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MoBa Genetics

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MoBa Genetics is a research infrastructure aiming to genotype all participants in the Norwegian Mother, Father and Child Cohort Study (MoBa), and offer access to this data using a secure analysis platform to approved research projects.

MoBa Genetics is a research infrastructure aiming to genotype all participants in the Norwegian Mother, Father and Child Cohort Study (MoBa), and offer access to this data using a secure analysis platform to approved research projects.


Genotyping of MoBa

As of October 2019 data from 98 000 participants is available in MoBa Genetics. Any project who has access to MoBa Genetics will have access to, at any given time point, all quality-controlled genetic data in the infrastructure.

The genotyping of the MoBa samples is a collaborative effort, performed mainly in three research projects (see below) and several smaller projects. 

HARVEST - Per Minor Magnus, NIPH and Pål Njølstad, UiB (Principal investigators)

  • 33 000 samples (11 000 trios)
  • Analysed on Illumina HumanCoreExome at Genomics Core Facility Trondheim  

ERC (HARVEST) - Pål Njølstad, UiB (Principal investigator)

  • 27 000 samples (9 000 trios)
  • Analysed on Illumina Global Screening Array at ERASMUS MC 

NORMENT - Ole Andreassen, UiO/OUS (Principal investigator)

  • >100 000 samples (>30 000 trios)
  • Analysed on Illumina OmniExpress at deCODE (in progress) 

The principal investigators mentioned above (Per Minor Magnus, Pål Njølstad and Ole Andreassen) are, until 2025, to be invited to participate in any study using this genetic data and must be accredited in acknowledgements. This does not mean automatic co-authorship. MoBa expect all researchers to follow the guidelines from the Vancouver Convention regarding authorship. The number of collaborators and authorships should be agreed upon following a dialogue between the project participants. 

QC

An important part of the data delivery is assuring high quality data and quality control (QC) is performed on available data. This dataset consist of the following:

  • Raw data directly from the scanner (.idat)
  • Raw data exported from GenomeStudio
  • Quality controlled data
  • Additional documentation regarding the samples and data set (metadata)

More information about the dataset, what files are available and how the quality control was performed is available upon request or when accessing the infrastructure.

Cost for access to MoBa Genetics

The cost for access to MoBa Genetics is calculated based on the costs of the infrastructure and storing of the data, facilitating access to structure and quality controlled data as well as development and management of the infrastructure. The price is subject to change when MoBa Genetics is complete and a permanent infrastructure and administration model is in place.

When planning a new research project based on MoBa, please include costs related to data access and biological material in the project budget.

Price list for MoBa

Prices in this list may be changed at short notice. The current price will be the one set out in the contract between MoBa and the sub-study, or as stipulated in a decision letter. Included in the price is access to, at any given time point, the maximum number of quality-controlled genetic data. 

MoBa expect the project group to comprise the necessary competence to analyse the data.

The application prosess

Information on the application prosess may be found on the website:

Access to MoBa Genetics will only be given through the Services for sensitive data (TSD) at the University of Oslo (UiO). The principal investigator must esta establish a TSD project area at UiO. 

The TSD area information form must be attached to the application or sendt to mobaadm@fhi.no and should contain the following information:  

  • Name (PXXX) of TSD area
  • Expiration data for TSD area
  • Name and email address of TSD area administrator

The invoices will be sent as soon as data has been made available. The principal investigator will in most cases receive one invoice for genetic data and one for other data. 

Linkage to the Norwegian Prescription Database

The Norwegian Prescription Database is in pseudonymised form. This means that any linkage between the database and MoBa Genetics will entail large additional costs for the project. As internal resources have been reallocated due to corona handling, such a connection will not be possible until 2021 at the earliest due to a lack of personnel who can perform the work required.

Contact information

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