Analysis of miRNA and DNA methylation stautus in ADHD triads
Project
|Last update
This project will investigate whether epigenetic status at birth is important for neurodevelopmental disorders appearing in childhood and persisting into adulthood.
Summary
ADHD is a serious neurological disorder affecting 5-6 % of children in
Norway and is a major global health concern which seems to increase
in magnitude. There are indications of genetic as well as
environmental factors contributing to the development of the disorder,
and epigenetic changes have been suggested to be involved.
The main aim of this project is to investigate whether the
epigenetic status at birth is important for neurodevelopmental
disorders appearing in childhood and persisting into adulthood.
A specific aim is to identify early diagnostic biomarkers of ADHD.
The biomarkers will be important for early identification and
intervention of affected individuals, and may contribute to a
better mechanistic understanding of ADHD.
Using molecular methods, the project will characterize
epigenetic markers associated with ADHD. The biological
samples to be analyzed are cord blood samples already
collected and stored in the MoBa biobank. A triad case-control
study within MoBa will be designed, and data will be linked with
the Norwegian Patient Registry (NPR). A clinically validated
ADHD diagnosis in NPR will define the case group. Controls
matched by age and gender, negative for ADHD family history
and ADHD symptoms, will be randomly drawn from the MoBa
cohort. MiRNA and DNA methylation, as markers of epigenetic
status, will be characterized for cases and controls. Analysis of
the biological relevance of epigenetic changes for ADHD will be
performed.
Project leader
Nur Duale, Norwegian Institute of Public Health
Project participants
Nur Duale, Infection Control, Norwegian Institute of Public Health
Lene Brattsti Dypås, Infection Control, Norwegian Institute of Public Health
Gun Peggy Strømstad Knudsen, Health Data and Digitalisation, Norwegian Institute of Public Health
Ted Reichborn-Kjennerud, Mental Disorders, Norwegian Institute of Public Health
About the project
Start
01.08.2014
End
31.07.2027
Status
Active
Approvals
Regional committees for medical and health research ethics
Project owner/ Project manager
Norwegian Institute of Public Health