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  • Targeting of individuals for treatment of latent tuberculosis infection – a registerbased prospective cohort study

Project

Targeting of individuals for treatment of latent tuberculosis infection – a registerbased prospective cohort study - project description

Published Updated

The objective of this study is to explore the prevalence of risk factors among persons screened for LTBI or who have been notified to MSIS (TB register), and assess the impact of these factors in a Norwegian context.


Summary

Targeted testing and treatment of latent tuberculosis infection (LTBI) are important components of the World Health Organization’s (WHO’s) End TB strategy in low-incidence countries. The risk of developing TB after infection differs between individuals. To avoid treatment of a high number of infected persons to prevent one TB case, and to reduce the risk of severe adverse effects, treatment of LTBI is targeted primarily to individuals at highest risk of progression to TB. The use of preventive treatment for LTBI has increased in Norway. However, we have limited knowledge about medical risk factors, whether treatment is targeted to those at highest risk and to what extent this has an impact on the incidence of TB . The objective of this study is to explore the prevalence of risk factors among persons screened for LTBI or who have been notified to MSIS (TB register), and assess the impact of these factors in a Norwegian context.

The study includes blood-test results from eight Norwegian laboratories linked with data from Statistics Norway (SSB), the Norwegian Surveillance System for Infectious Diseases (MSIS), The Patient Registry (NPR) and the Norwegian Prescription Database (NorPD).

See the full project description at Cristin for more information about results, researchers, contact information etc.

Project participants

Project leader

Brita Askeland Winje, Norwegian Institute of Public Health

Project participants

Einar Heldal, Norwegian Institute of Public Health
Anne Torunn Mengshoel, Norwegian Institute of Public Health
Fredrik Oftung, Norwegian Institute of Public Health
Trude Margrete Arnesen, Norwegian Institute of Public Health
Richard Aubrey White, Norwegian Institute of Public Health

Start

01.07.2014

End

01.07.2021

Status

Active

Approvals

Regional committees for medical and health research ethics

Project owner/ Project manager

Norwegian Institute of Public Health

Project manager

Brita Askeland Winje