Mono(2-ethylhexyl) phthalate induces both pro- and anti-inflammatory responses in rat alveolar macrophages through crosstalk between p38, the lipoxygenase pathway and PPAR alpha. Inhalation Toxicology. ISSN 0895-8378. 22 (2), s 140-150. doi: 10.3109/08958370903019885.
Nina Elisabeth Landvik, VM Arit, E Nagy, Anita Solhaug, X Tekpli, HH Schmeiser, Magne Refsnes, DH Phillips, D Lagadic-Gossmann, Jørn Andreas Holme, (2010). 3-Nitrobenzanthrone and 3-aminobenzanthrone induce DNA damage and cell signalling Hepa1c1c7 cells. Mutation research. ISSN 0027-5107. 684 (1-2), s 11-23. doi: 10.1016/j.mrfmmm.2009.11.004.
X Tekpli, Edgar Rivedal, M Gorria, Nina Elisabeth Landvik, M Rissel, MT Dimanche-Boitrel, G Baffet, Jørn Andreas Holme, D Lagadic-Gossmann, (2010). The B[a]P-increased intercellular communication via translocation of connexin-93 into gap junctions reduces apoptosis. Toxicology and Applied Pharmacology. ISSN 0041-008X. 242 (2), s 231-240. doi: 10.1016/j.taap.2009.10.012.
Xavier Tekpli, Mary Rissel, Laurence Huc, Daniel Catheline, Odile Sergent, Vincent Rioux, Philippe Legrand, Jørn Andreas Holme, Marie-Thérèse Dimanche-Boitrel, Dominique Lagadic-Gossmann, (2010). Membrane remodeling, an early event in benzo[a]pyrene-induced apoptosis. Toxicology and Applied Pharmacology. ISSN 0041-008X. 243 (1), s 68-76. doi: 10.1016/j.taap.2009.11.014.
Kirsten Eline Rakkestad, Hanne Ida Skaar, Vibeke E Ansteinsson, Anita Solhaug, Jørn Andreas Holme, James J Pestka, Jan T Samuelsen, Hans Jørgen Dahlman, Jan Kenneth Hongslo, Rune Becher, (2010). DNA damage and DNA damage responses in THP-1 monocytes after exposure to spores of either Stachybotrys chartarum or Aspergillus versicolor or to T-2 toxin. Toxicological Sciences. ISSN 1096-6080. 115 (1), s 140-155. doi: 10.1093/toxsci/kfq045.
Per E Schwarze, Annike Irene Totlandsdal, Jan Inge Herseth, Jørn Andreas Holme, Marit Låg, Magne Refsnes, Johan Øvrevik, Wiggo Johan Sandberg, Anette Kocbach, (2010). Importance of sources and components of particulate air pollution for cardio-pulmonary inflammatory responses.
Nana Asare, Marit Låg, Dominique Lagadic-Gossmann, Mary Rissel, Per E Schwarze, Jørn Andreas Holme, (2009). 3-Nitrofluoranthene (3-NF) but not 3-aminofluoranthene (3-AF) elicits apoptosis as well as programmed necrosis in Hepa1c1c7 cells. Toxicology. ISSN 0300-483X. 255 (3), s 140-150. doi: 10.1016/j.tox.2008.10.021.
Nana Asare, Xavier Tekpli, Mary Rissel, Anita Solhaug, Nina Landvik, Valerie Lecureur, Normand Podechard, Gunnar Brunborg, Marit Låg, Dominique Lagadic-Gossmann, Jørn Andreas Holme, (2009). Signalling pathways involved in 1-nitropyrene (1-NP)-induced and 3-nitrofluoranthene (3-NF)-induced cell death in Hepa1c1c7 cells. Mutagenesis. ISSN 0267-8357. 24 (6), s 481-493. doi: 10.1093/mutage/gep032.
Johan Øvrevik, Marit Låg, Jørn Andreas Holme, Per E Schwarze, Magne Refsnes, (2009). Cytokine and chemokine expression patterns in lung epithelial cells exposed to components characteristic of particulate air pollution. Toxicology. ISSN 0300-483X. 259 (1-2), s 46-53. doi: 10.1016/j.tox.2009.01.028.
JT Samuelsen, Jørn Andreas Holme, Rune Becher, S Karlsson, E Morisbak, JE Dahl, (2008). HEMA reduces cell proliferation and induces apoptosis in vitro. Dental Materials. ISSN 0109-5641. 24 (1), s 134-140. doi: 10.1016/j.dental.2007.08.006.
Morgane Gorria, Xavier Tekpli, Mary Rissel, Odile Sergent, Laurence Huc, Nina Landvik, Olivier Fardel, Marie-Thérèse Dimanche-Boitrel, Jørn Andreas Holme, Dominique Lagadic-Gossmann, (2008). A new lactoferrin- and iron-dependent lysosomal death pathway is induced. by benzo[a]pyrene in hepatic epithelial cells. Toxicology and Applied Pharmacology. ISSN 0041-008X. 228 (2), s 212-224. doi: 10.1016/j.taap.2007.12.021.
Nana Asare, Nina Elisabeth Landvik, Dominique Lagadic-Gossmann, Mary Rissel, Xavier Tekpli, Kjetil Ask, Marit Låg, Jørn Andreas Holme, (2008). 1-Nitropyrene (1-NP) induces apoptosis and apparently a non-apoptotic programmed cell death (paraptosis) in Hepa1c1c7 cells. Toxicology and Applied Pharmacology. ISSN 0041-008X. 230 (2), s 175-186. doi: 10.1016/j.taap.2008.02.015.
Marit Låg, Magne Refsnes, Per E Schwarze, Jørn Andreas Holme, (2008). Signaling pathways involved in cadium-induced apoptosis and cytokine release in primary lung cells.
Nina Elisabeth Landvik, Morgane Gorria, Volker Arlt, Nana Asare, Anita Solhaug, Dominique Lagadic-gossmann, Jørn Andreas Holme, (2007). Effects of nitrated-polycyclic aromatic hydrocarbons and diesel exhaust particle extracts on cell signalling related to apoptosis: Possible implications for their mutagenic and carcinogenic effects. Toxicology. ISSN 0300-483X. 231 (2-3), s 159-174. doi: 10.1016/j.tox.2006.12.009.
Laurence Huc, Xavier Tekpli, Jørn Andreas Holme, Mary Rissel, Anita Solhaug, Claire Gardyn, Gwénaelle Le Moigne, Morgane Gorria, Marie-Thérèse Dimanche-Boitrel, Dominique Lagadic-Gossmann, (2007). c-Jun NH2-terminal kinase-related Na+/H+ exchanger isoform 1 activation controls hexokinase II expression in benzo(a)pyrene-induced apoptosis. Cancer Research. ISSN 0008-5472. 67 (4), s 1696-1705. doi: 10.1158/0008-5472.CAN-06-2327.
Kirsten Eline Rakkestad, Christian Jarle Dye, Karl Espen Yttri, Jørn Andreas Holme, Jan Kenneth Hongslo, Per E Schwarze, Rune Becher, (2007). Phthalate levels in Norwegian indoor air related to particle size fraction. Journal of Environmental Monitoring. ISSN 1464-0325. 9 s 1419-1425. doi: 10.1039/b709947a.
Jørn Andreas Holme, Morgane Gorria, Volker Arlt, Steinar Øvrebø, Anita Solhaug, Xavier Tekpli, Nina Elisabeth Landvik, Laurence Huc, Olivier Fardel, Dominique Lagadic-Gossmann, (2007). Different mechanisms involved in apoptosis following exposure to benzo[a]pyrene in F258 and Hepa1c1c7 cells. Chemico-Biological Interactions. ISSN 0009-2797. 167 (1), s 41-55. doi: 10.1016/j.cbi.2007.01.008.
L Huc, Mary Rissel, Anita Solhaug, Xavier Tekpli, Morgane Gorria, Alicia Torriglia, Jørn Andreas Holme, Dominique Lagadic-Gossmann, (2006). Multiple aptotic pathways induced by p53 dependent acidification in benzo[a]pyrene-exposed hepatic F258 cells. Journal of Cellular Physiology. ISSN 0021-9541. 208 (3), s 527-537. doi: 10.1002/jcp.20686.
Kjetil Ask, Nathalie Décologne, Christian Ginies, Marit Låg, Jean Luc Boucher, Jørn Andreas Holme, Hélène Pelczar, Philippe Camus, (2006). Metabolism of nilutamide in rat lung. Biochemical Pharmacology. ISSN 0006-2952. 71 (3), s 377-385. doi: 10.1016/j.bcp.2005.10.034.
Anita Solhaug, Magne Refsnes, Jørn Andreas Holme, (2004). Role of cell signalling involved in induction of apoptosis by benzo(a)pyrene and cyclopenta(c,d)pyrene in Hepa1c1c7 cells. Journal of Cellular Biochemistry. ISSN 0730-2312. 93 (6), s 1143-1154. doi: 10.1002/jcb.20251.
Anita Solhaug, Magne Refsnes, Marit Låg, Per E Schwarze, Trine Husøy, Jørn Andreas Holme, (2004). Polycyclic aromatic hydrocarbones induce both apoptotic and anti-apoptotic signals in Hepa1c1c7 cells. Carcinogenesis. ISSN 0143-3334. 25 (5), s 809-819. doi: 10.1093/carcin/bgh069.
Ann-Karin Olsen, Nur Duale, Magnar Bjørås, Cathrine T. Larsen, Richard Wiger, Jørn A. Holme, Erling Christen Seeberg, Gunnar Brunborg, (2003). Limited repair of 8-hydroxy-7,8-dihydroguanine residues in human testicular cells. Nucleic Acids Research. ISSN 0305-1048. 31 s 1351-1363. doi: 10.1093/nar/gkg216.
Jørn A. Holme, Erik Dybing, (2002). The use of in vitro methods for hazard characterisation of chemicals. Toxicology Letters. ISSN 0378-4274. 127 s 135-41.
J Jansen, Ann-Karin Olsen, Richard Wiger, Hanspeter Naegeli, P. de Boer, F. van der Hoeven, Jørn Andreas Holme, Gunnar Brunborg, L Mullenders, (2001). Nucleotide excision repair in rat male germ cells: low level of repair in intact cells contrasts with high dual incision activity in vitro. Nucleic Acids Research. ISSN 0305-1048. 29 (8), s 1791-1800.
Ann-Karin Hardie Olsen, Helle Bjørntuft, Richard Wiger, Jørn A. Holme, Erling Christen Seeberg, Magnar Bjørås, Gunnar Brunborg, (2001). Highly efficient Base Excision Repair (BER) in human and rat male germ cells. Nucleic Acids Research. ISSN 0305-1048. 29 s 1781-1790.
Christel Olsen, E T M. Meussen-Elholm, Jørn A. Holme, Erik Dybing, J.K. Hongslo, (2001). Estrogenicity of various phenolic compounds in MCF-7 cells. Pharmacology and Toxicology. ISSN 0901-9928. 88 (suppl 1), s 22-3.
Jørn A. Holme, Magne Refsnes, Erik Dybing, (1999). Mulig kreftrisiko ved tilvirkning og bruk av kreosotimpregnert trevirke. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 119 s 2664-2666.
Solfrid Hegstad, Elsa Lundanes, Jørn A. Holme, Jan Alexander, (1999). Characterization of metabolites of benz(j)aceanthrylene in faeces, urine and bile from rat. Xenobiotica. ISSN 0049-8254. 29 s 1257-1272.
Jørn A Holme, Inger-Lise Steffensen, Gunnar Brunborg, Georg Becher, Jan Alexander, (1999). Klorering av drikkevann - mulig kreftrisiko av et biprodukt. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 119 s 2528-2530.
R. Wiger, Jørn A. Holme, J.K. Hongslo, G. Brunborg, Kari Bente Foss Haug, V. Rodilla, Erik Dybing, E.J. Søderlund, (1998). Single-strand breaks, cell cycle arrest and apoptosis in HL-60 and LLCPK<sub>1</sub> cells exposed to 1,2-dibromo-3-chloropropane. Cell Biology and Toxicology. ISSN 0742-2091. 14 s 267-282.
Jørn A. Holme, Christine Bjørge, M. Trbojevic, Ann-Karin Olsen, Gunnar Brunborg, Erik Johan Søderlund, Magnar Bjørås, Erling Christen Seeberg, Tim Scholz, Erik Dybing, Richard Wiger, (1998). Effects of chemical-induced DNA damage on male germ cells. Archives of Toxicology. ISSN 0340-5761. Suppl. 20 s 151-160. doi: 10.1007/978-3-642-46856-8_14.
Jørn A. Holme, R. Wiger, J.K. Hongslo, E.J. Søderlund, G. Brunborg, Erik Dybing, (1997). Cell death via interactions of agents with DNA. Advances in Molecular and Cell Biology. ISSN 1569-2558. 20 s 145-182.
J.K. Jeong, Erik Dybing, E.J. Søderlund, G. Brunborg, Jørn A. Holme, S.S. Lau, T.J. Monks, (1997). DNA damage gadd153 expression, and cytotoxicity in plateau-phase renal proximal tubular epithelial cells treated with a quinol thioether. Archives of Biochemistry and Biophysics. ISSN 0003-9861. 341 s 300-308.
Jørn A. Holme, Erik Dybing, (1997). Miljøkjemikalier med hormonlignende effekter: et helseproblem?. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 117 s 70-73.
U. Marstinstredet, G. Brunborg, Magnar Bjørås, E.J. Søderlund, Erling Christen Seeberg, E. Kronberg, Jørn A. Holme, (1997). DNA damage induced by chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) in HL-60 cells and purified DNA in vitro. Mutation research. ISSN 0027-5107. (390), s 171-178.
Jan K Hongslo, Gunnar Brunborg, Inger-Lise Steffensen, Jørn A Holme, (1993). Paracetamol inhibits UV-induced DNA repair in resting human mononuclear blood cells in vitro. Mutagenesis. ISSN 0267-8357. 8 (5), s 423-429.

Kirsten Eline Rakkestad, Rune Becher, Jørn Andreas Holme, (2010). Studies on indoor air pollution. Characterization of phthalates in Norwegian indoor environments, and effects of phthalates and mold on respiratory health. Unipub forlag.
Nana Asare, Jørn Andreas Holme, (2009). Differential mechanisms of cell death induced by nitro-polycyclic aromatic hydrocarbons. Unipub forlag. ISBN 978-82-8072-783-1.
Anita Solhaug, Jørn Andreas Holme, (2005). Mechanisms involved in the apoptosis induced by polycyclic aromatic hydrocarbones and cyclopenta polycyclic aromatic hydrocarbones. Unipub forlag. 100 s.

Jørn Andreas Holme, Roland Froetschl, Lisbeth E. Knudsen, (2017). The European Environmental Mutagenesis and Genomics Society Annual Meeting, 14-18 August 2016, Copenhagen, Denmark. Basic & Clinical Pharmacology & Toxicology. ISSN 1742-7835. 121 s 3-7 doi: 10.1111/bcpt.12750.
Line Merete Karlsøen, Gunnar Sundstøl Eriksen, Jørn Andreas Holme, Ketil Hylland, Anja Bråthen Kristoffersen, Anita Solhaug, (2015). Toxicity of single and combined mycotoxins to THP-1 immune cells in vitro.
Anita Solhaug, Line Merete Karlsøen, Maria Lyngaas Torgersen, Cathrine Wisbech, Tor Erling Lea, Dominique Lagadic-Gossmann, Jørn Andreas Holme, Gunnar Sundstøl Eriksen, (2014). Mycotoxins effects toxicity and differentiation of macrophages.
Anita Solhaug, Cathrine Wisbech, Trine Eker Christoffersen, Lene Therese Olsen Hult, Tor Erling Lea, Laura Vines, James J. Pestka, Jørn Andreas Holme, Gunnar Sundstøl Eriksen, (2013). Alternariol induces differentiation of macrophages.
Jørn Andreas Holme, Anders Ø. Gammelsrud, Béatrice Dendele, Wiggo Johan Sandberg, Dominique Lagadic-Gossmann, Magne Refsnes, Rune Becher, Gunnar Sundstøl Eriksen, Anita Solhaug, (2012). Mycotoxin-induced cell death and inflammatory responses in macrophages. Toxicology Letters. ISSN 0378-4274. 211 s S133-S134 doi: 10.1016/j.toxlet.2012.03.489.
Anita Solhaug, Jørn Andreas Holme, Laura Vines, Bjørn Spilsberg, James J. Pestka, Kaisa Haglund, Béatrice Dendele, Dominique Lagadic-Gossmann, Gunnar Sundstøl Eriksen, (2012). Alternariol-induced ROS causes DNA damage and accumulation in the G2/M transition. Toxicology Letters. ISSN 0378-4274. 211 s S119-S119 doi: 10.1016/j.toxlet.2012.03.439.
Béatrice Dendele, Odile Sergent, Xavier Tekpli, Volker Manfred Arlt, Eszter Nagy, Steinar Øvrebø, Jørn Andreas Holme, Dominique Lagadic-Gossmann, (2011). Effects of the omega-3 DHA and EPA on benzo[a]pyrene-induced apoptosis in liver epithelial cells. Toxicology Letters. ISSN 0378-4274. 205 s S121-S122 doi: 10.1016/j.toxlet.2011.05.436.
Anette Kocbach Bølling, Monica Suarez Korsnes, Jørn Andreas Holme, Rune Becher, (2010). Mono-2-ethylhexylphthalate(MEHP)activates both-pro- and anti-inflammatory signals..
Jørn Andreas Holme, Xavier Tekpli, B Dendele, L. Debure, O Sergent, M Rissel, L Huc, D Catheline, V Rioux, P Legrand, M Dimanche-Boitrel, D Lagadic-Gossmann, (2010). Ahr-dependent lipid membrane remodeling: an early step facilitating benzo[a]pyrene-induced apoptosis. The Toxicologist. ISSN 0731-9193. 114 (1), s 128-128
Marit Låg, Johan Øvrevik, Edel Lilleaas, Magne Refsnes, Anders Thormodsæter, Annike Irene Totlandsdal, Jørn Andreas Holme, Per E Schwarze, (2010). Metals related to particulate matter induced differential cytokine responses in human epithelial lung cells. The Toxicologist. ISSN 0731-9193. 114 (1), s 462-463
Johan Øvrevik, Marit Låg, V Lecureur, D Gilot, S Møllerup, D Lagadic-Gossmann, O Fardel, Magne Refsnes, Per E Schwarze, Jørn Andreas Holme, (2010). Differential effects of 1-nitropyrene and 1-aminopyrene on CXCL8 (IL-8) and CCL5 (rantes) in beas-2B cells: role of AHR, ARNT, NF-KB and AP-1. The Toxicologist. ISSN 0731-9193. 114 (1), s 156-157
Anita Solhaug, Jørn Andreas Holme, Lada Ivanova, Gunnar Sundstøl Eriksen, (2009). Alternariol induces DNA damage and differensiation of RAW 264.7 cells.
Nana Asare, Dominique Lagadic-Gossmann, Jørn Andreas Holme, (2009). 3-nitrofluoranthene (3-NF)-induced apoptosis and programmed necrosis. Autophagy. ISSN 1554-8627. 5 (5), s 751-752 doi: 10.4161/auto.5.5.8790.
E Øya, Johan Øvrevik, S Mollerup, Hans Jørgen Dahlman, Leni Johanne Ekeren, Jørn Andreas Holme, (2009). Effects of nitro- and amino-PAHs on apoptotic signaling in bronchial epithelial cells. Toksikologen. ISSN 1504-5773. 19 (1), s 16-17
Marina Camatini, Maurizio Gualtieri, Paride Mantecca, Johan Øvrevik, Jørn Andreas Holme, (2008). Seasonal and dimensional differences in pro-inflammatory potency of the atmospheric particulate matter of Milano on lung cell lines. Toxicology Letters. ISSN 0378-4274. 180 s S97- doi: 10.1016/j.toxlet.2008.06.400.
M. C. Samuelsen, J A. Olsen, Jørn A. Holme, A. Bergmann, E T M. Meussen-Elholm, Jørgen Stenersen, J.K. Hongslo, (1999). Estrogen-like properties of bisphenol A and brominated bisphenol A analogs in MCF-7 cells.
Solfrid Hegstad, Elsa Lundanes, Jørn A. Holme, Jan Alexander, (1999). Characterization of metabolites of benz[j]aceanthrylene in feces, urine and bile from rats by electrospray/atmospheric pressure chemical ionization mass spectrometry.

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