Here we present summary statistics from exemplar family-based genome-wide association analyses conducted in the Norwegian Mother, Father and Child Cohort Study (MoBa). These analyses use the MoBa trio data to illustrate how genotyped family cohorts can inform studies of health and functioning.

Genome-wide association analyses were conducted for four offspring phenotypes measured in childhood: height at age 7 years, sleep duration at age 7 years, depressive symptoms at age 8 years, and educational achievement at age 10 years. Height was reported by mothers in centimetres in the 7-year questionnaire. Sleep duration was mother-reported in the 7-year questionnaire using the item “Approximately how many hours does the child usually sleep on a weeknight?”, with response categories ranging from “8 hours or less” to “12 hours or more”. Depressive symptoms were assessed using the 13-item Short Mood and Feelings Questionnaire (SMFQ), reported by mothers in the 8-year questionnaire. Educational achievement at age 10 years was derived from Statistics Norway Educational Registry data as a composite of grade-five national test scores in numeracy, reading, and English, standardised within test year and subject before deriving the composite. All four phenotypes were standardised for the trio GWAS analyses to place them on a common scale and facilitate comparison of effect estimates.

For each phenotype, we provide summary statistics from two models. The first is a population-based GWAS among offspring with trio data. The second is a trio-based GWAS estimating the association between offspring genotype and phenotype conditional on maternal and paternal genotypes. Sample sizes were 41,761 for educational achievement, 23,786 for height, 24,376 for sleep duration, and 18,701 for depressive symptoms. Analyses were adjusted for offspring age, sex, genotyping batch, and the first 20 genetic principal components.

1. Population-based GWAS summary statistics
Tab delimited files (in the format of model06_trios_<phenotype>_mqc.basic) with one row per SNP and including the following columns: 
- SNP (in the format of chr:pos in hg19/GRCh37 genome build)
- Chromosome
- Basepair (base-pair position, GRCh37 genome build)
- A1/A2 (effect allele/other allele) 
- Wald_Stat (Wald statistic/Z-score)
- Wald_P (p-value for the association)
- Effect (effect estimate)
- SD (standard error of the effect)
- A1_Mean (effect allele mean)
- MAF (minor allele frequency)
- INFO_release4 (imputation quality score)

2. Trio-GWAS summary statistics 
Tab delimited files (in the format of model06_trios_<phenotype>_mqc.trios) with one row per SNP and including the following columns: 
- SNP (in the format of chr:pos in hg19/GRCh37 genome build)
- Chromosome, Basepair (base-pair position, GRCh37 genome build)
- A1/A2 (effect allele/other allele)
- Offspring_Effect (offspring direct effect estimate)
- Offspring_SD (standard error of the offspring direct effect)
- Offspring_Z (Wald statistic/Z-score of the offspring direct effect)
- Offspring_P (p-value for the offspring association)
- Father_Effect (paternal indirect effect estimate)
- Father_SD (standard error of the paternal indirect effect)
- Father_Z (Wald statistic/Z-score of paternal indirect effect)
- Father_P (p-value for the paternal association)
- Mother_Effect (maternal indirect effect estimate)
- Mother_SD (standard error of maternal indirect effect)
- Mother_Z (Wald statistic/Z-score of maternal indirect effect)
- Mother_P (p-value for the maternal association)
- MAF (minor allele frequency)
- INFO_release4 (imputation quality score)

The available summary statistics files are:
- Population-based GWAS of educational achievement: 
  model06_trios_exam_norm_mqc.basic.gz (sha-256: bb247ccf6138ed695d2ea555da2e3c2d148b4547d81968df1feabe396a0ec830)
- Trio GWAS of educational achievement: 
  model06_trios_exam_norm_mqc.trios.gz (sha-256: 18e2f69dc65b705262760b040004ab0de472416a7d01033d5b8e83165f282bb6)
- Population-based GWAS of height: 
  model06_trios_height_mqc.basic.gz (sha-256: 45137e1f4f0a87af4a642872767fa4607425664607e817e7cd3038a209d7fdad)
- Trio GWAS of height: 
  model06_trios_height_mqc.trios.gz (sha-256: d84a8d73d39c96e846657d2dc565e87237382f4dc200a5dcb65b924bdf262b1c)
- Population-based GWAS of sleep duration: 
  model06_trios_sleep_hrs_mqc.basic.gz (sha-256: 513c81e9a97daf2857d264f4ef6d3d34305c7fa5e372b3d6db9fb34332fa0691)
- Trio GWAS of sleep duration: 
  model06_trios_sleep_hrs_mqc.trios.gz (sha-256: 084ed305d9d598fd907fdcc0f66df48ebb2fe9a06513b8ab52a4426bd8500a68)
- Population-based GWAS of depressive symptoms:
  model06_trios_smfq_dep_mqc.basic.gz (sha-256: 44e5eb3c8414297f1883c041f80d0797cb861920df700b4ffcfdbaf04703e001) 
- Trio GWAS of depressive symptoms:
  model06_trios_smfq_dep_mqc.trios.gz (sha-256: f87b74759fbb3e05b6cc2e1921c35b9417ccf0b7d556a0d8119d8f4121b133bb)
NB: sha-256 checksums are provided for each summary file to support file integrity verification after download.