The Norwegian VRE study
Project
|Updated
This study aims to learn more about the spread of antimicrobial resistance in enterococci, identify new targets for antimicrobial treatment and containment of infections caused by multidrug resistant (MDR) enterococci.
Summary
The aims of this study are to gain new insights in to the spread of antimicrobial resistance in enterococci, identify new targets for antimicrobial treatment and containment of infections caused by multidrug resistant (MDR) enterococci, and define novel infection control interventions for vancomycin resistant enterococci (VRE). This will be done by analysing and comparing clinical data and Whole genomes of VRE from Norway between January 2010 and July 2015 as well as genomes from invasive non-VRE and gut commensal Enterococcus faecium isolates from a population sample. The study will take advantage of an on-going national epidemiological study of VRE in Norway and will use collections of non-VRE isolates from the Norsk Overvåkningssystem for antibiotika Resistens hos Mikrober (NORM) registry and from a general population sample (Tromsø 7). By analysing genomes and presence of virulence and resistance determinants in these different strain collections we can identify determinants best suited for anti-virulence targeting of E. faecium,
reveal unknown transmission patterns and de novo generation of VRE as well as relate the Norwegian epidemiology to the global epidemiology of VRE.
Project leader
Jørgen Vildershøj Bjørnholt, Norwegian Institute of Public Health
Project participants
Kristin Hegstad, Vert-mikrobe interaksjoner, forskningsgruppe, UiT The Arctic University of Norway
Jørgen Vildershøj Bjørnholt, Infection Control and Preparedness, Norwegian Institute of Public Health
Start
30.07.2015
End
24.12.2023
Status
Active
Approvals
Regional committees for medical and health research ethics
Project owner/ Project manager
Norwegian Institute of Public Health