Hopp til innhold

Get alerts of updates about «DNA methylation in newborns compared to in utero exposures and health outcomes in children»

How often would you like to receive alerts from fhi.no? (This affects all your alerts)
Do you also want alerts about:

The email address you register will only be used to send you these alerts. You can cancel your alerts and delete your email address at any time by following the link in the alerts you receive.
Read more about the privacy policy for fhi.no

You have subscribed to alerts about:

  • DNA methylation in newborns compared to in utero exposures and health outcomes in children

Project

DNA methylation in newborns compared to in utero exposures and health outcomes in children - project description

Published Updated

We have formed a consortium (Pregnancy and Childhood Epigenetics or PACE) together with other birth and child cohorts that have also measured methylation.


Summary

Recent studies suggest that exposures in pregnancy may affect the health and disease of offspring either at birth, in childhood or later.

Abstract:

Recent studies suggest that exposures in pregnancy may affect the health and disease of offspring either at birth, in childhood or later. Epigenetics is a mechanism that can transfer the effects of fetal life to later health. Epigenetics refers to modifications of DNA that do not alter the DNA sequence. Methylation is the best studied epigenetic modification. From 2011-2013, National Institute of Environmental Health Science (NIEHS) has funded full-genome methylation measurements using the Illumina 450K platform in more than 1,700 MoBa umbilical vein samples. In collaboration with other cohorts, we have found that methylation in newborns reveals maternal exposures such as smoking, folate intake and prenatal air pollution. Because epigenome-wide analyses require large samples, we have formed a consortium (Pregnancy and Childhood Epigenetics or PACE) together with other birth and child cohorts that have also measured methylation.

See the full project description at Cristin for more information about results, researchers, contact information etc.

Project participants

Project leader

Per Magnus, Norwegian Institute of Public Health

Project participants

Per Magnus, Senter for fruktbarhet og helse, Norwegian Institute of Public Health
Tianyuan Wang, National Institute of Environmental Health Sciences
Shanshan Zhao, National Institute of Environmental Health Sciences
Christine Louise Parr, Norwegian Institute of Public Health
Maria Christine Magnus, Senter for fruktbarhet og helse, Norwegian Institute of Public Health
Christian Page, Senter for fruktbarhet og helse, Norwegian Institute of Public Health
Quaker Harmon, National Institute of Environmental Health Sciences
Sinjini Sikdar, National Institute of Environmental Health Sciences
Mi Kyeong Lee, National Institute of Environmental Health Sciences
Jianping Jin, Westat
Sarah Reese, National Institutes of Health
Wenche Nystad, Avdeling for kroniske sykdommer og aldring, Norwegian Institute of Public Health
Siri Eldevik Håberg, Senter for fruktbarhet og helse, Norwegian Institute of Public Health
Anita Haugan, Avdeling for helseundersøkelser, Norwegian Institute of Public Health

Start

29.08.2017

End

30.08.2022

Status

Active

Approvals

Regional committees for medical and health research ethics

Project owner/ Project manager

Norwegian Institute of Public Health

Responsible department

Centre for Fertility and Health