Mapping the available summarised evidence about exposure to intense sweeteners and potential relationships to appetite regulation and body weight development
The aim is to determine the extent and type of available summarised evidence regarding exposure to intense sweeteners and potential relationships to regulation of appetite and weight development.
There is an ongoing debate whether intense sweeteners have adverse effects on metabolic outcomes. Despite that consumption of intense sweeteners do not contribute to the total energy intake, it is hypothesized that they may increase the risk of obesity development through effects on metabolism. This is a protocol for a scoping review of reviews. The aim of to determine the extent and type of available summarised evidence regarding exposure to intense sweeteners and potential relationships to regulation of appetite and weight development. We will identify the intense sweeteners studied, study designs and experimental models used, and the comparisons, exposure levels, endpoints and hypotheses presented. Published reviews can provide a broad overview of topics, hypotheses and research approaches currently considered. Arksey and O’Malley’s framework with suggested enhancements will guide the scoping review process. This scoping review will consider any type of reviews of the literature. We will search the electronic databases Medline/PubMed, Embase, Cochrane Library, Epistemonikos, Web of Science and sources of grey literature for reviews published the last 10 years. Two reviewers will independently screen the literature. We will extract and chart data about the characteristics, scope and range of research presented in the included reviews.