The importance of DNA methylation as a risk factor for developing testicular cancer
Prosjekt
|Sist endret
The incidence of testicular cancer in the Western world has tripled in recent decades, probably due to an interaction between environmental factors and vulnerability genes for testicular cancer.
Sammendrag
Epigenetic changes in the form of aberrant DNA methylation, caused by external factors, are thought to be involved in aetiology. Our hypothesis is that changes in DNA methylation at or near proven vulnerability genes for testicular cancer may be an important mechanism for modifying the risk. The aim of the study is to investigate the significance of DNA methylation in the development of testicular cancer. Changes in DNA methylation should be examined in serum samples from testicular cancer patients before diagnosis and compared with healthy controls. Our most interesting results (‘top hits’) will be replicated in a Dutch cohort of testicular cancer cases and controls. The results will increase our understanding of the epigenetic changes in the form of aberrant DNA methylation, which underlie the development of testicular cancer.
Prosjektleder
Marcin Wlodzimierz Wojewodzic, The Cancer Registry of Norway, Norwegian Institute of Public Health
Prosjektdeltakere
Trine Ballestad Rounge, Department of Pharmacy, University of Oslo
Tom Grotmol, The Cancer Registry of Norway, Norwegian Institute of Public Health
Jourik A. Gietema, University Medical Center Groningen
Om prosjektet
Start
01.01.2018
Slutt
31.05.2023
Status
Avsluttet
Prosjekteier/ prosjektansvarlig
Norwegian Institute of Public Health