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Prosjekt

Reliability of Free and Total BPA analyte measures in MoBa - prosjektbeskrivelse

Publisert

We propose a reliability study of BPA biomarkers over the course of pregnancy that separates total and free BPA, using the reliability substudy urine samples collected in MoBa.

  • Start

    01.08.2011

  • Slutt

    31.12.2014

  • Status

    Avsluttet

  • Godkjenninger

    Regional committees for medical and health research ethics

  • Prosjekteier/ prosjektansvarlig

    Norwegian Institute of Public Health

  • Tilknyttet studie

    Den norske mor, far og barn-undersøkelsen

  • Prosjektleder

    Heidi Aase

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Sammendrag

BBPA is rapidly metabolized. Therefore in the absence of a constant exposure source and intensity, biomarker levels would be expected to change over time, as has previously been reported. Only free (unconjugated) BPA exhibits endocrine activity*** however, in general, existing epidemiological studies have measured total BPA (the sum of free and conjugated) biomarkers. Total BPA biomarker concentration may further be impacted by contamination with environmental sources of free BPA, or in the biospecimen collection process or materials. We propose a reliability study of BPA biomarkers over the course of pregnancy that separates total and free BPA, using the reliability substudy urine samples collected in MoBa.
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Prosjektdeltakere

Prosjektleder

Heidi Aase, Norwegian Institute of Public Health