Hopp til innhold


CeFH lunch seminar: Can assisted reproduction be safer? Mouse models and human trials.

Presentation by Marisa Bartolomei, University of Pennsylvania Perelman School of Medicine

Presentation by Marisa Bartolomei, University of Pennsylvania Perelman School of Medicine

30. Aug | 2019

Marcus Thranes gate 2, meeting room 201, 2nd floor

About the speaker

Marisa Bartolomei is the Perelman Professor of Cell & Developmental Biology and co-Director of the Epigenetics Institute at the University of Pennsylvania Perelman School of Medicine. She received her BS from the University of Maryland and then obtained her PhD from the Johns Hopkins University School of Medicine. She trained as a postdoctoral fellow with Dr. Shirley Tilghman at Princeton University. In 1993, Dr. Bartolomei was appointed as an Assistant Professor at the University of Pennsylvania and was promoted to Associate Professor with tenure in 1999 and Professor in 2006. She was also an Investigator in the Howard Hughes Medical Institute. In 2006, Dr. Bartolomei received the Society for Women's Health Research Medtronics Prize for Contributions to Women's Health. In 2011, Dr. Bartolomei received the Jane Glick Graduate School Teaching Award for the University of Pennsylvania School of Medicine and a MERIT award from the NIH. She was elected as a Fellow of the American Association for the Advancement of Science in 2014 and was elected Member-At-Large of the Section on Biological Sciences for AAAS (2016-2020 term).  Dr. Bartolomei is the recipient of the 2017 Genetics Society Medal from the UK Genetics Society. Dr. Bartolomei’s research addresses the epigenetic mechanisms of genomic imprinting and X inactivation, as well as the impact of adverse environmental insults on epigenetic gene regulation using the mouse as a model.

About the presentation

Assisted Reproductive Technologies (ART), including in vitro fertilization (IVF), have enabled the birth of over 8 million babies worldwide. Although ART has produced many healthy children, over 80% of ART cycles do not result in a live birth. Moreover, studies of human singleton pregnancies demonstrate that ART is associated with abnormal placentation, small- and large-for-gestational age babies, preterm birth, miscarriage, perinatal mortality, preeclampsia, pregnancy complications, and congenital disorder. Although the patients’ underlying infertility/subfertility can contribute to these risks, numerous studies using fertile animal models suggest that ART procedures alone can induce abnormal placental development and small- and large-for-gestational age offspring. Our group is investigating how individual procedures used in ART can contribute to pregnancy using the mouse as a model. Moreover, we have initiated a parallel human trial to investigate the effects of frozen embryo transfer and preimplantation genetic testing.