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CeFH Genetics Friday: Haakon Egdetveit Nustad "Using neighboring correlation to identify differentially methylated regions"

Presentation by: Haakon Egdetveit Nustad, Oslo University Hospital

About Genetics Fridays

Genetics Fridays are held every Friday at the Centre of Fertility and Health. This is an informal venue for all employees at the Norwegian Institute of Public Health and collaborators who are working with genetics, planning to implement genetics in their work, or merely have an interest in genetics. There is room for presentations and/or discussions, where participants can share knowledge and experience, come up with ideas and discuss projects and methods. The big meeting room at the centre (room 201) is reserved every Friday from 13.00-14.00, available for meetings or discussions. Some Fridays there will be presentations on selected topics, methods or projects. These presentations will be announced in our event calendar. We make waffles for everyone at 12.30!

Contact Kristine Løkås Jacobsen if you have ideas on interesting topics we can address, or if you want to present something yourself.

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16. Nov 2018 - 13:00-14:00 | Seminar
Marcus Thranes gate 2, meeting room 2nd floor

About the speaker

Haakon E. Nustad is a PhD student at Oslo University Hospital in the Department of Medical Genetics. He works with DNA methylation analysis and statistics, and is especially interested in correlation structures in DNA methylation data. 

"Using neighboring correlation to identify differentially methylated regions"

It is well known that DNA methylation at sites close to each other tend to have similar methylation status. This gives rise to correlated DNA methylation measurements on an aggregated level, which can be approximated by calculating the neighboring correlation (auto-correlation lag 1). Here, we present a method for identifying differentially methylated regions between two groups of samples by comparing the neighboring correlation of the mean differences between the groups. By investigating how the correlation estimate change for increasing sample size, we are able to identify if there are differences between the groups within the region.